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    [{"orgOrder":0,"company":"Elevar Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Rivoceranib","moa":"VEGFR2","graph1":"Oncology","graph2":"Phase I","graph3":"Elevar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Elevar Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Elevar Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Elevar Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Rivoceranib","moa":"VEGFR 2","graph1":"Oncology","graph2":"Phase II","graph3":"Elevar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Medicine"},{"orgOrder":0,"company":"Elevar Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Rivoceranib","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Elevar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Elevar Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Elevar Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Elevar Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Rivoceranib","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Elevar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Resubmits Rivoceranib NDA for Unresectable Hepatocellular Carcinoma

                            Details : Apatinib (rivoceranib) is a highly potent inhibitor of VEGFR-2, which is being evaluated in combination with camrelizumab for the treatment of unresectable hepatocellular carcinoma.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 21, 2024

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            LaNova Medicines

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                            LaNova Medicines

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                            Lead Product(s) : LM-302,Rivoceranib,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Sino Biopharmaceutical

                            Deal Size : $42.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            LaNova Initiates Phase 1 for LM-299 Anti-PD-1/VEGF Antibody and $42M Financing

                            Details : The financing is intended to support the clinical development of LM-302, an anti-CLDN 18.2 ADC, which is currently in late-stage clinical trials in China for the treatment of gastric cancers.

                            Brand Name : LM-302

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 18, 2024

                            Lead Product(s) : LM-302,Rivoceranib,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Sino Biopharmaceutical

                            Deal Size : $42.0 million

                            Deal Type : Series C Financing

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                            03

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Resubmits NDA for Camrelizumab plus Rivoceranib in uHCC

                            Details : Apatinib (rivoceranib) is a highly potent inhibitor of VEGFR-2, which is being evaluated in combination with camrelizumab for the treatment of unresectable hepatocellular carcinoma.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 23, 2024

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics Receives EMA Orphan Designation for Hepatocellular Carcinoma

                            Details : Apatinib (rivoceranib), a small-molecule TKI, is a highly potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), a primary pathway for tumor angiogenesis.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 01, 2024

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Jiangsu Hengrui Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics Plans NDA Resubmission for Hepatocellular Carcinoma Treatment

                            Details : Aitan (rivoceranib), a VEGFR-2 inhibitor, is being investigated with SHR-1210 (camrelizumab) and is already approved in China. The company has resubmitted its NDA to the FDA for unresectable HCC.

                            Brand Name : Aitan

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 09, 2024

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Jiangsu Hengrui Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics Plans NDA Resubmission for Hepatocellular Carcinoma Treatment

                            Details : Apatinib (rivoceranib) is a highly potent inhibitor of VEGFR-2, which is being evaluated in combination with camrelizumab for the treatment of unresectable hepatocellular carcinoma.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 09, 2024

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Jiangsu Hengrui Pharmaceuticals

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                            Jiangsu Hengrui Pharmaceuticals

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                            Lead Product(s) : Camrelizumab,Rivoceranib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Elevar Therapeutics

                            Deal Size : $600.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Jiangsu Hengrui Pharma and Elevar Therapeutics Announce Global Commercialization Licensing Agreement for PD-1 ...

                            Details : Under the agreement, Elevar gain rights to commercialize and develop Hengrui’s anti-PD-1 antibody SHR-1210 (camrelizumab), in combination with rivoceranib (aka apatinib) for unresectable hepatocellular carcinoma worldwide, excluding Greater China Regio...

                            Brand Name : SHR-1210

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 17, 2023

                            Lead Product(s) : Camrelizumab,Rivoceranib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Elevar Therapeutics

                            Deal Size : $600.0 million

                            Deal Type : Licensing Agreement

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                            08

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics to Host August 10 Virtual KOL Event on Phase 3 Study of Rivoceranib in Combination with Ca...

                            Details : Apatinib (rivoceranib), a small-molecule tyrosine kinase inhibitor (TKI), is a highly potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), a primary pathway for tumor angiogenesis.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 03, 2023

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics Announces FDA Acceptance for Filing of New Drug Application for Rivoceranib in Combination...

                            Details : Apatinib (rivoceranib), a small-molecule tyrosine kinase inhibitor (TKI), is a highly potent inhibitor of VEGFR-2, a primary pathway for tumor angiogenesis. VEGFR-2 inhibition is a clinically validated approach to limit tumor growth and disease progressi...

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 17, 2023

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Elevar Therapeutics

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                            Elevar Therapeutics

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                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Jiangsu Hengrui Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Elevar Therapeutics Submits New Drug Application to FDA for Combination of Rivoceranib and Camrelizumab as Fir...

                            Details : Apatinib (rivoceranib) is a tyrosine kinase inhibitor that selectively inhibits the VEGFR-2 in combination with AiRuiKa (camrelizumab) a humanized mAb targeting the PD-1 receptor, is being investigated for unresectable hepatocellular carcinoma.

                            Brand Name : Apatinib

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 17, 2023

                            Lead Product(s) : Rivoceranib,Camrelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Jiangsu Hengrui Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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