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Find Clinical Drug Pipeline Developments & Deals by Sionna Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Details : Under the terms of the agreement, Sionna will assume all development for ABBV-2222 (galicaftor), which is being evaluated in combination with navocaftor for the treatment of Cystic Fibrosis.

                          Product Name : ABBV-2222

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 16, 2024

                          Lead Product(s) : Galicaftor,Navocaftor

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Recipient : AbbVie Inc

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Enavate Sciences

                          Deal Size : $182.0 million

                          Deal Type : Series C Financing

                          Details : The net proceeds will be used to support the clinical development of first-in-class small molecule, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regula...

                          Product Name : SION-638

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 06, 2024

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Enavate Sciences

                          Deal Size : $182.0 million

                          Deal Type : Series C Financing

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                          03

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : SION-109

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : SION-109 is a small molecule designed to target the interface between the ICL4 region and the first NBD1 of the CFTR protein. It is under phase 1 clinical development for the treatment of delta-F508 mutat...

                          Product Name : SION-109

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 24, 2024

                          Lead Product(s) : SION-109

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : SION-638, a novel small molecule designed to target the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

                          Product Name : SION-638

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 07, 2022

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Partner/Sponsor/Collaborator : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          26th North American ISSX
                          Not Confirmed
                          26th North American ISSX
                          Not Confirmed

                          Lead Product(s) : SION-638,Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Partner/Sponsor/Collaborator : OrbiMed

                          Deal Size : $111.0 million

                          Deal Type : Series B Financing

                          Details : Sionna is advancing a pipeline of first-in-class small molecules, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is defecti...

                          Product Name : SION-638

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 19, 2022

                          Lead Product(s) : SION-638,Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Partner/Sponsor/Collaborator : OrbiMed

                          Deal Size : $111.0 million

                          Deal Type : Series B Financing

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