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                          Top Deals by Deal Size (USD bn)

                          01

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                          Details : Under the agreement, Catalent Pharma will be responsible for the production of Jotrol (resveratrol) softgel capsules to support Jupiter’s upcoming Phase 2a clinical trial in Parkinson’s disease.

                          Product Name : Jotrol

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 03, 2025

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Jupiter Neurosciences

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          02

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                          Details : The partnership aims to support all aspects of Jupiter’s upcoming Phase 2a clinical trial for Parkinson’s disease evaluating JOTROL, Jupiter’s patented resveratrol-based therapeutic platform.

                          Product Name : Jotrol

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 30, 2025

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Zina Biopharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          03

                          ELCC
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                          ELCC
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                          Details : The Company intends to use the proceeds to fund the Phase 2 trial of its product candidate Jotrol, an enhanced orally administered resveratrol formulation, in patients with Parkinson’s Disease

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 04, 2024

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Dominari Securities

                          Deal Size : $11.0 million

                          Deal Type : Public Offering

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                          04

                          ELCC
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                          ELCC
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                          Details : The Company intends to use the proceeds to fund the Phase 2 trial of its product candidate Jotrol, an enhanced orally administered resveratrol formulation, in patients with Parkinson’s Disease

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 02, 2024

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Dominari Securities

                          Deal Size : $11.0 million

                          Deal Type : Public Offering

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                          05

                          ELCC
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                          Details : Jupiter Neurosciences is developing JNS101 (resveratrol) is in Phase II trials for the treatment of Friedreich's Ataxia, a rare disease that causes damage to the nervous system, as well as mobility dysfunctions.

                          Product Name : Jotrol

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 02, 2022

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Spartan Capital Securities

                          Deal Size : $15.0 million

                          Deal Type : Public Offering

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                          06

                          ELCC
                          Not Confirmed
                          ELCC
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                          Details : The U.S. patent covers the suspension of active ingredient resveratrol and other compounds in a micellar emulsion that can be delivered via oral capsule.

                          Product Name : Jotrol

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 01, 2020

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          ELCC
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                          Details : The company's lead candidate, IMC-1, is a novel combination antiviral therapy designed to synergistically suppress Herpes Simplex Virus-1activation and replication, with the end goal of reducing viral mediated disease burden.

                          Product Name : Jotrol

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 22, 2020

                          Lead Product(s) : Resveratrol

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : National Institutes of Health

                          Deal Size : $1.7 million

                          Deal Type : Funding

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