Lead Product(s) : RVU120
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Ryvu Therapeutics
Deal Size : $1.0 million
Deal Type : Agreement
Details : RVU120 is a selective, first-in-class dual CDK8/CDK19 kinase inhibitor that has shown signs of clinical activity in treated patients, as well as efficacy in numerous in vitro and in vivo models of hematologic malignancies and solid tumors.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 06, 2023
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Ryvu Therapeutics
Deal Size : $1.0 million
Deal Type : Agreement
Ryvu Doses First Patient in REMARK Phase II Study of RVU120 for Anemia
Details : RVU120 is a first-in-class dual CDK8/19 kinase inhibitor. The study aims to treat anemia in patients with lower-risk myelodysplastic syndromes.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 19, 2024
Ryvu Doses First Patient in RIVER-52 Phase II Study of RVU120 for Relapsed/Refractory AML
Details : RVU120 is a selective, first-in-class dual CDK8/19 kinase inhibitor. It is being developed for patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 14, 2024
Lead Product(s) : RVU120,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Ryvu Doses First Patient in RIVER-81 Phase II Study of RVU120 with Venetoclax for AML
Details : RVU120 is a selective, first-in-class dual CDK8/19 kinase inhibitor. It is being evaluated in phase 2 clinical trials in combination with venetoclax for patients with relapsed/refractory AML.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 31, 2024
Lead Product(s) : RVU120,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Expansion of Clinical Development of RVU120 in Low-Risk Myelodysplastic Syndromes (LR-MDS)
Details : RVU120 is a selective CDK8/CDK19 kinase inhibitor with potential for the treatment of hematological malignancies and solid tumors currently in phase I clinical development for the treatment of acute myeloid leukemia and myelodysplastic syndromes.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 20, 2023
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $57.2 million
Deal Type : Public Offering
Ryvu Therapeutics Announces Closing of Equity Offering with Gross Proceeds Over PLN 250 Million
Details : RVU120, a selective CDK8/CDK19 kinase inhibitor with potential for the treatment of hematological malignancies and solid tumors, is currently in phase I clinical development for the treatment of acute myeloid leukemia and myelodysplastic syndrome.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 22, 2022
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $57.2 million
Deal Type : Public Offering
Details : RVU120 (SEL120) is a small molecule selective CDK8 kinase inhibitor in clinical development for the treatment of acute myeloid leukemia and high-risk myelodysplastic syndromes, as well as solid tumors.
Brand Name : SEL120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 26, 2022
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Preclinical data demonstrate that treatment with RVU120, a small molecule inhibitor of CDK8/19 kinases, in combination with an anti-CD20 antibody causes upregulation of LAMP1 surface level and increases NK cell cytotoxicity against CD20-positive positive...
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 12, 2022
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : European Investment Bank
Deal Size : $21.8 million
Deal Type : Financing
Details : Ryvu aims to address the clinical limitations of current treatments in oncology and provide patients with access to innovative therapies RVU120, for the treatment of haematologic and solid tumours.
Brand Name : RVU120
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 17, 2022
Lead Product(s) : RVU120
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : European Investment Bank
Deal Size : $21.8 million
Deal Type : Financing
Details : RVU120 (SEL120) is a clinical-stage, highly specific, and orally bioavailable dual inhibitor of CDK8/CDK19 kinases, which has demonstrated efficacy in a number of solid tumor in vitro and in vivo models as well as in hematologic malignancies.
Brand Name : SEL120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 27, 2022
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