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Find Clinical Drug Pipeline Developments & Deals by SIGA Technologies

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                          Top Deals by Deal Size (USD bn)

                          01

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : SIGA gains the exclusive rights for a portfolio of preclinical fully human mAbs which could be used as potential treatments for a broad range of orthopoxviruses, including smallpox and mpox.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 22, 2024

                          Lead Product(s) : Monoclonal Antibody-based Therapy

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : Vanderbilt University

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The agreement aims for the procurement of Tpoxx (tecovirimat), an antiviral, approved in the US and Canada for the treatment of smallpox and authorized in EU and the UK for smallpox, mpox and cowpox.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 21, 2024

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : U.S. Department of Defense

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          03

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Tpoxx (tecovirimat) is an oral orthopoxvirus VP37 envelope-wrapping protein inhibitor, Currently, it is being evaluated in the mid-stage clinical trial for the treatment of Monkeypox Virus.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 15, 2024

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The agreement aims to expand access to Tpoxx (tecovirimat), a novel small-molecule drug for the treatment of smallpox, to the member states in the ASEAN.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 17, 2024

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : ASEAN

                          Deal Size : Undisclosed

                          Deal Type : Divestment

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                          05

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The collaboration aims to support the development of Calidi’s systemic and targeted RTNova (CLD-400) virotherapy platform, which has the potential to provide a universal treatment for all tumor types.

                          Brand Name : CLD-400

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 10, 2024

                          Lead Product(s) : CLD-400

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : Calidi Biotherapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : SIGA will lead international promotions for oral TPOXX, an FDA-approved drug for smallpox, while maintaining its contractual relationship with Meridian to ensure continuity for key customers.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 01, 2024

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Recipient : Meridian Medical Technologies

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          07

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TPOXX (tecovirimat), also known as tecovirimat and ST-246®, an orally administered and IV formulation antiviral drug for the treatment of human smallpox disease caused by variola virus.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 12, 2022

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TPOXX is a powerful antiviral drug to vaccinia and allows the safe use of higher doses of vaccinia vectors, there is also the potential it could increase immunotherapeutic outcomes.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          July 15, 2022

                          Lead Product(s) : Vaccinia-based Cancer Therapy,Tecovirimat

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : KaliVir Immunotherapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TPOXX (tecovirimat, ST-246®), a novel small-molecule drug, is an orthopoxvirus VP37 envelope wrapping protein inhibits the viral maturation of variola virus and other poxviruses by preventing the formation of a secondary viral envelope.

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 08, 2022

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Catalent Pharma Solutions

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TPOXX®, also known as tecovirimat and ST-246®, an orally administered and IV formulation antiviral drug for the treatment of human smallpox disease caused by variola virus. TPOXX is a novel small-molecule drug and the US maintains a supply of TPOXX und...

                          Brand Name : Tpoxx

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 19, 2022

                          Lead Product(s) : Tecovirimat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Patheon

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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