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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Peptide","year":"2025","type":"Termination","leadProduct":"Setmelanotide Acetate","moa":"MC4R","graph1":"Nutrition and Weight Loss","graph2":"Approved FDF","graph3":"RareStone Group","amount2":0.01,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.01,"dosageForm":"Subcutaneous Injection","sponsorNew":"RareStone Group \/ Rhythm Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"RareStone Group \/ Rhythm Pharmaceuticals"}]

Find Clinical Drug Pipeline Developments & Deals for Setmelanotide Acetate

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01

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Through the termination, Rhythm will reacquires the rights of Imcivree (setmelanotide acetate). It is being indicated for the treatment of obesity.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : $6.3 million

March 20, 2025

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Nutrition and Weight Loss

Highest Development Status : Approved FDF

Sponsor : Rhythm Pharmaceuticals

Deal Size : $6.3 million

Deal Type : Termination

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02

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a subcutaneously administered, MC4 R agonist. It is being investigated for the treatment of acquired hypothalamic obesity.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Inapplicable

March 19, 2025

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Nutrition and Weight Loss

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the approved weight management treatment in pediatric patients (2-6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Undisclosed

Product Type : Peptide

Upfront Cash : Not Applicable

December 20, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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04

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the approved weight management treatment in pediatric patients (2-6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Undisclosed

Product Type : Peptide

Upfront Cash : Not Applicable

December 03, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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05

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the approved weight management treatment in pediatric patients (2-6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Not Applicable

August 26, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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06

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the approved weight management treatment in pediatric patients (2-6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Not Applicable

July 31, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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07

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the 1st & only therapy approved in Canada for weight management in adult & pediatric patients (≥6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Not Applicable

June 28, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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08

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 R agonist. It is the 1st & only therapy approved in Canada for weight management in adult & pediatric patients (≥6 years) with obesity due to Bardet-Biedl syndrome.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Not Applicable

May 22, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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09

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : The Company intends to use the proceeds to fund clinical programs, including IMCIVREE, an MC4R agonist for treating hyperphagia and severe obesity, approved for chronic weight management.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Undisclosed

April 01, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Sponsor : Perceptive Advisors LLC

Deal Size : $150.0 million

Deal Type : Financing

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10

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Imcivree (setmelanotide) is a MC4 receptor agonist for chronic weight management in patients 6 years and older with monogenic or syndromic obesity, under evaluation for hypothalamic obesity.

Product Name : Imcivree

Product Type : Peptide

Upfront Cash : Not Applicable

February 22, 2024

Lead Product(s) : Setmelanotide Acetate

Therapeutic Area : Nutrition and Weight Loss

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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