Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Galicaftor,Navocaftor
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Recipient : AbbVie Inc
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Sionna Expands CF Pipeline with AbbVie License Agreement
Details : Under the terms of the agreement, Sionna will assume all development for ABBV-2222 (galicaftor), which is being evaluated in combination with navocaftor for the treatment of Cystic Fibrosis.
Product Name : ABBV-2222
Product Type : Small molecule
Upfront Cash : Undisclosed
July 16, 2024
Lead Product(s) : Galicaftor,Navocaftor
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Recipient : AbbVie Inc
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : SION-638
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Enavate Sciences
Deal Size : $182.0 million
Deal Type : Series C Financing
Details : The net proceeds will be used to support the clinical development of first-in-class small molecule, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regula...
Product Name : SION-638
Product Type : Small molecule
Upfront Cash : Undisclosed
March 06, 2024
Lead Product(s) : SION-638
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Enavate Sciences
Deal Size : $182.0 million
Deal Type : Series C Financing
Lead Product(s) : SION-109
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sionna Therapeutics Announces Phase 1 Initiation for SION-109 in Cystic Fibrosis
Details : SION-109 is a small molecule designed to target the interface between the ICL4 region and the first NBD1 of the CFTR protein. It is under phase 1 clinical development for the treatment of delta-F508 mutat...
Product Name : SION-109
Product Type : Small molecule
Upfront Cash : Not Applicable
January 24, 2024
Lead Product(s) : SION-109
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SION-638
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Sionna Therapeutics Announces IND Clearance and Phase 1 Initiation for SION-638 in Cystic Fibrosis
Details : SION-638, a novel small molecule designed to target the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
Product Name : SION-638
Product Type : Small molecule
Upfront Cash : Not Applicable
December 07, 2022
Lead Product(s) : SION-638
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SION-638,Undisclosed
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Partner/Sponsor/Collaborator : OrbiMed
Deal Size : $111.0 million
Deal Type : Series B Financing
Details : Sionna is advancing a pipeline of first-in-class small molecules, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is defecti...
Product Name : SION-638
Product Type : Small molecule
Upfront Cash : Undisclosed
April 19, 2022
Lead Product(s) : SION-638,Undisclosed
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Partner/Sponsor/Collaborator : OrbiMed
Deal Size : $111.0 million
Deal Type : Series B Financing
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