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Find Clinical Drug Pipeline Developments & Deals by Simcha Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : ST-067 (vevoctadekin) is a decoy-resistant interleukin-18 stimulator, which is currently being evaluated for the treatment of patients with acute myeloid leukemia.

                          Product Name : ST-067

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          December 05, 2024

                          Lead Product(s) : Vevoctadekin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Under the terms of the agreement, Janssen will develop, manufacture, and commercialize CAR T-based cell therapy candidates with Simcha’s novel proprietary DR-18 for a set number of programs.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 01, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : JANSSEN BIOTECH

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The collaboration aims to evaluate clinical safety and benefits of ST-067, Simcha’s decoy resistant IL-18 agent, in combination with Merck's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), in patients with solid tumors.

                          Product Name : ST-067

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          May 04, 2023

                          Lead Product(s) : Vevoctadekin,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Merck & Co

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : In addition, the Company has dosed the first patient in the Phase 1 portion of a first-in human multi-center Phase 1/2 clinical trial of its first drug candidate ST-067, a first-in-class “decoy-resistant” Interleukin-18 variant.

                          Product Name : ST-067

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          January 27, 2022

                          Lead Product(s) : Vevoctadekin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : BVF Partners

                          Deal Size : $40.0 million

                          Deal Type : Series B Financing

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Simcha’s lead program involves a customized variant of interleukin-18 (IL-18), a cytokine with potent antitumor effects, developed in the lab of Scientific Founder Aaron Ring, M.D., Ph.D., Assistant Professor of Immunobiology at the Yale School of Medi...

                          Product Name : ST-067

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          June 24, 2020

                          Lead Product(s) : Vevoctadekin

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : WuXi AppTec

                          Deal Size : $25.0 million

                          Deal Type : Series A Financing

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Oral presentation and poster detail DR-18’s ability to re-animate exhausted NK cells, bias differentiation of T cells toward highly active effectors and expand the population of critical immune cells inside the tumor microenvironment.

                          Product Name : DR-18

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          June 24, 2020

                          Lead Product(s) : DR-18

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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