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    [{"orgOrder":0,"company":"Ocugen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"Autologous Cartilagenous Tissue","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Ocugen","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Ocugen \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Ocugen \/ Inapplicable"},{"orgOrder":0,"company":"3S Bio Inc","sponsor":"Selecta Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"CHINA","productType":"Enzyme","year":"2020","type":"Licensing Agreement","leadProduct":"Pegadricase","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"3S Bio Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"3S Bio Inc \/ Selecta Biosciences","highestDevelopmentStatusID":"10","companyTruncated":"3S Bio Inc \/ Selecta Biosciences"},{"orgOrder":0,"company":"Swedish Orphan Biovitrum AB","sponsor":"Selecta Biosciences","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"SWEDEN","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Pegadricase","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Swedish Orphan Biovitrum AB","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Swedish Orphan Biovitrum AB \/ Selecta Biosciences","highestDevelopmentStatusID":"10","companyTruncated":"Swedish Orphan Biovitrum AB \/ Selecta Biosciences"},{"orgOrder":0,"company":"Selecta Biosciences","sponsor":"Swedish Orphan Biovitrum AB","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Licensing Agreement","leadProduct":"Pegadricase","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Selecta Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB","highestDevelopmentStatusID":"10","companyTruncated":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB"},{"orgOrder":0,"company":"Selecta Biosciences","sponsor":"Swedish Orphan Biovitrum AB","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Licensing Agreement","leadProduct":"Pegadricase","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Selecta Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB","highestDevelopmentStatusID":"10","companyTruncated":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB"},{"orgOrder":0,"company":"Selecta Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Enzyme","year":"2023","type":"Inapplicable","leadProduct":"Pegadricase","moa":"||Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Selecta Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Selecta Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Selecta Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Selecta Biosciences","sponsor":"Swedish Orphan Biovitrum AB","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Enzyme","year":"2023","type":"Licensing Agreement","leadProduct":"Pegadricase","moa":"||Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Selecta Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB","highestDevelopmentStatusID":"10","companyTruncated":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB"},{"orgOrder":0,"company":"Selecta Biosciences","sponsor":"Swedish Orphan Biovitrum AB","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Enzyme","year":"2020","type":"Inapplicable","leadProduct":"Pegadricase","moa":"Undisclosed","graph1":"Rheumatology","graph2":"Phase III","graph3":"Selecta Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB","highestDevelopmentStatusID":"10","companyTruncated":"Selecta Biosciences \/ Swedish Orphan Biovitrum AB"},{"orgOrder":0,"company":"LG Chem","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"SOUTH KOREA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Tigulixostat","moa":"Xanthine oxidase","graph1":"Rheumatology","graph2":"Phase III","graph3":"LG Chem","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"LG Chem \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"LG Chem \/ Inapplicable"},{"orgOrder":0,"company":"LG Chem","sponsor":"Innovent Biologics","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"SOUTH KOREA","productType":"Other Small Molecule","year":"2022","type":"Collaboration","leadProduct":"Tigulixostat","moa":"Xanthine oxidase","graph1":"Rheumatology","graph2":"Phase III","graph3":"LG Chem","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"LG Chem \/ Innovent Biologics","highestDevelopmentStatusID":"10","companyTruncated":"LG Chem \/ Innovent Biologics"},{"orgOrder":0,"company":"Xortx Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Oxypurinol","moa":"Xanthine oxidase","graph1":"Rheumatology","graph2":"Phase III","graph3":"Xortx Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xortx Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Xortx Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Xortx Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rheumatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Oxypurinol","moa":"Xanthine oxidase","graph1":"Rheumatology","graph2":"Phase III","graph3":"Xortx Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xortx Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Xortx Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Fuji Yakuhin","sponsor":"Eisai","pharmaFlowCategory":"D","therapeuticArea":"Rheumatology","country":"JAPAN","productType":"Other Small Molecule","year":"2020","type":"Licensing Agreement","leadProduct":"Dotinurad","moa":"URAT1\u00a0","graph1":"Rheumatology","graph2":"Phase III","graph3":"Fuji Yakuhin","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Fuji Yakuhin \/ Eisai","highestDevelopmentStatusID":"10","companyTruncated":"Fuji Yakuhin \/ Eisai"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Xortx Therapeutics

                            U.S.A arrow
                            AACR Annual meeting
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                            Xortx Therapeutics

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                            Lead Product(s) : Oxypurinol

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XORTX Announces Update for Discussion with the FDA

                            Details : XRx-026 program is a proprietary formulation of oxypurinol, which is being developed to treat patients suffering from gout.

                            Product Name : XRx-026

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 19, 2025

                            Lead Product(s) : Oxypurinol

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Xortx Therapeutics

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                            AACR Annual meeting
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                            Xortx Therapeutics

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                            AACR Annual meeting
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                            Lead Product(s) : Oxypurinol

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            XORTX Commences Gout Program NDA Discussions with the FDA

                            Details : XRx-026 program is a proprietary formulation of oxypurinol, which is being developed to treat patients suffering from gout.

                            Product Name : XRx-026

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 24, 2025

                            Lead Product(s) : Oxypurinol

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Selecta Biosciences

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                            AACR Annual meeting
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                            Selecta Biosciences

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                            AACR Annual meeting
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                            Lead Product(s) : Pegadricase,ImmTOR

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : $705.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Selecta Announces Transition of Manufacturing and Clinical Operations of ImmTOR for SEL-212 to Commercializati...

                            Details : Sobi will transition the manufacturing and development rights of ImmTOR for SEL-212 to Sobi. SEL-212, a combination of Selecta’s ImmTOR immune tolerance platform and a therapeutic uricase enzyme (pegadricase), is in development for chronic refractory g...

                            Product Name : SEL-212

                            Product Type : Enzyme

                            Upfront Cash : $75.0 million

                            October 31, 2023

                            Lead Product(s) : Pegadricase,ImmTOR

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : $705.0 million

                            Deal Type : Licensing Agreement

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                            04

                            Selecta Biosciences

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                            AACR Annual meeting
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                            Selecta Biosciences

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                            AACR Annual meeting
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                            Lead Product(s) : Pegadricase,SEL-110

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase 3 DISSOLVE Program of SEL-212 in Chronic Refractory Gout Meets Primary Endpoint

                            Details : SEL-212 (combination of ImmTOR immune tolerance platform and pegadricase) is designed to reduce serum urate levels in people with chronic refractory gout, potentially reducing harmful tissue urate deposits which causes debilitating gout flares and joint ...

                            Product Name : SEL-212

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 21, 2023

                            Lead Product(s) : Pegadricase,SEL-110

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Ocugen

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                            AACR Annual meeting
                            Not Confirmed

                            Ocugen

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                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Autologous Cartilagenous Tissue

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ocugen Announces Phase 3 Confirmatory Clinical Trial Agreement for NeoCart®

                            Details : Ocugen’s proposed control and overall design for the Phase 3 study of NeoCart®, a regenerative cell therapy for the repair of full-thickness lesions of the knee cartilage in adults.

                            Product Name : NeoCart

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 16, 2022

                            Lead Product(s) : Autologous Cartilagenous Tissue

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            LG Chem

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                            AACR Annual meeting
                            Not Confirmed

                            LG Chem

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                            Lead Product(s) : Tigulixostat

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Innovent Biologics

                            Deal Size : $95.5 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Innovent and LG Chem Announce Strategic Collaboration for Tigulixostat, a Novel Non-Purine Xanthine Oxidase In...

                            Details : LC350189 (tigulixostat) is a novel xanthine oxidase inhibitor targeting the reduction of uric acid in purine metabolism, by inhibiting the activity of xanthine oxidase.

                            Product Name : LC350189

                            Product Type : Other Small Molecule

                            Upfront Cash : $10.0 million

                            December 14, 2022

                            Lead Product(s) : Tigulixostat

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Innovent Biologics

                            Deal Size : $95.5 million

                            Deal Type : Collaboration

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                            07

                            3S Bio Inc

                            China arrow
                            AACR Annual meeting
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                            3S Bio Inc

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                            AACR Annual meeting
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                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Selecta Biosciences

                            Deal Size : $4.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            3SBio Inc. Received Milestone Payment of USD 4 Million Upon Commencement of Phase III Clinical Program of SEL-...

                            Details : Selecta Biosciences, 3SBio partner, has commenced the phase III clinical program of a combination therapy involving SEL-212 for the treatment of chronic refractory gout on behalf of SobiTM, and has made a milestone payment of USD 4 million to 3SBio.

                            Product Name : SEL-212

                            Product Type : Enzyme

                            Upfront Cash : Undisclosed

                            November 23, 2020

                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Selecta Biosciences

                            Deal Size : $4.0 million

                            Deal Type : Licensing Agreement

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                            08

                            Selecta Biosciences

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                            AACR Annual meeting
                            Not Confirmed

                            Selecta Biosciences

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                            AACR Annual meeting
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                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sobi and Selecta Biosciences Announce Topline Data of SEL-212 From the Phase 2 COMPARE Study

                            Details : Patients with tophi showed a substantially higher overall response rate for SEL-212 versus pegloticase and a statistically significant overall reduction in mean SUA levels for SEL-212 versus pegloticase.

                            Product Name : SEL-212

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 30, 2020

                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Swedish Orphan Biovitrum AB

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                            AACR Annual meeting
                            Not Confirmed

                            Swedish Orphan Biovitrum AB

                            Sweden arrow
                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Selecta Biosciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            First Patient Randomized in Sobi's Phase 3 DISSOLVE Clinical Program of SEL-212 for Chronic Refractory Gout

                            Details : The phase 3 DISSOLVE clinical programme a randomized double-blind, placebo-controlled study in which SEL-212 will be evaluated at two doses of ImmTOR, and one dose of pegadricase in both studies.

                            Product Name : SEL-212

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            September 23, 2020

                            Lead Product(s) : Pegadricase

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Selecta Biosciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Fuji Yakuhin

                            Japan arrow
                            AACR Annual meeting
                            Not Confirmed

                            Fuji Yakuhin

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                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Dotinurad

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase III

                            Sponsor : Eisai

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Eisai and FUJI YAKUHIN Conclude License Agreement

                            Details : Under this agreement, Eisai will proceed with the development of dotinurad in China.

                            Product Name : Urece

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            February 25, 2020

                            Lead Product(s) : Dotinurad

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase III

                            Sponsor : Eisai

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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