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    [{"orgOrder":0,"company":"Rapt Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Zelnecirnon","moa":"CXCR-4 receptor","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Rapt Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Rapt Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Rapt Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Rapt Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Tivumecirnon","moa":"||CCR4","graph1":"Oncology","graph2":"Phase II","graph3":"Rapt 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    Find Clinical Drug Pipeline Developments & Deals by Rapt Therapeutics

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                            01

                            Rapt Therapeutics

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                            Rapt Therapeutics

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                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : The Column Group

                            Deal Size : $150.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces $150 Million Private Placement

                            Details : The net proceeds from the private placement will support the research and development of the company’s pipeline, including FLX475 (tivumecirnon) in combination with Keytruda for treating NSCLC.

                            Product Name : FLX475

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            December 23, 2024

                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : The Column Group

                            Deal Size : $150.0 million

                            Deal Type : Private Placement

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                            02

                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Stops Zelnecirnon Program After Clinical Hold

                            Details : RPT193 (zelnecirnon) is an antagonist of CCR4 receptor that inhibits CCR4-mediated chemotaxis toward both CCL22 and CCL17. It was being evaluated for the treatment of atopic dermatitis.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 11, 2024

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
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                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Announces Phase 2 Trial Result of Tivumecirnon with Anti-PD-1 in Head and Neck Cancer

                            Details : FLX475 (tivumecirnon) is a small molecule CCR4 antagonist, is being evaluated with Pembrolizumab for the treatment of advanced head and neck squamous cell carcinoma.

                            Product Name : FLX475

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 04, 2024

                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Clinical Hold on Studies Evaluating Zelnecirnon

                            Details : RPT193 (zelnecirnon) is an antagonist of CCR4 receptor that inhibits CCR4-mediated chemotaxis toward both CCL22 and CCL17. It is being evaluated for the treatment of atopic dermatitis.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 20, 2024

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Rapt Therapeutics

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                            Cophex
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                            Rapt Therapeutics

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                            Cophex
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Initiation of Phase 2a Trial of RPT193 in Patients with Moderate-to-Severe Asthma

                            Details : RPT193 is a small molecule, CCR4 antagonist designed to selectively inhibit the migration of Th2 cells into inflamed tissues In allergic inflammatory diseases such as atopic dermatitis and asthma.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 29, 2023

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            Rapt Therapeutics

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                            MAGHREB PHARMA
                            Not Confirmed
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                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Positive Data, Including Objective Response Rates and Progression-Free Survival, f...

                            Details : FLX475 (tivumecirnon), an oral small molecule CCR4 antagonist designed to block the migration of regulatory T cells, in combination with the checkpoint inhibitor pembrolizumab for pateint with NSCLC.

                            Product Name : FLX475

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 11, 2023

                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            Rapt Therapeutics

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                            MAGHREB PHARMA
                            Not Confirmed
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $75.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Pricing of Public Offering of Common Stock

                            Details : RPT193 is an orally-administered small molecule CCR4 antagonist that blocks the recruitment of inflammatory immune cells, known as Th2 cells, which are clinically implicated in a broad range of inflammatory disorders.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            November 17, 2022

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $75.0 million

                            Deal Type : Public Offering

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                            08

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            Rapt Therapeutics

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                            MAGHREB PHARMA
                            Not Confirmed
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                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Presents Update from its Phase 1/2 Clinical Trial for FLX475 as Monotherapy and in Combinati...

                            Details : FLX475 is a small molecule CCR4 antagonist designed to block the migration of regulatory T cells (Treg) specifically into tumors, but not healthy tissues. Treg represent a dominant pathway for downregulating the immune response.

                            Product Name : FLX475

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 12, 2022

                            Lead Product(s) : Tivumecirnon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Rapt Therapeutics

                            U.S.A arrow
                            MAGHREB PHARMA
                            Not Confirmed

                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Initiation of Phase 2b Trial of RPT193 in Patients with Moderate-to-Severe Atopic ...

                            Details : In a post-hoc statistical analysis comparing RPT193-treated patients to placebo-treated patients, the improvements in EASI, EASI-50 and BSA at Day 43 were statistically significant. RPT193 was well tolerated in the Phase 1b study.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 23, 2022

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Rapt Therapeutics

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                            MAGHREB PHARMA
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                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RAPT Therapeutics Announces Biomarker Data from Phase 1b Trial of RPT193 Consistent with Disease Modification ...

                            Details : The biomarker data, showed patients treated with RPT193 experienced a statistically significant improvement (p<0.001) in the meta-analysis derived atopic dermatitis (MADAD) score, a well-established gene signature that tracks with disease severity.

                            Product Name : RPT193

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 28, 2022

                            Lead Product(s) : Zelnecirnon

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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