Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Undisclosed
Deal Type : Collaboration
Ensysce Advances Overdose Protection Platform in Clinical Development
Details : The collaboration aims to examine and evaluate the full commercial dose range of the PF614-MPAR drug product, the combination of PF614 with the trypsin inhibitor nafamostat, to treat chronic pain.
Brand Name : PF614-MPAR
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 20, 2024
Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Diethylamide
Therapeutic Area : Neurology
Study Phase : Phase I
Recipient : South Rampart Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
South Rampart Completes Phase 1 Study and Expands Phase 2 Plans
Details : SRP 3D (diethylamide) is a first-in-class non-opioid analgesic activating pain signaling pathways in the midbrain's periaqueductal grey. It’s in phase 1 trials for acute pain.
Brand Name : SRP 3D
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 02, 2024
Lead Product(s) : Diethylamide
Therapeutic Area : Neurology
Highest Development Status : Phase I
Recipient : South Rampart Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : YCT529
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
UK Launches First Trial of Hormone-Free Male Birth Control Pill
Details : YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor that prevents sperm production by blocking access to vitamin A. It is under phase 1 clinical development for male contraception.
Brand Name : YCT-529
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 20, 2023
Lead Product(s) : YCT529
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : YCT529
Therapeutic Area : Endocrinology
Study Phase : Phase I
Recipient : YourChoice Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : YCT-529 is a retinoic acid receptor-alpha (RAR-alpha) inhibitor that prevents sperm production by blocking access to vitamin A. It is under phase 1 clinical development for male contraception.
Brand Name : YCT-529
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 13, 2023
Lead Product(s) : YCT529
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Recipient : YourChoice Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Fostroxacitabine Bralpamide,Lenvatinib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Recipient : Medivir
Deal Size : Not Applicable
Deal Type : Not Applicable
Quotient Sciences Supports Medivir with Updated Formulation of Fostrox
Details : MIV-818 (fostroxacitabine bralpamide) is DNA inhibitor. It is being evaluated under phase 1/2 clinical development in combination with Lenvima (lenvatinib) for the treatment of hepatocellular carcinoma.
Brand Name : MIV-818
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 27, 2023
Lead Product(s) : Fostroxacitabine Bralpamide,Lenvatinib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Recipient : Medivir
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : HSDB 4295,Carbidopa
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Recipient : Evecxia Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : EVX-101 is a novel, proprietary, gastro-retentive, sustained-release tablet formulation of 5-hydroxytryptophan (5-HTP), which is investigated for the treatment of major depressive disorder.
Brand Name : EVX-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 21, 2023
Lead Product(s) : HSDB 4295,Carbidopa
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Recipient : Evecxia Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CRN04894
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : Crinetics Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Details : Under the partnership, Quotient will support Crinetics' CRN04894 pediatric program. The partnership will utilize Quotient Sciences' unique Translational Pharmaceutics® platform to provide integrated formulation development, clinical manufacturing, and t...
Brand Name : CRN04894
Molecule Type : Small molecule
Upfront Cash : Undisclosed
March 30, 2023
Lead Product(s) : CRN04894
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : Crinetics Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Not Applicable
Deal Type : Not Applicable
Ensysce Biosciences' PF614-MPAR Enters Final Stage of Phase 1 Study
Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...
Brand Name : PF614-MPAR
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 25, 2023
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Ensysce Biosciences
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Berberine Ursodeoxycholate
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : HighTide Therapeutics
Deal Size : Undisclosed
Deal Type : Agreement
Details : HTD1801 (berberine ursodeoxycholate), is a first-in-class new molecular entity, currently in Phase II trials for the treatment of primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH).
Brand Name : HTD1801
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 15, 2022
Lead Product(s) : Berberine Ursodeoxycholate
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : HighTide Therapeutics
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Buprenorphine
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Emplicure
Deal Size : Undisclosed
Deal Type : Partnership
Details : Under the partnership, Quotient Sciences will support the GMP manufacture and first clinical pharmacokinetic (PK) study for EMPLI03 (buprenorphine) using its unique Translational Pharmaceutics® platform for the treatment of moderate to severe pain.
Brand Name : Empli03
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 29, 2022
Lead Product(s) : Buprenorphine
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Emplicure
Deal Size : Undisclosed
Deal Type : Partnership