Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
iOnctura Commences Randomized Phase II Study in Metastatic Uveal Melanoma
Details : IOA-244 (roginolisib) is an orally dosed small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of metastatic uveal melanoma.
Product Name : IOA-244
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 20, 2025
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Roginolisib,Avelumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iOnctura Reaches New Clinical Milestones in Uveal Melanoma
Details : IOA-244 (roginolisib) is a first-in-class small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of cutaneous melanoma.
Product Name : Undisclosed
Product Type : Small molecule
Upfront Cash : Not Applicable
December 11, 2024
Lead Product(s) : Roginolisib,Avelumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iOnctura Announces Expansion of Roginolisib Clinical Trial Program to NSCLC
Details : IOA-244 (roginolisib) is a first-in-class small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of non-small cell lung cancer.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
July 09, 2024
Lead Product(s) : Roginolisib,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Syncona Limited
Deal Size : $85.9 million
Deal Type : Series B Financing
iOnctura Announces €80 Million Series B Financing to Progress Pipeline Through Phase II
Details : The financing will be used to accelerate the development of IOA-244 (roginolisib), which is being evaluated in the mid-stage clinical trial studies for the treatment of uveal melanoma.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Undisclosed
June 20, 2024
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Syncona Limited
Deal Size : $85.9 million
Deal Type : Series B Financing
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of metastatic uveal melanoma.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
October 31, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class, non-ATP-competitive, allosteric modulator of PI3K delta which prevents tumor proliferation and breaks immune tolerance in patients with solid and hematological tumors.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
March 28, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class, non-ATP-competitive, allosteric modulator of PI3K which prevents tumor proliferation and breaks immune tolerance in patients with solid and hematological tumors.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
March 16, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iOnctura Provides Development Update on First-In-Class Semi-Allosteric PI3Kδ Inhibitor Program
Details : IOA-244 is a first-in-class semi-allosteric, non-ATP competitive, small molecule PI3Kδ inhibitor which has shown high beneficial tolerability and clinical benefit profile. PI3Kδ over-expression stimulates multiple cancer mechanisms and an oncogenic rol...
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
January 05, 2023
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 is a PI3Kδ specific, orally dosed, small molecule inhibitor that overcomes tumor and stroma induced immune suppression. Its unique chemistry, semi allosteric binding mode and mechanism of action contribute to its unprecedented clinical profile.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
May 17, 2022
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Company presenting clinical data on its lead pipeline asset, the PI3K? inhibitor IOA-244, showing no dose-limiting toxicity and a reduction in T regulatory (Treg) cells.
Product Name : IOA-244
Product Type : Small molecule
Upfront Cash : Not Applicable
December 09, 2021
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable