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    [{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Clearside Biomedical","sponsor":"Regenxbio","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Clearside Biomedical","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Clearside Biomedical \/ REGENXBIO","highestDevelopmentStatusID":"8","companyTruncated":"Clearside Biomedical \/ REGENXBIO"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Regenxbio","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Collaboration","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":1.75,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":1.75,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Regenxbio \/ AbbVie","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ AbbVie"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Regenxbio","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Collaboration","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":1.75,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":1.75,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Regenxbio \/ AbbVie","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ AbbVie"},{"orgOrder":0,"company":"Regenxbio","sponsor":"AbbVie Inc","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Regenxbio \/ Abbvie","highestDevelopmentStatusID":"10","companyTruncated":"Regenxbio \/ Abbvie"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"RGX-314","moa":"VEGF A","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Not Applicable","leadProduct":"RGX-314","moa":"","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Regenxbio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Regenxbio \/ Not Applicable"},{"orgOrder":0,"company":"Regenxbio","sponsor":"AbbVie Inc","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"RGX-314","moa":"","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Regenxbio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Regenxbio \/ AbbVie Inc","highestDevelopmentStatusID":"10","companyTruncated":"Regenxbio \/ AbbVie Inc"},{"orgOrder":0,"company":"Regenxbio","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Public Offering","leadProduct":"RGX-314","moa":"","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Regenxbio","amount2":0.13,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0.13,"dosageForm":"Injection","sponsorNew":"Regenxbio \/ Morgan Stanley","highestDevelopmentStatusID":"10","companyTruncated":"Regenxbio \/ Morgan Stanley"}]

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    RGX-314

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                            01

                            Regenxbio

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                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Morgan Stanley

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            REGENXBIO Announces Proposed Public Offering of Common Stock

                            Details : ABBV-RGX-314 is a one-time treatment for wet AMD, using the NAV® AAV8 vector to deliver a gene encoding a monoclonal anti-VEGF antibody fragment.

                            Brand Name : ABBV-RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 06, 2024

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Morgan Stanley

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

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                            02

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            REGENXBIO Reports Interim Data from Phase II AAVIATE® Trial for Wet AMD

                            Details : ABBV-RGX-314, a NAV® AAV8 vector encoding an antibody fragment, is in phase 2 trials targeting the VEGF pathway for wet AMD.

                            Brand Name : ABBV-RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            January 16, 2024

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            REGENXBIO Presents Interim Data from Phase II Bridging Study Evaluating the Clinical Performance of RGX-314 Us...

                            Details : RGX-314 consists of the NAV® AAV8 vector, which encodes an antibody fragment designed to inhibit VEGF. It is believed to inhibit the VEGF pathway by which new, leaky blood vessels grow and contribute to the accumulation of fluid in the retina.

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 11, 2023

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            REGENXBIO Presents Positive Interim Data from and the Expansion of Phase II ALTITUDE® Trial of RGX-314 for th...

                            Details : RGX-314 consists of the NAV AAV8 vector, which encodes an antibody fragment designed to inhibit vascular endothelial growth factor (VEGF), is believed to inhibit the VEGF pathway by which new, leaky blood vessels grow and contribute to the accumulation o...

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 03, 2022

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : AbbVie Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            REGENXBIO Announces Enrollment Complete in Cohort 5 of Phase II AAVIATE® Trial

                            Details : RGX-314 consists of NAV® AAV8 vector, which encodes an antibody fragment designed to inhibit VEGF, is believed to inhibit the VEGF pathway by which new, leaky blood vessels grow and contribute to the accumulation of fluid in the retina.

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 08, 2022

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : AbbVie Inc

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : $1,750.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            REGENXBIO Announces Closing of Eye Care Collaboration Agreement with AbbVie

                            Details : AbbVie and REGENXBIO will collaborate and share costs on additional trials of RGX-314, including the planned second pivotal trial evaluating subretinal delivery for the treatment of wet AMD and future trials.

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : $370.0 million

                            November 09, 2021

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : $1,750.0 million

                            Deal Type : Collaboration

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                            07

                            Regenxbio

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                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Regenxbio Presents Positive Initial Data from Phase Ii Altitude™ Trial of RGX-314 for The Treatment of Diabe...

                            Details : RGX-314 was reported to be well tolerated in the 15 patients dosed with RGX-314 in Cohort 1. One serious adverse event was reported in one patient dosed with RGX-314, which occurred in the patient's untreated fellow eye and is considered not related to R...

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 09, 2021

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : $1,750.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            AbbVie and REGENXBIO Announce Eye Care Collaboration

                            Details : Under the collaboration, REGENXBIO will be responsible for completion of the ongoing trials of RGX-314. RGX-314 is believed to inhibit the VEGF pathway by which new, leaky blood vessels grow and contribute to the accumulation of fluid in the retina.

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : $370.0 million

                            September 13, 2021

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : $1,750.0 million

                            Deal Type : Collaboration

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                            09

                            Regenxbio

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                            Regenxbio

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Regenxbio Announces Presentations at the American Academy of Ophthalmology 2020 Annual Meeting

                            Details : Company will deliver two oral presentations will be presented at the American Academy Ophthalmology (AAO) 2020 Annual Meeting. The first presentation will feature data from the RGX-314 Phase I/II subretinal trial for the treatment of wet age-related macu...

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 10, 2020

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Clearside Biomedical

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                            CPhI India 2024
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                            Clearside Biomedical

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                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Regenxbio

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Clearside Biomedical’s Licensing Partner REGENXBIO Doses First Patient in its Phase 2 Gene Therapy Trial Usi...

                            Details : REGENXBIO has dosed the first patient in its Phase 2 clinical trial to evaluate the suprachoroidal delivery of RGX-314, an adeno-associated virus (AAV) gene therapy, using Clearside’s SCS Microinjector® for the treatment of wet age-related macular deg...

                            Brand Name : RGX-314

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 09, 2020

                            Lead Product(s) : RGX-314

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Regenxbio

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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