Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Regeneron Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-101 is a conditionally active, human monoclonal IgG1 antibody, designed to selectively block the immune checkpoint VISTA in the tumor microenvironment, which acts as a suppressor of T cells by binding the receptor PSGL-1.
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 27, 2023
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Regeneron Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-101 is a conditionally active, human monoclonal IgG1 antibody, designed to selectively block the immune checkpoint VISTA in the tumor microenvironment, which acts as a suppressor of T cells by binding the receptor PSGL-1.
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 01, 2023
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-101 is a conditionally active, human monoclonal IgG1 antibody designed to block the VISTA checkpoint, which acts as a suppressor of T cells by binding the receptor PSGL-1. SNS-101 addresses the problems by binding only in the low-pH tumor microenviro...
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 20, 2023
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-101 is a conditionally active, human monoclonal IgG1 antibody designed to block the VISTA checkpoint, which acts as a suppressor of T cells by binding the receptor PSGL-1. SNS-101 addresses the problems by binding only in the low-pH tumor microenviro...
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 21, 2023
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-103
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-103 is a conditionally active, monoclonal antibody targeting ENTPDase1 (CD39), an enzyme commonly upregulated by tumors and involved in the conversion of ATP into immunosuppressive adenosine in the tumor microenvironment.
Brand Name : SNS-103
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 14, 2023
Lead Product(s) : SNS-103
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SNS-101 is a conditionally active, human monoclonal IgG1 antibody designed to block the VISTA checkpoint, which acts as a suppressor of T cells by binding the receptor PSGL-1. SNS-101 addresses the problems by binding only in the low-pH tumor microenviro...
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 14, 2023
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the terms of the CRADA, Sensei will collaborate with the NCI to expand the development of SNS-101, a conditionally active, pH-selective VISTA-blocking antibody and to assess the mechanism of action of SNS-101 in combination with novel therapeutic m...
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Undisclosed
February 06, 2023
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Regeneron Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Agreement
Details : The supply agreement supports the evaluation of SNS-101, a conditionally active VISTA-blocking antibody, in combination with Libtayo® in a Phase 1/2 trial in solid tumors.
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 05, 2023
Lead Product(s) : SNS-101,Cemiplimab
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Regeneron Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sensei Biotherapeutics Provides Update on Strategic Priorities
Details : SNS-101, a conditionally active antibody targeting the immune checkpoint VISTA, as well as its other TMAb™ (Tumor Microenvironment Activated biologics) platform programs.
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Not Applicable
December 08, 2022
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Washington University
Deal Size : Undisclosed
Deal Type : Collaboration
Details : SNS-101 has the potential to unlock VISTA as a powerful immune checkpoint by exploiting the tumor microenvironment using pH-sensitive properties, delivering powerful anti-tumor activity without the negative effects that have thwarted past efforts.
Brand Name : SNS-101
Molecule Type : Large molecule
Upfront Cash : Undisclosed
November 21, 2022
Lead Product(s) : SNS-101
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Washington University
Deal Size : Undisclosed
Deal Type : Collaboration
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