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receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"The University of British Columbia","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"The University of British Columbia \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"The University of British Columbia \/ Inapplicable"},{"orgOrder":0,"company":"Praxis Precision Medicines","sponsor":"Cowen","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Public Offering","leadProduct":"PRAX-114","moa":"GABAA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Praxis Precision Medicines","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Praxis Precision Medicines \/ 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Molecule","year":"2023","type":"Inapplicable","leadProduct":"Ulotaront","moa":"TAA1 receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Sunovion Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Sunovion Pharmaceuticals \/ Otsuka America Pharmaceutical, Inc.","highestDevelopmentStatusID":"9","companyTruncated":"Sunovion Pharmaceuticals \/ Otsuka America Pharmaceutical, Inc."},{"orgOrder":0,"company":"Nobilis Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Xenon","moa":"||NMDA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Nobilis Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Inapplicable"},{"orgOrder":0,"company":"Aptinyx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"NYX-783","moa":"NMDA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Aptinyx","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Aptinyx \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Aptinyx \/ Inapplicable"},{"orgOrder":0,"company":"Aptinyx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"NYX-783","moa":"NMDA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Aptinyx","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Aptinyx \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Aptinyx \/ Inapplicable"},{"orgOrder":0,"company":"Aptinyx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"NYX-783","moa":"NMDA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Aptinyx","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Aptinyx \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Aptinyx \/ Inapplicable"},{"orgOrder":0,"company":"Aptinyx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"NYX-783","moa":"NMDA receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II\/ Phase III","graph3":"Aptinyx","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Aptinyx \/ Inapplicable","highestDevelopmentStatusID":"9","companyTruncated":"Aptinyx \/ Inapplicable"}]

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01

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : The collaborations aim to support NRx for the development of NRX-101 (D-cycloserine) in the treatment of bipolar depression with suicidality.

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : $10.0 million

November 02, 2024

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Alvogen

Deal Size : $345.0 million

Deal Type : Collaboration

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02

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : NRX-101 (D-cycloserine & Lurasidone HCl) is a fixed dose combination which is under clinical development for various indications including for the treatment of suicidal bipolar depression.

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 05, 2024

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : NRX-101 (D-cycloserine & Lurasidone HCl) is a fixed dose combination which is under clinical development for various indications including for the treatment of suicidal bipolar depression.

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 30, 2024

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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04

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : NRX-101, a combination of the NMDA antagonist D-cycloserine and lurasidone, is in phase 2/3 trials for treating resistant bipolar depression and suicidal ideation.

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 03, 2024

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

The University of British Columbia

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German Wound Congress
Not Confirmed

The University of British Columbia

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German Wound Congress
Not Confirmed

Details : ProZ-001 (cannabidiol) is a CB1 receptor negative allosteric modulator, which is approved for the treatment of patients with dravet syndrome and lennox-gastaut syndrome.

Product Name : ProZ-001

Product Type : Controlled Substance

Upfront Cash : Inapplicable

February 27, 2024

Lead Product(s) : Cannabidiol

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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06

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : NRX-101, a fixed-dose combination of D-cycloserine and lurasidone, is in phase 2/3 trials for treatment-resistant bipolar depression and suicidal ideation.

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 22, 2024

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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07

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : The collaboration aims to develop and commercialize NRX-101, an fixed dose oral combination of D-cycloserine and lurasidone for treatment-resistant suicidal bipolar depression (S-TRBD). It is one of the first oral antidepressants targeting the NMDA recep...

Product Name : NRX-101

Product Type : Other Small Molecule

Upfront Cash : $10.0 million

July 06, 2023

Lead Product(s) : Cycloserine,Lurasidone Hydrochloride

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Lotus Pharmaceutical Industries

Deal Size : $345.0 million

Deal Type : Collaboration

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08

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : SEP-363856 (ulotaront) is a TAAR1 agonist with 5-HT1A agonist activity, is currently under investigation for the treatment of schizophrenia, generalized anxiety disorder and the adjunctive treatment of MDD with additional indications under consideration.

Product Name : SEP-363856

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 26, 2023

Lead Product(s) : Ulotaront

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Otsuka America Pharmaceutical, Inc.

Deal Size : Inapplicable

Deal Type : Inapplicable

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09

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : The funding will be used to complete the CESTO II clinical study designed to evaluate the efficacy and safety of its NFL-101 (tobacco leaf protein) treatment as a smoking cessation therapy.

Product Name : NFL-101

Product Type : Plant Extract/Herbal

Upfront Cash : Undisclosed

February 20, 2023

Lead Product(s) : Tobacco Leaf Extract

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : Bpifrance

Deal Size : $1.8 million

Deal Type : Funding

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10

German Wound Congress
Not Confirmed
German Wound Congress
Not Confirmed

Details : Under the terms of the collaboration, NFL-Biosciences will use the CEA's molecular imaging resources to better understand the mechanism of action of NFL 101. NFL-101, is a standardized, nicotine free tobacco leaf extract protected by two patent families.

Product Name : NFL-101

Product Type : Plant Extract/Herbal

Upfront Cash : Undisclosed

February 02, 2023

Lead Product(s) : Tobacco Leaf Extract

Therapeutic Area : Psychiatry/Psychology

Highest Development Status : Phase II/ Phase III

Sponsor : CEA

Deal Size : Undisclosed

Deal Type : Collaboration

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