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Find Clinical Drug Pipeline Developments & Deals for Selinexor

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of adult patients with multiple myeloma.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          March 04, 2025

                          Lead Product(s) : Selinexor,Bortezomib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Phase 3 clinical trial evaluating a once-weekly dose of 60mg of Xpovio (selinexor) in combination with twice-daily ruxolitinib in treatment naïve patients with myelofibrosis.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : Selinexor,Ruxolitinib Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : XPOVIO (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          October 17, 2024

                          Lead Product(s) : Selinexor,Bortezomib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Xpovio (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 24, 2024

                          Lead Product(s) : Selinexor,Bortezomib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : XPOVIO® (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 08, 2024

                          Lead Product(s) : Selinexor,Bortezomib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Xpovio (selinexor) is an approved, first-in-class, small molecule, exportin 1 inhibitor. It is given orally to adult patients for the treatment of relapsed/refractory diffuse large B-cell lymphoma.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 07, 2024

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor, which is currently being evaluated for the treatment of TP53 wild-type advanced or recurrent endometrial cancer.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          March 12, 2024

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : The collaboratin aims to evaluate the investigational cereblon E3 ligase modulator agent mezigdomide in combination with Karyopharm's selinexor, an approved first-in-class inhibitor of XPO1, plus dexamethasone in patients with relapsed/refractory multipl...

                          Product Name : BMS-986348

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 30, 2023

                          Lead Product(s) : Mezigdomide,Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Karyopharm Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details :

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : $27.6 million

                          October 08, 2023

                          Lead Product(s) : Selinexor,Dexamethasone

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Hansoh Pharma

                          Deal Size : $101.5 million

                          Deal Type : Collaboration

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                          10

                          Peptide Therapy Summit
                          Not Confirmed
                          Peptide Therapy Summit
                          Not Confirmed

                          Details : Xpovio (selinexor) is a first-in-class, oral exportin 1 (XPO1) inhibitor and the first of Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds to be approved for the treatment of cancer.

                          Product Name : Xpovio

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Undisclosed

                          October 01, 2023

                          Lead Product(s) : Selinexor

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Karyopharm Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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