Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Brolucizumab
Therapeutic Area : Ophthalmology
Study Phase : Approved
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $8.0 million
Deal Type : Agreement
Pyxis Oncology Obtains $8 Million Payment for the Sale of Royalty Rights
Details : Under the agreement, Vector will distribute Pepaxti (melphalan flufenamide), indicated in combination with dexamethasone, in the MENA region for the treatment of patients with multiple myeloma.
Brand Name : Beovu
Molecule Type : Large molecule
Upfront Cash : $8.0 million
March 27, 2024
Lead Product(s) : Brolucizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Approved
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $8.0 million
Deal Type : Agreement
Pyxis Oncology Announces $50 Million Private Placement
Details : Net proceeds will support clinical development of the antibody-drug conjugate candidate PYX-201, currently in trials for relapsed/refractory solid tumors.
Brand Name : PYX-201
Molecule Type : Large molecule
Upfront Cash : Undisclosed
February 27, 2024
Lead Product(s) : Sotigalimab
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Apexigen
Deal Size : $10.7 million
Deal Type : Acquisition
Pyxis Oncology Successfully Completes Acquisition of Apexigen
Details : Through the acquisition, Pyxis Oncology positions at forefront of Antibody-Drug Conjugate (ADC) development by adding PYX-107 (sotigalimab), a potential best-in-class Phase 2 CD40 agonist in clinical development for liposarcoma, melanoma, and other cance...
Brand Name : PYX-107
Molecule Type : Large molecule
Upfront Cash : Undisclosed
August 23, 2023
Lead Product(s) : Sotigalimab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Apexigen
Deal Size : $10.7 million
Deal Type : Acquisition
Pyxis Oncology Advances PYX-106 and PYX-201 Clinical Programs
Details : PYX-106 is a fully human immunotherapy antibody candidate in development that blocks the activity of Siglec-15, it is an emerging immune suppressor expressed across a broad range of solid tumors.
Brand Name : PYX-106
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 30, 2023
Lead Product(s) : Sotigalimab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Pyxis Oncology
Deal Size : $16.0 million
Deal Type : Acquisition
Pyxis Oncology to Acquire Apexigen
Details : Through the acquisition, Pyxis Oncology positions at forefront of Antibody-Drug Conjugate (ADC) development by adding APX 005 (sotigalimab), a potential best-in-class Phase 2 CD40 agonist in clinical development for liposarcoma, melanoma, and other cance...
Brand Name : APX 005
Molecule Type : Large molecule
Upfront Cash : Undisclosed
May 24, 2023
Lead Product(s) : Sotigalimab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Pyxis Oncology
Deal Size : $16.0 million
Deal Type : Acquisition
Lead Product(s) : Sotigalimab,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Brookline Capital Markets
Deal Size : $2.8 million
Deal Type : Private Placement
Apexigen Announces Approximately $2.8 Million Private Placement Financing
Details : The gross proceeds will be used to finance and further support the company’s ongoing Phase 2 clinical study evaluating its CD40 antibody, APX005M (sotigalimab), in combination with doxorubicin in patients with liposarcoma.
Brand Name : APX005M
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 24, 2023
Lead Product(s) : Sotigalimab,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Brookline Capital Markets
Deal Size : $2.8 million
Deal Type : Private Placement
Lead Product(s) : Sotigalimab,Paclitaxel,Carboplatin
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Sotiga (sotigalimab) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses leading tumor-specific i...
Brand Name : Sotiga
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 19, 2023
Lead Product(s) : Sotigalimab,Paclitaxel,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Sotigalimab,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : APX005M (sotigalimab) is a CD40 agonist that has been designed to reverse the systemic immune suppression that typically affects cancer patients, through the activation of several mechanisms of immune functionality.
Brand Name : APX005M
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 14, 2022
Lead Product(s) : Sotigalimab,Doxorubicin Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Sotigalimab,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The combination of intratumoral sotigalimab and systemic pembrolizumab was well-tolerated and demonstrated an improved clinical response rate relative to the standard of care, pembrolizumab monotherapy.
Brand Name : Sotiga
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 11, 2022
Lead Product(s) : Sotigalimab,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Sotigalimab,Paclitaxel,Carboplatin
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Sotiga (sotigalimab) in combination with neoadjuvant chemoradiation induced higher pathologic complete response rates, an important predictor of survival, in patients with both adenocarcinoma and squamous cell carcinoma.
Brand Name : Sotiga
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 10, 2022
Lead Product(s) : Sotigalimab,Paclitaxel,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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