Lead Product(s) : Radiprodil
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
GRIN Initiates Astroscape Trial of Radiprodil For Tuberous Sclerosis Complex
Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for the treatment of Tuberous Sclerosis Complex and Focal Cortical Dysplasia Type II.
Brand Name : RGH-896
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 08, 2024
Lead Product(s) : Radiprodil
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Radiprodil
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
GRIN Therapeutics Reports Positive Data from Honeycomb Trial of Radiprodil
Details : RGH-896 (radiprodil) is an investigational, selective and potent negative allosteric modulator of the N-methyl-D-aspartate receptor subtype 2B (NR2B or GluN2B).
Brand Name : RGH-896
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 09, 2024
Lead Product(s) : Radiprodil
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Radiprodil
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Radiprodil is a selective NAM of the Nmethyl-D-aspartate receptor subtype 2B. It inhibits NMDA glutamate currents when tested using receptors containing NR2B subunits coded by GoF mutations in the GRIN2B and GRIN2A genes, which are known to cause GRIN-re...
Brand Name : UCB3491
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 23, 2023
Lead Product(s) : Radiprodil
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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