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Study","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"Approved","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"G1 Therapeutics, Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Trilaciclib Combined with ADC Shows Improved Survival and Tolerability in Patients","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"May 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Gilead Sciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Gilead Provides Update on Phase 3 TROPiCS-04 Study","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase 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Find Clinical Drug Pipeline Developments & Deals for Sacituzumab Govitecan
IDE397 is a potential first-in-class small molecule MAT2A inhibitor, which is being evaluated in combination with Trodelvy for the treatment of MTAP-deletion bladder cancer.
Company announced Phase 3 study of Trodelvy® (sacituzumab govitecan, ADC) in combination with chemotherapy in locally advanced or metastatic urothelial cancer.
The collaboration aims to evaluate the safety and efficacy of Debio 0123, Debiopharm's investigational, potential best-in-class WEE1 inhibitor, together with Trodelvy (sacituzumab govitecan).
Cosela (trilaciclib) CDK4/CDK6 inhibitor is being evaluated in combination with a TROP2 ADC sacituzumab govitecan for the treatment of Triple Negative Breast Cancer.
The financing aims to support the company in the clinical development of Trodelvy (sacituzumab govitecan), rop-2 directed antibody-drug conjugate. It is being evaluated for the treatment of Non-Small Cell Lung Cancer.
The collaboration is designed to evaluate and combine DF1001, which is a new molecule that targets natural killer cells and T-cell activation signals, with Gilead's Trop-2-directed antibody-drug conjugate in the treatment of metastatic breast and non-small cell lung cancer.
Trodelvy (sacituzumab govitecan-hziy) is the first approved Trop-2-directed antibody-drug conjugate which is under phase 3 clinical trials for the treatment of metastatic or advanced Non-Small Cell Lung Cancer.
Trodelvy® (sacituzumab govitecan-hziy) is a first-in-class Trop-2 directed antibody-drug conjugate, approved for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-negative breast cancer.
Trodelvy (sacituzumab govitecan-hziy) is a first-in-class Trop-2 directed antibody-drug conjugate. Trop-2 is a cell surface antigen highly expressed in multiple tumor types, including in more than 90% of breast and bladder cancers.
The data highlight the potential for G1T28 (trilaciclib) to meaningfully reduce adverse events related to use of sacituzumab. As expected, patients with PD-L1(+) tumors appear to respond earlier than patients with PD-L1(-) tumors.