Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TRK-950,Ramucirumab,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Toray Industries
Deal Size : Undisclosed
Deal Type : Collaboration
Bolt Biotherapeutics Updates Cancer Immunotherapy Co-Development with Toray
Details : The collaboration aims to develop TRK-950, an Caprin-1 designed to target multiple solid tumor types. Currently, it is being evaluated for the treatment of gastric cancer.
Product Name : TRK-950
Product Type : Antibody
Upfront Cash : Undisclosed
February 11, 2025
Lead Product(s) : TRK-950,Ramucirumab,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Toray Industries
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
ALX Presents Updated Data from ASPEN-06 Phase 2 Trial in HER2-Positive Gastric Cancer
Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.
Product Name : ALX148
Product Type : Protein
Upfront Cash : Inapplicable
January 23, 2025
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ALX Reports Phase 2 Data Showing Evorpacept Improves HER2-Positive Gastric Cancer Response
Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Not Applicable
July 31, 2024
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : $63.2 million
Deal Type : Public Offering
Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Undisclosed
October 10, 2023
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : $63.2 million
Deal Type : Public Offering
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : $55.0 million
Deal Type : Public Offering
ALX Oncology Announces Pricing of Public Offering
Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Undisclosed
October 05, 2023
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : $55.0 million
Deal Type : Public Offering
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : Undisclosed
Deal Type : Public Offering
ALX Oncology Announces Proposed Public Offering
Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Undisclosed
October 04, 2023
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Piper Sandler
Deal Size : Undisclosed
Deal Type : Public Offering
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Not Applicable
October 03, 2023
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in patients with gastric cancer and gastroesophageal junction adenocarcinoma.
Product Name : ALX148
Product Type : Large molecule
Upfront Cash : Not Applicable
June 26, 2023
Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Ramucirumab
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CYRAMZA (ramucirumab), an antiangiogenic therapy and VEGF Receptor 2 antagonist, demonstrated and was well-tolerated in Chinese patients and overall patient population, safety and efficacy profile in Chinese population was consistent with global studies.
Product Name : Cyramza
Product Type : Large molecule
Upfront Cash : Not Applicable
October 10, 2022
Lead Product(s) : Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Ramucirumab
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Innovent Biologics
Deal Size : $45.0 million
Deal Type : Partnership
Innovent and Lilly Expand Strategic Partnership in Oncology
Details : Under the terms of the agreement, upon regulatory approvals of Cyramza® in the hepatocellular carcinoma indication and Retsevmo® in the non-small lung cancer indication, and then intends to commercialize Cyramza® and Retsevmo® in China.
Product Name : Cyramza
Product Type : Large molecule
Upfront Cash : Undisclosed
March 28, 2022
Lead Product(s) : Ramucirumab
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Innovent Biologics
Deal Size : $45.0 million
Deal Type : Partnership