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    [{"orgOrder":0,"company":"Skye Bioscience","sponsor":"ProSciento","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Nimacimab","moa":"CB1","graph1":"Nephrology","graph2":"Phase II","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Skye Bioscience \/ ProSciento","highestDevelopmentStatusID":"8","companyTruncated":"Skye Bioscience \/ ProSciento"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"9-delta-Tetrahydrocannabinol-valine-hemisuccinate","moa":"CB receptor","graph1":"Ophthalmology","graph2":"Preclinical","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"","sponsorNew":"Skye Bioscience \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Skye Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Tetrahydrocannabinol","moa":"CB1","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Topical","sponsorNew":"Skye Bioscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Not 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I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Nanoemulsion","sponsorNew":"Skye Bioscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Tetrahydrocannabinol","moa":"CB receptor","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Nanoemulsion","sponsorNew":"Skye Bioscience \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Skye 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Applicable","highestDevelopmentStatusID":"14","companyTruncated":"Skye Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Nimacimab","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Skye Bioscience \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"Skye Bioscience \/ Not Applicable"}]

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                            01

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Bioscience Confirms Nimacimab Development After Monlunabant Data

                            Details : RYI-018 (nimacimab) is a negative-allosteric modulating antibody targeting the CB1. It will undergo clinical phase 2 development for the treatment of patients with obesity.

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 23, 2024

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Bioscience Launches Phase 2 Trial of Nimacimab for Obesity Treatment

                            Details : Nimacimab is a negative-allosteric modulating antibody targeting the CB1. It will undergo clinical phase 2 development for the treatment of patients with obesity.

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 22, 2024

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase I

                            Recipient : Beacon Biosignals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Beacon Biosignals Collaborates with Skye Bioscience to Integrate Sleep Quality Endpoints

                            Details : The collaboration aims to advance the clinical development of RYI-018 (nimacimab), currently being evaluated in early-stage clinical trials involving patients with obesity.

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            July 24, 2024

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase I

                            Recipient : Beacon Biosignals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase I

                            Sponsor : Beacon Biosignals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Beacon Biosignals Collaborates with Skye Bioscience to Integrate Sleep Quality Endpoints

                            Details : This partnership will incorporate sleep quality and sleep apnea endpoints via the Beacon Platform to better understand the comprehensive impact of Nimacimab on patients with obesity.

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            July 24, 2024

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase I

                            Sponsor : Beacon Biosignals

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            Skye Bioscience

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                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Concentrates Strategy and Clinical Development Focus on Nimacimab Metabolic Program

                            Details : SBI-100 is a cannabinoid receptor type 1 (“CB1”) agonist administered topically onto the eye. It is being evaluated for the treatment of primary open angle glaucoma & ocular hypertension.

                            Brand Name : SBI-100

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 10, 2024

                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Skye Bioscience

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                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Completes Enrollment for Phase 2a of SBI-100 Emulsion in Glaucoma Patients

                            Details : SBI-100 is a cannabinoid receptor type 1 (“CB1”) agonist administered topically onto the eye. It is being evaluated for the treatment of primary open angle glaucoma & ocular hypertension.

                            Brand Name : SBI-100

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 26, 2024

                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Announces Clinical Development Plan in Obesity for Differentiated Peripheral CB1 Inhibitor, Nimacimab

                            Details : Nimacimab is a negative-allosteric modulating antibody targeting the cannabinoid 1 receptor (CB1). Now it will undergo clinical development for the treatment of patients with obesity and chronic kidney disease.

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 11, 2023

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Skye Bioscience

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                            Lead Product(s) : SBI-100

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Skye Bioscience Treats First Patient in Glaucoma Phase 2 Study of SBI-100 Ophthalmic Emulsion

                            Details : SBI-100 is a cannabinoid receptor type 1 (CB1) agonist administered topically onto the eye. It is being evaluated to lower intraocular pressure and in patients with primary open-angle glaucoma or ocular hypertension.

                            Brand Name : SBI-100

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 28, 2023

                            Lead Product(s) : SBI-100

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Skye Bioscience

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                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I

                            Recipient : Bird Rock Bio

                            Deal Size : $20.0 million

                            Deal Type : Acquisition

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                            Skye Acquires Bird Rock Bio

                            Details : Through the acquisition, Skye expand its position as a leading endocannabinoid systemfocused pharmaceutical company by including, Bird Rock's lead asset, nimacimab, a first-in-class peripherally-restricted negative allosteric modulator antibody inhibitor...

                            Brand Name : RYI-018

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            August 21, 2023

                            Lead Product(s) : Nimacimab

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I

                            Recipient : Bird Rock Bio

                            Deal Size : $20.0 million

                            Deal Type : Acquisition

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                            10

                            Skye Bioscience

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                            BMWS24
                            Not Confirmed

                            Skye Bioscience

                            U.S.A arrow
                            BMWS24
                            Not Confirmed
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                            Lead Product(s) : SBI-100

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : 5AM Ventures

                            Deal Size : $17.0 million

                            Deal Type : Financing

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                            Skye Completes $17M Financing and Acquires Novel Phase 2-Ready CB1-Inhibiting Monoclonal Antibody

                            Details : The net financing will be used to advance Phase 2 of SBI-100 OE, a first-in-class, topically-administered CB1 agonist focused on reducing intraocular pressure related to glaucoma and ocular hypertension.

                            Brand Name : SBI-100

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 21, 2023

                            Lead Product(s) : SBI-100

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : 5AM Ventures

                            Deal Size : $17.0 million

                            Deal Type : Financing

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