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    [{"orgOrder":0,"company":"Q32 Bio","sponsor":"Atlas Venture","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"","productType":"Large molecule","year":"2020","type":"Series A Financing","leadProduct":"ADX-914","moa":"IL-7R","graph1":"Immunology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0.050000000000000003,"dosageForm":"","sponsorNew":"Q32 Bio \/ Atlas Venture","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ Atlas Venture"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"OrbiMed Advisors","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"","productType":"Large molecule","year":"2020","type":"Series B Financing","leadProduct":"ADX-914","moa":"IL-7R","graph1":"Immunology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0.059999999999999998,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0.059999999999999998,"dosageForm":"","sponsorNew":"Q32 Bio \/ OrbiMed Advisors","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ OrbiMed Advisors"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2021","type":"Not Applicable","leadProduct":"ADX-097","moa":"","graph1":"Nephrology","graph2":"Preclinical","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"","sponsorNew":"Q32 Bio \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Q32 Bio \/ Not Applicable"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2021","type":"Not Applicable","leadProduct":"ADX-097","moa":"","graph1":"Nephrology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Q32 Bio \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ Not Applicable"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ADX-097","moa":"Complement activity","graph1":"Dermatology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"","sponsorNew":"Q32 Bio \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ Not Applicable"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ADX-097","moa":"Complement activity","graph1":"Nephrology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"","sponsorNew":"Q32 Bio \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ Not Applicable"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Horizon Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"ADX-914","moa":"IL-7 alpha receptor","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"","sponsorNew":"Q32 Bio \/ Horizon Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ Horizon Therapeutics"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Horizon Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Collaboration","leadProduct":"ADX-914","moa":"IL-7 alpha receptor","graph1":"Immunology","graph2":"Phase I","graph3":"Q32 Bio","amount2":0.69999999999999996,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0.69999999999999996,"dosageForm":"Injectable\/Injection","sponsorNew":"Q32 Bio \/ Horizon Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Q32 Bio \/ Horizon Therapeutics"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Horizon Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Bempikibart","moa":"","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Q32 Bio \/ Horizon Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ Horizon Therapeutics"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Homology Medicines","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2023","type":"Merger","leadProduct":"Bempikibart","moa":"","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"","sponsorNew":"Q32 Bio \/ Q32 Bio","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ Q32 Bio"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"OrbiMed","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2023","type":"Private Placement","leadProduct":"Bempikibart","moa":"","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0.040000000000000001,"dosageForm":"","sponsorNew":"Q32 Bio \/ OrbiMed","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ OrbiMed"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Homology Medicines","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2024","type":"Merger","leadProduct":"Bempikibart","moa":"","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Q32 Bio \/ Q32 Bio","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ Q32 Bio"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"OrbiMed","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2024","type":"Private Placement","leadProduct":"Bempikibart","moa":"","graph1":"Dermatology","graph2":"Phase II","graph3":"Q32 Bio","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0.040000000000000001,"dosageForm":"Injection","sponsorNew":"Q32 Bio \/ OrbiMed","highestDevelopmentStatusID":"8","companyTruncated":"Q32 Bio \/ OrbiMed"},{"orgOrder":0,"company":"Q32 Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Bempikibart","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Q32 Bio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Q32 Bio \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"Q32 Bio \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Q32 Bio

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                            01

                            Q32 Bio

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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Q32 Bio Completes Enrollment in Phase 2 Trial of Bempikibart for Atopic Dermatitis

                            Details : ADX-914 (bempikibart), is a fully human anti-IL-7Rα antibody, being developed in a Phase 2 trial for the treatment of atopic dermatitis (AD).

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 09, 2024

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : Homology Medicines

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Q32 Bio Closes Merger with Homology Medicines and Raises $42 Million

                            Details : The combined company will develop Q32 Bio’s clinical candidates, ADX-914 for atopic dermatitis and alopecia areata, and ADX-097 for complement disorders, both in Phase 2.

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 25, 2024

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : Homology Medicines

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            03

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : OrbiMed

                            Deal Size : $42.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Q32 Bio Closes Merger with Homology Medicines and Raises $42 Million

                            Details : Proceeds will advance the clinical development of Q32 Bio’s assets: ADX-914 (bempikibart) in Phase 2 for atopic dermatitis and ADX-097 in Phase 2 for complement disorders.

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 25, 2024

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : OrbiMed

                            Deal Size : $42.0 million

                            Deal Type : Private Placement

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                            04

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : Homology Medicines

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Q32 Bio and Homology Medicines Announce Merger Agreement

                            Details : The combined company will advance the development of Q32 Bio’s two clinical development candidates, ADX-914 (bempikibart) in Phase 2 for the treatment of atopic dermatitis (AD) and alopecia areata (AA), and ADX-097 entering Phase 2 for the treatment of...

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            November 16, 2023

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : Homology Medicines

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            05

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : OrbiMed

                            Deal Size : $42.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Q32 Bio and Homology Medicines Announce Merger Agreement

                            Details : The proceeds will be used to advance the clinical development of Q32 Bio’s two wholly owned assets, ADX-914 (bempikibart), in Phase 2 for the treatment of atopic dermatitis (AD) and alopecia areata (AA), and ADX-097 entering Phase 2 for the treatment o...

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            November 16, 2023

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : OrbiMed

                            Deal Size : $42.0 million

                            Deal Type : Private Placement

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                            06

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Horizon Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Q32 Bio and Horizon Therapeutics plc Announce Dosing of First Patient in Phase 2 Trial of Bempikibart (formerl...

                            Details : ADX-914 (bempikibart) is a fully human anti-IL-7R alpha antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and TSLP, which is investigated for the treatment of severe alopecia areata.

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 13, 2023

                            Lead Product(s) : Bempikibart

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Horizon Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : ADX-914

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Horizon Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Q32 Bio and Horizon Therapeutics plc Announce Dosing of First Patient in Phase 2 Trial of ADX-914 for Atopic D...

                            Details : ADX-914 is a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and TSLP in patients suffering from moderate to severe atopic dermatitis.

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 27, 2022

                            Lead Product(s) : ADX-914

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Horizon Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : ADX-914

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Horizon Therapeutics

                            Deal Size : $700.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Q32 Bio and Horizon Therapeutics Announce Collaboration in Autoimmune Diseases

                            Details : Under the terms of the agreement, Horizon will fund development through completion of the two Phase 2 trials of ADX-914, with Q32 being operationally responsible for the conduct of all program-related activities.

                            Brand Name : ADX-914

                            Molecule Type : Large molecule

                            Upfront Cash : $55.0 million

                            August 15, 2022

                            Lead Product(s) : ADX-914

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Horizon Therapeutics

                            Deal Size : $700.0 million

                            Deal Type : Collaboration

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                            09

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : ADX-097

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Q32 Bio Presents New Preclinical Data at the International Society of Nephrology Frontiers Meeting Demonstrati...

                            Details : Data for ADX-097, a bi-functional fusion protein comprising a humanized anti-C3d monoclonal antibody showed that C3d-mediated tissue targeting of factor H results in potent, durable and efficacious local complement blockade without systemic complement in...

                            Brand Name : ADX-097

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 23, 2022

                            Lead Product(s) : ADX-097

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Q32 Bio

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                            Medlab Asia & Asia Health
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                            Q32 Bio

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                            Lead Product(s) : ADX-097

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Q32 Bio Initiates First-in-Human Phase 1 Clinical Study of ADX-097 for the Treatment of Complement Disorders

                            Details : In preclinical studies, ADX-097 demonstrated the potential to potently inhibit disease-causing complement activation in the tissue while avoiding systemic complement inhibition.

                            Brand Name : ADX-097

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 26, 2022

                            Lead Product(s) : ADX-097

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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