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01

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Details : RRx-001 (nibrozetone) is a multifaceted small molecule inflammasome NLRP3/KEAP1 inhibitor with tumor-targeted cytotoxicity and healthy tissue cytoprotective properties, which is investigated for the treatment of small cell lung cancer.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 07, 2023

Lead Product(s) : RRx-001,Cisplatin

Therapeutic Area : Oncology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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02

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Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies. It is under investigation SCLC, head and neck cancer.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 29, 2023

Lead Product(s) : RRx-001

Therapeutic Area : Gastroenterology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

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Details : RRx-001 plus opdivo (nivolumab) as a combinaton is being investigated for advanced checkpoint inhibitor non-responsive tumors, where RRx-001 is a highly selective NLRP3 inhibitor and nivolumab monoclonal antibody that targets the anti-PD1 receptor.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 15, 2023

Lead Product(s) : RRx-001,Nivolumab

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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04

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Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors. RRx-001 is under investigation for SCLC and for protection against oral mucositis in first line he...

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 20, 2023

Lead Product(s) : RRx-001,Bevacizumab

Therapeutic Area : Oncology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

AAN
Not Confirmed
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Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies. It is under investigation SCLC, head and neck cancer.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 19, 2023

Lead Product(s) : RRx-001,Cisplatin

Therapeutic Area : Gastroenterology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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06

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Not Confirmed
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Not Confirmed

Details : RRx-001 is a highly selective NLRP3 inhibitor with vascular normalization and tumor associated macrophage polarization properties that resensitizes tumors to previously administered therapies.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

December 14, 2022

Lead Product(s) : RRx-001,Bevacizumab

Therapeutic Area : Oncology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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07

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Not Confirmed
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Details : RRx-001, a direct NLRP3 inflammasome inhibitor, will be evaluated for its potential to reduce or reverse the pathological features and hallmark symptoms of PD.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

December 07, 2022

Lead Product(s) : RRx-001

Therapeutic Area : Neurology

Highest Development Status : Preclinical

Sponsor : The Michael J. Fox Foundation for Parkinson’s Research

Deal Size : $0.5 million

Deal Type : Funding

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08

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Details : FightMND to evaluate the potential neuroprotective benefits of the company's lead small molecule, RRx-001. RRx-001, a direct NLRP3 inflammasome inhibitor, will be evaluated as a novel disease modifying therapy for MND.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

November 29, 2022

Lead Product(s) : RRx-001

Therapeutic Area : Neurology

Highest Development Status : Preclinical

Sponsor : FightMND

Deal Size : $0.5 million

Deal Type : Funding

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09

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Not Confirmed
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Details : The potential of RRx-001 as a radiation protection agent is related to evidence of NLRP3 inflammasome inhibition and Nrf2 activation, reducing the toxicity of radiation through the suppression of inflammation, free radical and oxidative stress.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 12, 2022

Lead Product(s) : RRx-001,Cisplatin

Therapeutic Area : Gastroenterology

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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10

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Not Confirmed
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Details : The genesis for the PIRATE trial was based on several preceding clinical trials which have established potential evidence that RRx-001 increases chemotherapy delivery and uptake in tumors.

Product Name : RRx-001

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

February 23, 2022

Lead Product(s) : RRx-001,Irinotecan Hydrochloride

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Texas Children’s Hospital

Deal Size : Undisclosed

Deal Type : Collaboration

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