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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The acquisition enhances Roche’s pipeline with therapies in oncology, immunology, and neurology, including P-BCMA-ALLO1, an allogeneic CAR-T, entering donor-derived off-the-shelf cell therapies.

                          Brand Name : P-BCMA-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $1,500.0 million

                          November 26, 2024

                          Lead Product(s) : P-BCMA-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : $1,500.0 million

                          Deal Type : Acquisition

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                          02

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : P-BCMA-ALLO1 is a Phase 1 investigational novel BCMA-targeted allogeneic CAR-T product candidate, targeting B-cell maturation antigen (BCMA) for the treatment of relapsed/refractory multiple myeloma.

                          Brand Name : P-BCMA-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 27, 2024

                          Lead Product(s) : P-BCMA-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : P-BCMA-ALLO1 is a RMAT designated novel BCMA-targeted allogeneic CAR-T product candidate, targeting B-cell maturation antigen for the treatment of relapsed/refractory multiple myeloma.

                          Brand Name : P-BCMA-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 16, 2024

                          Lead Product(s) : P-BCMA-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : P-BCMA-ALLO1 is a Phase 1 investigational novel BCMA-targeted allogeneic CAR-T product candidate, targeting B-cell maturation antigen (BCMA) for the treatment of relapsed/refractory multiple myeloma.

                          Brand Name : P-BCMA-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 13, 2024

                          Lead Product(s) : P-BCMA-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Under the agreement, Astellas gains a right of exclusive negotiation and first refusal to license one of Poseida's clinical stage programs, P-MUC1C-ALLO1, an allogeneic CAR-T cell therapy in development for multiple solid tumor indications.

                          Brand Name : P-MUC1C-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 07, 2023

                          Lead Product(s) : P-MUC1C-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Astellas Pharma

                          Deal Size : $50.0 million

                          Deal Type : Licensing Agreement

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                          06

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : BPX-601 incorporates high-performance GoCAR-T™ technology designed to target and treat solid tumors expressing prostate stem cell antigen (PSCA). It is being discontinued following the company’s assessment of BPX-601 risk/benefit profile in combinati...

                          Brand Name : BPX-601

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 14, 2023

                          Lead Product(s) : BPX-601,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : BPX-601 is our first clinical candidate incorporating our high-performance GoCAR-T™ technology designed to target and treat solid tumors expressing prostate stem cell antigen (PSCA).

                          Brand Name : BPX-601

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          January 19, 2023

                          Lead Product(s) : BPX-601,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          blank

                          08

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Under the agreement with Poseida, Roche to develop allogeneic CAR-T cell therapies for hematologic malignancies, including P-BCMA-ALLO1, an allogeneic CAR-T cell product to treat multiple myeloma, and P-CD19CD20-ALLO1 to treat B cell malignancies.

                          Brand Name : P-BCMA-ALLO1

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $110.0 million

                          August 03, 2022

                          Lead Product(s) : P-BCMA-ALLO1,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : $6,220.0 million

                          Deal Type : Collaboration

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                          09

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The Phase 1 trial is an open label, multi-center, 3+3 dose-escalating study designed to assess the safety of P-PSMA-101 in up to 60 adult subjects with mCRPC. The primary objectives of this study are to determine the safety, efficacy, and maximum tolerat...

                          Brand Name : P-PSMA-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 17, 2022

                          Lead Product(s) : P-PSMA-101,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Proceeds from the financing will be used to support ongoing clinical development of BPX-601 and BPX-603, are designed to be more efficacious CAR-T cell products capable of overriding key immune inhibitory mechanisms.

                          Brand Name : BPX-601

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          December 06, 2021

                          Lead Product(s) : BPX-601,Rimiducid

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : MTS Securities

                          Deal Size : $35.0 million

                          Deal Type : Private Placement

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