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Hoffmann-La Roche \/ Not Applicable"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"INDIA","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Ranibizumab","moa":"","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"","sponsorNew":"Lupin Ltd \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Lupin Ltd \/ Not Applicable"},{"orgOrder":0,"company":"Polpharma Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"Ranibizumab","moa":"","graph1":"Ophthalmology","graph2":"Approved","graph3":"Polpharma Biologics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"","sponsorNew":"Polpharma Biologics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Polpharma Biologics \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals for Ranibizumab

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Study Phase : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : Ranivisio (ranibizumab) is a VEGF-A inhibitor, which is indicated for the treatment of patients with neovascular (wet) age-related macular degeneration, macular edema following retinal vein occlusion, and diabetic macular edema.

                          Brand Name : Ranivisio

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 11, 2023

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Midas Pharma

                          02

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Study Phase : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : The active substance of Ranivisio is ranibizumab, a monoclonal antibody fragment (ATC code: S01LA04) which modulates angiogenesis by inhibiting vascular endothelial growth factor A. Ranivisio is a biosimilar medicinal product.

                          Brand Name : Ranivisio

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 23, 2022

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Midas Pharma

                          03

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : LUBT010 (ranibizumab) is a VEGF-A inhibitor, which is being evaluated for the treatment of patients with neovascular (wet) age-related macular degeneration, macular edema & diabetic macular edema.

                          Brand Name : LUBT010

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 06, 2024

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : Susvimo (ranibizumab) is a VEGF-A inhibitor, intravitreal implant which is being investigated for the treatment of patients with neovascular diabetic macular edema.

                          Brand Name : Susvimo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 18, 2024

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : Through acquisition, Sandoz will access US biosimilar Cimerli (ranibizumab) from Coherus, used for treating Neovascular (Wet) Age-Related Macular Degeneration and Diabetic Macular Edema.

                          Brand Name : Cimerli

                          Molecule Type : Large molecule

                          Upfront Cash : $170.0 million

                          March 04, 2024

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Sandoz B2B

                          Deal Size : $170.0 million

                          Deal Type : Divestment

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                          06

                          Eyconis

                          Country arrow
                          Medizin 2025
                          Not Confirmed

                          Eyconis

                          Country arrow
                          Medizin 2025
                          Not Confirmed

                          Details : The newly formed Eyconis has exclusive rights to develop and commercialize TransCon RBZ (ranibizumab) ophthalmology products globally, which are used for wet age-related macular degeneration (AMD).

                          Brand Name : TransCon RBZ

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 29, 2024

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : Ascendis Pharma

                          Deal Size : $248.0 million

                          Deal Type : Licensing Agreement

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                          07

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : Through acquisition, Sandoz will access US biosimilar Cimerli (ranibizumab) from Coherus, used for treating Neovascular (Wet) Age-Related Macular Degeneration and Diabetic Macular Edema.

                          Brand Name : Cimerli

                          Molecule Type : Large molecule

                          Upfront Cash : $170.0 million

                          January 22, 2024

                          Lead Product(s) : Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Sandoz B2B

                          Deal Size : $170.0 million

                          Deal Type : Divestment

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                          08

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : The funding aims to support the OPT-302 (sozinibercept) in combination with ranibizumab, which is the first-in-class VEGF-C/D ‘trap’ in clinical development for Wet age-related macular degeneration.

                          Brand Name : OPT-302

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          December 27, 2023

                          Lead Product(s) : Sozinibercept,Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Carlyle Group

                          Deal Size : $170.0 million

                          Deal Type : Financing

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                          09

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : The company intends to use the net proceeds for advancing the Phase 3 clinical trials ShORe and COAST for OPT-302 (sozinibercept), a novel inhibitor of vascular endothelial growth factor (VEGF)-C and VEGF-D, for the treatment of wet AMD.

                          Brand Name : OPT-302

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 28, 2023

                          Lead Product(s) : Sozinibercept,Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $57.6 million

                          Deal Type : Financing

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                          10

                          Medizin 2025
                          Not Confirmed
                          Medizin 2025
                          Not Confirmed

                          Details : OPT-302 (sozinibercept) is a novel recombinant trap fusion protein targeting inhibition of vascular endothelial growth factors C and D (VEGF-C and VEGF-C), two ligand mediators of angiogenesis and vascular leakage involved in retinal vascular diseases.

                          Brand Name : OPT-302

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 26, 2023

                          Lead Product(s) : Sozinibercept,Ranibizumab

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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