12
ALL12
EpicentRxYear
12
ALL5
20236
20221
2020DEALS // DEV.
12
ALL4
Deals8
DevelopmentsCountry
12
ALL12
U.S.A12
ALL1
Dana-Farber Cancer Institute1
FightMND7
Inapplicable1
Sciclone Pharmaceuticals1
Texas Children’s Hospital1
The Michael J. Fox Foundation for Parkinson’s ResearchTherapeutic Area
12
ALL4
Gastroenterology2
Neurology6
OncologyStudy Phase
12
ALL2
Phase III6
Phase II2
Phase I2
PreclinicalDeal Type
12
ALL1
Collaboration2
Funding8
Inapplicable1
Licensing AgreementProduct Type
12
ALL12
Other Small MoleculeDosage Form
12
ALL3
Intravenous Infusion7
Intravenous Injection2
UndisclosedLead Product
12
ALL12
RRx-001Target
12
ALL12
CD47Details : RRx-001 (nibrozetone) is a multifaceted small molecule inflammasome NLRP3/KEAP1 inhibitor with tumor-targeted cytotoxicity and healthy tissue cytoprotective properties, which is investigated for the treatment of small cell lung cancer.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 07, 2023
Lead Product(s) : RRx-001
Therapeutic Area : Gastroenterology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies. It is under investigation SCLC, head and neck cancer.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 29, 2023
Lead Product(s) : RRx-001
Therapeutic Area : Gastroenterology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RRx-001 plus opdivo (nivolumab) as a combinaton is being investigated for advanced checkpoint inhibitor non-responsive tumors, where RRx-001 is a highly selective NLRP3 inhibitor and nivolumab monoclonal antibody that targets the anti-PD1 receptor.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 15, 2023
Lead Product(s) : RRx-001,Bevacizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors. RRx-001 is under investigation for SCLC and for protection against oral mucositis in first line he...
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 20, 2023
Lead Product(s) : RRx-001,Bevacizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies. It is under investigation SCLC, head and neck cancer.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 19, 2023
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : RRx-001,Bevacizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 14, 2022
Lead Product(s) : RRx-001,Bevacizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : RRx-001
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : The Michael J. Fox Foundation for Parkinson’s Research
Deal Size : $0.5 million
Deal Type : Funding
Details : RRx-001, a direct NLRP3 inflammasome inhibitor, will be evaluated for its potential to reduce or reverse the pathological features and hallmark symptoms of PD.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
December 07, 2022
Lead Product(s) : RRx-001
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : The Michael J. Fox Foundation for Parkinson’s Research
Deal Size : $0.5 million
Deal Type : Funding
Lead Product(s) : RRx-001
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : FightMND
Deal Size : $0.5 million
Deal Type : Funding
Details : FightMND to evaluate the potential neuroprotective benefits of the company's lead small molecule, RRx-001. RRx-001, a direct NLRP3 inflammasome inhibitor, will be evaluated as a novel disease modifying therapy for MND.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
November 29, 2022
Lead Product(s) : RRx-001
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : FightMND
Deal Size : $0.5 million
Deal Type : Funding
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
EpicentRx Announces Patent Issued for Radiation Protection with RRx-001 in Combination Regimens
Details : The potential of RRx-001 as a radiation protection agent is related to evidence of NLRP3 inflammasome inhibition and Nrf2 activation, reducing the toxicity of radiation through the suppression of inflammation, free radical and oxidative stress.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 12, 2022
Lead Product(s) : RRx-001,Cisplatin
Therapeutic Area : Gastroenterology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : RRx-001,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Texas Children’s Hospital
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The genesis for the PIRATE trial was based on several preceding clinical trials which have established potential evidence that RRx-001 increases chemotherapy delivery and uptake in tumors.
Product Name : RRx-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 23, 2022
Lead Product(s) : RRx-001,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Texas Children’s Hospital
Deal Size : Undisclosed
Deal Type : Collaboration