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Diseases","highestDevelopmentStatusNew":"Preclinical","highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","productSubType":"","amount2New":0,"dosageForm":"Oral","sponsorNew":"Proteostasis Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Proteostas.."},{"orgOrder":0,"company":"Proteostasis Therapeutics","sponsor":"Yumanity Therapeutics","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Yumanity Therapeutics and Proteostasis Therapeutics Announce Merger Agreement","therapeuticArea":"Neurology","highestDevelopmentStatus":"Phase I","country":"","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"August 2020","year":"2020","type":"Merger","leadProduct":"YTX-7739","moa":"SCD","url1":"","url2":"","graph1":"Neurology","graph2":"Phase I","graph3":"Proteostasis Therapeutics","amount2":0,"therapeuticAreaNew":"Neurology","highestDevelopmentStatusNew":"Phase I","highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"Proteostasis Therapeutics \/ Proteostasis Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Proteostas.."},{"orgOrder":0,"company":"Proteostasis Therapeutics","sponsor":"Yumanity Therapeutics","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Yumanity Therapeutics Completes Reverse Merger with Proteostasis Therapeutics","therapeuticArea":"Neurology","highestDevelopmentStatus":"Phase I","country":"","productType":"Small molecule","productStatus":"New Molecular Entity","date":"December 2020","year":"2020","type":"Merger","leadProduct":"YTX-7739","moa":"SCD","url1":"","url2":"","graph1":"Neurology","graph2":"Phase I","graph3":"Proteostasis Therapeutics","amount2":0,"therapeuticAreaNew":"Neurology","highestDevelopmentStatusNew":"Phase I","highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Proteostasis Therapeutics

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                          01

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : The combined company will operate under the name Yumanity Therapeutics. Yumanity’s lead product candidate is YTX-7739, which is currently in Phase 1 clinical development for the treatment and disease mo...

                          Product Name : YTX-7739

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 23, 2020

                          Lead Product(s) : YTX-7739

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Yumanity Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : The combined company will leverage their common scientific expertise in protein misfolding, and will work to advance Yumanity’s lead candidate YTX-7739, currently in Phase 1 clinical development for th...

                          Product Name : YTX-7739

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 24, 2020

                          Lead Product(s) : YTX-7739

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Recipient : Yumanity Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          03

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : In in vitro studies conducted at Calibr, the drug discovery division of Scripps Research, PTI-129 demonstrated the potential to reduce viral protein production in host cells by activating the adaptive bra...

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 01, 2020

                          Lead Product(s) : PTI-129

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : Dutch regulatory board supportive of choices program, which may lead toward market authorization for treatment of people with CF Choices protocol receives 'high strategic priority' score from CTN.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 13, 2020

                          Lead Product(s) : Dirocaftor,Posenacaftor,Nesolicaftor

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : The organoid system is a European Commission-funded global project that has attracted a selected number of drug developers and leading CF experts to create a blueprint for customized CF therapy.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 22, 2020

                          Lead Product(s) : Dirocaftor,Posenacaftor,Nesolicaftor

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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