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    [{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Trilaciclib","moa":"CDK4\/CDK6","graph1":"Oncology","graph2":"Phase II","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Quantum Leap Healthcare \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Quantum Leap Healthcare \/ Not Applicable"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Aerpio Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"","productType":"Small molecule","year":"2020","type":"Collaboration","leadProduct":"Razuprotafib","moa":"PTP","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Quantum Leap 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Healthcare"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Omeros","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"Narsoplimab","moa":"MASP-2","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Quantum Leap Healthcare \/ Omeros","highestDevelopmentStatusID":"10","companyTruncated":"Quantum Leap Healthcare \/ Omeros"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Athenex","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Paclitaxel","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Quantum Leap Healthcare \/ Athenex","highestDevelopmentStatusID":"8","companyTruncated":"Quantum Leap Healthcare \/ Athenex"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"ALX Oncology","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Evorpacept","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Quantum Leap Healthcare \/ Quantum Leap Healthcare","highestDevelopmentStatusID":"6","companyTruncated":"Quantum Leap Healthcare \/ Quantum Leap Healthcare"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Atossa Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"(Z)-endoxifen","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Quantum Leap Healthcare \/ Quantum Leap Healthcare","highestDevelopmentStatusID":"8","companyTruncated":"Quantum Leap Healthcare \/ Quantum Leap Healthcare"},{"orgOrder":0,"company":"Quantum Leap Healthcare","sponsor":"Atossa Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Z-endoxifen","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Quantum Leap Healthcare","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Quantum Leap Healthcare \/ Quantum Leap Healthcare","highestDevelopmentStatusID":"8","companyTruncated":"Quantum Leap Healthcare \/ Quantum Leap Healthcare"}]

    Find Clinical Drug Pipeline Developments & Deals by Quantum Leap Healthcare

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                            01

                            Quantum Leap Healthcare

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                            Lead Product(s) : Endoxifen

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Atossa Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Atossa Therapeutics and Quantum Leap Healthcare Provide Enrollment Update for (Z)-Endoxifen Arm of Ongoing I-S...

                            Details : Endoxifen (z-endoxifen) is the most active metabolite of the FDA approved selective estrogen receptor modulator (SERM), tamoxifen. It has demonstrated that the anti-estrogenic effects and is being evaluated for ER+/HER2+ breast cancer.

                            Brand Name : Endoxifen

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 28, 2023

                            Lead Product(s) : Endoxifen

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Atossa Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Quantum Leap Healthcare

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                            Lead Product(s) : Endoxifen

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Atossa Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Atossa Therapeutics and Quantum Leap Healthcare Announce New Study Arm to Evaluate (Z)-Endoxifen in the Ongoin...

                            Details : (Z)-endoxifen is the most active metabolite of the FDA approved selective estrogen receptor modulator (SERM), tamoxifen. It has demonstrated that the anti-estrogenic effects and is being evaluated for ER+/HER2+ breast cancer.

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 21, 2023

                            Lead Product(s) : Endoxifen

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Atossa Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Quantum Leap Healthcare

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                            Lead Product(s) : Evorpacept,Fam-trastuzumab Deruxtecan-nxki

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : ALX Oncology

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ALX Oncology and Quantum Leap Healthcare Collaborative™ Announce First Patient Dosed in the I-SPY-P1 TRIAL i...

                            Details : ALX148 (evorpacept), is a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is being investigated in combination with enhertu for breast cancer.

                            Brand Name : ALX148

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 13, 2023

                            Lead Product(s) : Evorpacept,Fam-trastuzumab Deruxtecan-nxki

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : ALX Oncology

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Quantum Leap Healthcare

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                            Lead Product(s) : Paclitaxel,Encequidar,Dostarlimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Athenex

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Athenex Announces Quantum Leap Healthcare Collaborative Reports Positive Trial Result of I-SPY2 Trial for Oral...

                            Details : Oral paclitaxel, relative to intravenous paclitaxel, was associated with less neuropathy and was not associated with an increase in febrile neutropenia.

                            Brand Name : Taxol

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 20, 2022

                            Lead Product(s) : Paclitaxel,Encequidar,Dostarlimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Athenex

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Quantum Leap Healthcare

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                            Lead Product(s) : Narsoplimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Recipient : Omeros

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Omeros Corporation Reports Narsoplimab Treatment Results in Critically Ill COVID-19 Patients in I-SPY COVID Tr...

                            Details : OMS721 (narsoplimab) was not observed to shorten the time to recovery in critically ill patients with COVID-19 in this study. The study did not identify any new safety signals for narsoplimab in the setting of critically ill COVID-19 patients.

                            Brand Name : OMS721

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 15, 2022

                            Lead Product(s) : Narsoplimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Recipient : Omeros

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Narsoplimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Omeros

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            I-SPY COVID Trial Sponsored by Quantum Leap Healthcare Collaborative Reports Assessment of Narsoplimab for Tre...

                            Details : OMS721 (narsoplimab) was selected for inclusion in the I-SPY COVID Trial because of its demonstrated ability to inhibit complement activation, inflammation, and coagulation, the three components that characterize COVID-19.

                            Brand Name : OMS721

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 15, 2022

                            Lead Product(s) : Narsoplimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Omeros

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Quantum Leap Healthcare

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                            Lead Product(s) : Evorpacept,Deruxtecan

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : ALX Oncology

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ALX Oncology and Quantum Leap Healthcare Collaborative™ Announce the Selection of Evorpacept in the I-SPY-P1...

                            Details : The lead product candidate, evorpacept (ALX148), is a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain.

                            Brand Name : ALX148

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 15, 2022

                            Lead Product(s) : Evorpacept,Deruxtecan

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : ALX Oncology

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Quantum Leap Healthcare

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                            Lead Product(s) : Cyclosporine,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Quantum Leap Healthcare Collaborative Announces Termination of the Cyclosporine Treatment Arm for Critically I...

                            Details : To minimize potential toxicity a relatively low oral dose of 5 mg/kg/day for a duration of 5 days was selected to be administered to patients randomized into the CSA (cyclosporine) arm.

                            Brand Name : CsA

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            August 08, 2022

                            Lead Product(s) : Cyclosporine,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Quantum Leap Healthcare

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                            Lead Product(s) : ARX788

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Ambrx Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ambrx Biopharma Inc. and Quantum Leap Healthcare Collaborative™ Announce the Inclusion of ARX788 in the I-SP...

                            Details : ARX788 is an anti-HER2 antibody drug conjugate (ADC), is a homogeneous and highly stable ADC that maximizes potential anti-tumor activity by optimizing the number and position of its payloads and the chemical bonds that conjugate the payloads to the anti...

                            Brand Name : ARX788

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 25, 2022

                            Lead Product(s) : ARX788

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Ambrx Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Aviptadil Acetate,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : NRx Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            I-SPY COVID Trial Sponsored by Quantum Leap Healthcare Collaborative Suggests No Clinical Benefit with Additio...

                            Details : Aviptadil is a synthetic form of Human Vasoactive Intestinal Polypeptide and was selected because of the potential to reduce inflammation and stabilize the air sacs of hospitalized because of injury from acute respiratory distress syndrome, which is the ...

                            Brand Name : Zyesami

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            March 31, 2022

                            Lead Product(s) : Aviptadil Acetate,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : NRx Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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