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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the collaboration, Sanofi has exercised its option for a second target as part of the companies' research collaboration to develop CRISPR-based therapeutics using Scribe’s CRISPR technologies.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $40.0 million

                          January 03, 2024

                          Lead Product(s) : CRISPR-based Therapy

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Discovery

                          Sponsor : Sanofi

                          Deal Size : $1,240.0 million

                          Deal Type : Expanded Collaboration

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the collaboration, Sanofi receives an exclusive license to use Scribe’s CRISPR X-Editing (XE) genome editing technologies for the development of in vivo NK-cell therapies, including sickle cell disease.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $40.0 million

                          July 17, 2023

                          Lead Product(s) : Ex-vivo NK Cell Therapy

                          Therapeutic Area : Hematology

                          Highest Development Status : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $1,240.0 million

                          Deal Type : Expanded Collaboration

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the collaboration, Prevail gets exclusive rights to Scribe’s CRISPR X-Editing (XE) technologies for the development of in vivo therapies directed to specified genetic targets known to cause serious neurological and neuromuscular diseases.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $75.0 million

                          May 16, 2023

                          Lead Product(s) : CRISPR-based Genetic Medicine

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Prevail Therapeutics

                          Deal Size : $1,575.0 million

                          Deal Type : Collaboration

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The agreement grants Sanofi non-exclusive rights to Scribe’s proprietary CRISPR platform of wholly owned enzymes to create ex vivo NK cell therapies for multiple oncology targets.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $25.0 million

                          September 27, 2022

                          Lead Product(s) : NK Cell Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : Sanofi

                          Deal Size : $1,025.0 million

                          Deal Type : Collaboration

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The expanded collaboration further validates Scribe’s position as a leading organization driving the development of novel CRISPR-based therapeutics that treat the underlying cause of disease.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          May 02, 2022

                          Lead Product(s) : CRISPR-based Therapeutic

                          Therapeutic Area : Neurology

                          Highest Development Status : Undisclosed

                          Sponsor : Biogen

                          Deal Size : Undisclosed

                          Deal Type : Expanded Collaboration

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The capital will be used to further develop Scribe’s suite of custom gene editing and delivery technologies, as well as to advance a pipeline of therapeutics for neurodegeneration and additional diseases with high unmet need.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 31, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Sponsor : Avoro Ventures

                          Deal Size : $100.0 million

                          Deal Type : Series B Financing

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the terms of the collaboration, Scribe will work with Biogen to create therapeutics for genetically-driven ALS, with an option to pursue an additional neurological disease target with high, unmet need.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $15.0 million

                          October 06, 2020

                          Lead Product(s) : CRISPR based gene therapy

                          Therapeutic Area : Neurology

                          Highest Development Status : Undisclosed

                          Sponsor : Biogen

                          Deal Size : $415.0 million

                          Deal Type : Collaboration

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