Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Descartes-08
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Cartesian Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Selecta Biosciences Announces Merger with Cartesian Therapeutics
Details : The net proceeds will support the development of the Cartesian pipeline through the Phase 3 study of lead product candidate, Descartes-08, a potential first-in-class RNA-engineered chimeric antigen receptor T-cell therapy (rCAR-T) for the treatment of my...
Brand Name : Descartes-08
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
November 13, 2023
Lead Product(s) : Descartes-08
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Cartesian Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Descartes-08
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Leerink Partners
Deal Size : $60.2 million
Deal Type : Private Placement
Selecta Biosciences Announces Merger with Cartesian Therapeutics
Details : The combined company will focus on the development of the Cartesian pipeline through the Phase 3 study of lead product candidate, Descartes-08, a potential first-in-class RNA-engineered chimeric antigen receptor T-cell therapy (rCAR-T) for the treatment ...
Brand Name : Descartes-08
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
November 13, 2023
Lead Product(s) : Descartes-08
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Leerink Partners
Deal Size : $60.2 million
Deal Type : Private Placement
Lead Product(s) : Pegadricase,ImmTOR
Therapeutic Area : Rheumatology
Study Phase : Phase III
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $705.0 million
Deal Type : Licensing Agreement
Details : Sobi will transition the manufacturing and development rights of ImmTOR for SEL-212 to Sobi. SEL-212, a combination of Selecta’s ImmTOR immune tolerance platform and a therapeutic uricase enzyme (pegadricase), is in development for chronic refractory g...
Brand Name : SEL-212
Molecule Type : Large molecule
Upfront Cash : $75.0 million
October 31, 2023
Lead Product(s) : Pegadricase,ImmTOR
Therapeutic Area : Rheumatology
Highest Development Status : Phase III
Sponsor : Swedish Orphan Biovitrum AB
Deal Size : $705.0 million
Deal Type : Licensing Agreement
Lead Product(s) : SEL-037,SEL-110
Therapeutic Area : Rheumatology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Phase 3 DISSOLVE Program of SEL-212 in Chronic Refractory Gout Meets Primary Endpoint
Details : SEL-212 (combination of ImmTOR immune tolerance platform and pegadricase) is designed to reduce serum urate levels in people with chronic refractory gout, potentially reducing harmful tissue urate deposits which causes debilitating gout flares and joint ...
Brand Name : SEL-212
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 21, 2023
Lead Product(s) : SEL-037,SEL-110
Therapeutic Area : Rheumatology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xork,AT845
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Astellas Pharma
Deal Size : $350.0 million
Deal Type : Licensing Agreement
Details : SEL-018 (xork) is being studied as a potential next generation immunoglobulin G (IgG) protease that will be developed by Astellas for use with AT845, an investigational, adeno-associated virus (AAV)-based treatment for Late-Onset Pompe disease (LOPD) in ...
Brand Name : SEL-018
Molecule Type : Large molecule
Upfront Cash : $10.0 million
January 09, 2023
Lead Product(s) : Xork,AT845
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Astellas Pharma
Deal Size : $350.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Undisclosed
Therapeutic Area : Nephrology
Study Phase : Preclinical
Recipient : IGAN Biosciences
Deal Size : $1.6 million
Deal Type : Licensing Agreement
Details : The selection of a next generation Immunoglobulin A (IgA) protease from IGAN Biosciences for its IgA nephropathy (IgAN) program, will lead Selecta Biosciences to pay IGAN Biosciences.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Undisclosed
December 14, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Nephrology
Highest Development Status : Preclinical
Recipient : IGAN Biosciences
Deal Size : $1.6 million
Deal Type : Licensing Agreement
Lead Product(s) : SEL-302
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SEL-302 is Adeno-Associated Virus (AAV) sterotype which consists of MMA-101 plus ImmTOR for the treatment of patients with methylmalonic acidemia (MMA).
Brand Name : SEL-302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 11, 2022
Lead Product(s) : SEL-302
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SEL-302
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SEL-302 comprises ImmTOR in combination with MMA-101, and has the potential to mitigate unwanted immunogenicity to treat individuals with methylmalonic acidemia.
Brand Name : SEL-302
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 02, 2022
Lead Product(s) : SEL-302
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Immunoglobulin G Protease
Therapeutic Area : Immunology
Study Phase : Preclinical
Recipient : Genovis
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Details : The partnership leverages Genovis’ proprietary immunoglobulin G protease, IdeXork, and Selecta’s ImmTOR platform to enable the dosing of transformative gene therapies in patients with pre-existing adeno-associated virus immunity and treat IgG-mediate...
Brand Name : IdeXork
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 21, 2021
Lead Product(s) : Immunoglobulin G Protease
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Recipient : Genovis
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : VTX-803,ImmTOR
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Selecta Biosciences to Present New Data for the ImmTOR™ platform at the ESGCT 28th Annual Congress
Details : Re-administration of AAV expressing MDR3 (VTX-803) treats progressive familial intrahepatic cholestasis type 3 (PFIC3) in juvenile Abcb4 -/- mice when co-administered with ImmTOR.
Brand Name : VTX-803
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 13, 2021
Lead Product(s) : VTX-803,ImmTOR
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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