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    [{"orgOrder":0,"company":"QurAlis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"QRL-201","moa":"STMN2","graph1":"Neurology","graph2":"Phase I","graph3":"QurAlis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"QurAlis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"QurAlis \/ Inapplicable"},{"orgOrder":0,"company":"QurAlis","sponsor":"EQT Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Series B Financing","leadProduct":"QRL-201","moa":"STMN2","graph1":"Neurology","graph2":"Phase I","graph3":"QurAlis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"QurAlis \/ EQT Life Sciences","highestDevelopmentStatusID":"6","companyTruncated":"QurAlis \/ EQT Life Sciences"},{"orgOrder":0,"company":"QurAlis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"QRL-201","moa":"STMN2","graph1":"Neurology","graph2":"Phase I","graph3":"QurAlis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"QurAlis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"QurAlis \/ Inapplicable"},{"orgOrder":0,"company":"QurAlis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"QRL-201","moa":"STMN2","graph1":"Neurology","graph2":"Phase 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Inapplicable"},{"orgOrder":0,"company":"QurAlis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"QRA-244","moa":"Kv7.2\/Kv7.3","graph1":"Neurology","graph2":"Preclinical","graph3":"QurAlis","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"QurAlis \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"QurAlis \/ Inapplicable"},{"orgOrder":0,"company":"QurAlis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"QRL-101","moa":"Kv7.2\/Kv7.3","graph1":"Neurology","graph2":"Phase I","graph3":"QurAlis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"QurAlis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"QurAlis \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by QurAlis

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                            01

                            QurAlis

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                            Lead Product(s) : QRL-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis Reports QRL-101 Phase 1 Data on ALS & Epilepsy Biomarkers in Volunteers

                            Details : QRL-101 is a potentially best-in-class selective Kv7.2/7.3 ion channel opener for the treatment of hyperexcitability-induced disease progression in ALS

                            Product Name : QRL-101

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 12, 2025

                            Lead Product(s) : QRL-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

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                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis Progresses QRL-201 ALS Trial with First Dosed in Dose Range-Finding Phase

                            Details : QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in Amyotrophic lateral sclerosis patients.

                            Product Name : QRL-201

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            November 19, 2024

                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

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                            Lead Product(s) : QRL-204

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $622.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            QurAlis Grants Lilly Exclusive Global License For QRL-204 In ALS, FTD

                            Details : QurAlis granted Lilly an exclusive, worldwide license to develop and commercialize QRL-204, a potentially best-in-class splice-switching ASO and other UNC13A-targeting compounds.

                            Product Name : QRL-204

                            Product Type : Other Large Molecule

                            Upfront Cash : $45.0 million

                            March 06, 2024

                            Lead Product(s) : QRL-204

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $622.0 million

                            Deal Type : Licensing Agreement

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                            04

                            QurAlis

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                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : EQT Life Sciences

                            Deal Size : $88.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            QurAlis Closes $88 Million Series B Financing to Advance Precision Medicines for Neurodegenerative Diseases

                            Details : The proceeds from the financing will fund clinical development of QRL-201 and QRL-101, QurAlis's lead product candidates in ALS. QRL-201 is a first-in-class therapeutic product candidate aiming to restore STMN2 expression in ALS patients.

                            Product Name : QRL-201

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            September 03, 2023

                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : EQT Life Sciences

                            Deal Size : $88.0 million

                            Deal Type : Series B Financing

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                            05

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                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis Receives Clinical Trial Authorisation (CTA) in European Union (EU) for QRL-201, a First-in-Class STATH...

                            Details : QRL-201 is a first-in-class precision therapeutic product candidate aiming to restore STATHMIN-2 (STMN2) expression in ALS patients. ANQUR is the first-ever study to evaluate a therapy that rescues STMN2 expression in ALS patients.

                            Product Name : QRL-201

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            June 06, 2023

                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

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                            Lead Product(s) : QRL-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis Announces First-in-Human Dose in Phase 1 Clinical Trial of QRL-101, a First-in-Class Kv7 Precision The...

                            Details : QRL-101 a first-in-class selective Kv7.2/7.3 ion channel opener for the treatment of ALS that aims to reduce hyperexcitability-induced neurodegeneration. Drug dosing in Phase 1 clinical trial has been initiated.

                            Product Name : QRL-101

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 01, 2023

                            Lead Product(s) : QRL-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

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                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis Presents Data About STATHMIN-2 Role in Neuronal Disease Biology and TDP-43 Biomarker Identification at...

                            Details : QRL-201 is a first-in-class molecule that rescues STATHMIN-2, a well-known protein important for neural repair and axonal stability, the expression of which is significantly decreased in the majority of ALS patients.

                            Product Name : QRL-201

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 15, 2022

                            Lead Product(s) : QRL-201

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

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                            Lead Product(s) : QRA-244

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cell Reports Publishes Discovery Data Supporting the Importance of Ion Channel, Kv7.2/7.3 as a Therapeutic Tar...

                            Details : QRL-101 (QRA-244) is QurAlis’ lead drug candidate intended to treat motor neuron hyperexcitability-induced disease progression in ALS patients, which is estimated to be up to 50% of all ALS cases.

                            Product Name : QRA-244

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 06, 2021

                            Lead Product(s) : QRA-244

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            QurAlis

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                            Lead Product(s) : QRA-244

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            QurAlis' QRA-244 Demonstrates up to 20-Fold Increase in Potency and Reduction in Side Effects Compared to Reti...

                            Details : The poster presentation showed that QRA-244 has comparable effects to retigabine (ezogabine) at up to 20-fold lower concentration in motor neurons differentiated from patient-derived iPSCs as measured by an all-optical electrophysiology experiment.

                            Product Name : QRA-244

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 12, 2020

                            Lead Product(s) : QRA-244

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Polaris Partners

                            Deal Size : $42.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            QurAlis Nabs $42M Funding Round for ALS, Frontotemporal Dementia

                            Details : QurAlis intends to use this funding to support the development of new therapies for ALS and genetically related frontotemporal dementia (FTD), neurodegenerative diseases for which there is currently no cure.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            May 13, 2020

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Polaris Partners

                            Deal Size : $42.0 million

                            Deal Type : Series A Financing

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