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    [{"orgOrder":0,"company":"Eagle Pharmaceuticals","sponsor":"Enalare Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"ENA-001","moa":"Potassium channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Eagle Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Intramuscular Injection","sponsorNew":"Eagle Pharmaceuticals \/ Enalare Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Eagle Pharmaceuticals \/ Enalare Therapeutics"},{"orgOrder":0,"company":"Aexon Labs","sponsor":"NLS Pharmaceutics","pharmaFlowCategory":"D","therapeuticArea":"Sleep","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Licensing Agreement","leadProduct":"AEX-2","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"Aexon Labs","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Intraperitoneal Injection","sponsorNew":"Aexon Labs \/ NLS Pharmaceutics","highestDevelopmentStatusID":"4","companyTruncated":"Aexon Labs \/ NLS Pharmaceutics"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Aexon Labs","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"AEX-2","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Intraperitoneal Injection","sponsorNew":"NLS Pharmaceutics \/ Aexon Labs","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Aexon Labs"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Aexon Labs","pharmaFlowCategory":"D","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Undisclosed","year":"2023","type":"Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Oral","sponsorNew":"NLS Pharmaceutics \/ Aexon Labs","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Aexon Labs"},{"orgOrder":0,"company":"Bioprojet Pharma","sponsor":"Harmony Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Sleep","country":"FRANCE","productType":"Other Small Molecule","year":"2024","type":"Licensing Agreement","leadProduct":"TPM-1116","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"Bioprojet Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Bioprojet Pharma \/ Harmony Biosciences","highestDevelopmentStatusID":"4","companyTruncated":"Bioprojet Pharma \/ Harmony Biosciences"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"AEX-41","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NLS Pharmaceutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Inapplicable"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"AEX-41","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NLS Pharmaceutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Inapplicable"},{"orgOrder":0,"company":"Orexia Therapeutics","sponsor":"Centessa Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Sleep","country":"U.S.A","productType":"Undisclosed","year":"2021","type":"Merger","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"Orexia Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Oral","sponsorNew":"Orexia Therapeutics \/ Centessa Pharmaceuticals","highestDevelopmentStatusID":"4","companyTruncated":"Orexia Therapeutics \/ Centessa Pharmaceuticals"},{"orgOrder":0,"company":"NLS Pharmaceutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Controlled Substance","year":"2024","type":"Inapplicable","leadProduct":"Mazindol","moa":"MAO transporter","graph1":"Sleep","graph2":"Preclinical","graph3":"NLS Pharmaceutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NLS Pharmaceutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"NLS Pharmaceutics \/ Inapplicable"},{"orgOrder":0,"company":"F. Hoffmann-La Roche","sponsor":"PsychoGenics","pharmaFlowCategory":"D","therapeuticArea":"Sleep","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2023","type":"Licensing Agreement","leadProduct":"RO7117997","moa":"Undisclosed","graph1":"Sleep","graph2":"Preclinical","graph3":"F. Hoffmann-La Roche","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"F. Hoffmann-La Roche \/ PsychoGenics","highestDevelopmentStatusID":"4","companyTruncated":"F. Hoffmann-La Roche \/ PsychoGenics"},{"orgOrder":0,"company":"Enalare Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"ENA-001","moa":"Potassium channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Enalare Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"Enalare Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Enalare Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Enalare Therapeutics","sponsor":"National Institutes of Health","pharmaFlowCategory":"DU","therapeuticArea":"Sleep","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"ENA-001","moa":"Potassium channel","graph1":"Sleep","graph2":"Preclinical","graph3":"Enalare Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Sleep","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"Enalare Therapeutics \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"Enalare Therapeutics \/ National Institutes of Health"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            NLS Pharmaceutics

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                            NLS Pharmaceutics

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                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            NLS Announces Preclinical Data for AEX-2 Dual Orexin Agonist

                            Details : AEX-2 is a potential first-in-class non-sulfonamide dual orexin receptor agonist (DOXA), which is being evaluated for narcolepsy and related neurological disorders.

                            Product Name : AEX-2

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 27, 2025

                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            NLS Pharmaceutics

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                            Lead Product(s) : AEX-41

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            NLS Reports Preclinical Data for Dual Orexin Agonists in Narcolepsy Treatment

                            Details : AEX-41 is a first-in-class non-sulfonamide DOXAs, are designed to target both OX1R/OX2R while inhibiting cathepsins, which play significant role in narcolepsy and other neurological disorders.

                            Product Name : AEX-41

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : AEX-41

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            NLS Pharmaceutics

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                            NLS Pharmaceutics

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                            Lead Product(s) : AEX-41

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            NLS Showcases Preclinical Non-Sulfonamide Dual Orexin Agonists for Narcolepsy

                            Details : AEX-41 and AEX-2, two first-in-class non-sulfonamide DOXAs, are designed to target both OX1R and OX2R to address the unmet needs in narcolepsy and related neurological disorders.

                            Product Name : AEX-41

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 18, 2024

                            Lead Product(s) : AEX-41

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Bioprojet Pharma

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                            German Wound Congress
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                            Bioprojet Pharma

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                            Lead Product(s) : TPM-1116

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Harmony Biosciences

                            Deal Size : $393.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Harmony Enters Agreement to Develop Oral Orexin-2 Agonist TPM-1116

                            Details : Through the Licensing Agreement, Bioprojet will develop, manufacture, and commercialize TPM-1116, a selective oral orexin-2 receptor agonist for narcolepsy and other sleep/wake disorders.

                            Product Name : TPM-1116

                            Product Type : Other Small Molecule

                            Upfront Cash : $25.5 million

                            November 04, 2024

                            Lead Product(s) : TPM-1116

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Harmony Biosciences

                            Deal Size : $393.0 million

                            Deal Type : Licensing Agreement

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                            05

                            NLS Pharmaceutics

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                            NLS Pharmaceutics

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                            Lead Product(s) : Mazindol

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Reports Positive KO-874 Study on Mazindol for Narcoleptic-like Model

                            Details : The Company's lead candidate, Quilience®, is a proprietary extended-release formulation of Mazindol (Mazindol ER) and is being developed for the treatment of orexin-B-saporin induced narcolepsy.

                            Product Name : Quilience

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            May 28, 2024

                            Lead Product(s) : Mazindol

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Aexon Labs

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                            German Wound Congress
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                            Aexon Labs

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                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : NLS Pharmaceutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Secures Exclusive Global License for Dual Orexin Agonist Platform

                            Details : The agreement grants NLS global rights to next-gen oral OX1R/OX2R agonists, including AEX-2, tailored for narcolepsy, idiopathic hypersomnia, Parkinson's disease, dementia with Lewy bodies.

                            Product Name : AEX-2

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 20, 2024

                            Lead Product(s) : AEX-2

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : NLS Pharmaceutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            NLS Pharmaceutics

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                            NLS Pharmaceutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            NLS Pharmaceutics Announces Exclusive Option Agreement to Develop and Commercialize Next Generation Dual Orexi...

                            Details : Under the agreement, NLS may acquire development and commercialization rights to Aexon Labs' dual orexin receptor agonists platform for the treatment of narcolepsy and idiopathic hypersomnia, as well as neuro-degenerative disorders.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            January 12, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Aexon Labs

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            08

                            F. Hoffmann-La Roche

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                            German Wound Congress
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                            F. Hoffmann-La Roche

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                            Lead Product(s) : RO7117997

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : PsychoGenics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            PsychoGenics Announces Exclusive Global License for an IND-Ready ENT1 Inhibitor for the Treatment of Neuropsyc...

                            Details : Under the agreement, Roche obtains global development, manufacturing, and commercialization rights to RO7117997, an IND-ready ENT1 inhibitor discovered using the PsychoGenics’ AI-enabled phenotypic screening platforms.

                            Product Name : RO7117997

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 12, 2023

                            Lead Product(s) : RO7117997

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : PsychoGenics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            RespireRx Pharmaceuticals

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                            German Wound Congress
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                            RespireRx Pharmaceuticals

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                            Lead Product(s) : Tetrahydrocannabinol

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            RespireRx Pharmaceuticals Inc. Announces Patent Filings Claiming Novel Lipid Based Formulations for Insoluble ...

                            Details : Provisional patent application describing novel lipid based formulation technology (LFT) that may be used to improve the solubility and bioavailability of poorly soluble drugs particularly cannabinoids Dronabinol that is formulated as a sesame oil emulsi...

                            Product Name : ResolutionRx

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            March 23, 2022

                            Lead Product(s) : Tetrahydrocannabinol

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Eagle Pharmaceuticals

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                            German Wound Congress
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                            Eagle Pharmaceuticals

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                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Study Phase : Preclinical

                            Sponsor : Enalare Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Eagle Pharmaceuticals and Enalare Therapeutics Announce FDA Orphan Drug Designation for ENA-001 for the Treatm...

                            Details : ENA-001, is a one-of-a-kind new chemical entity (NCE) designed as an agnostic respiratory stimulant. The compound has a novel mechanism of action that affects ventilation via the peripheral chemoreceptor pathways in the carotid body.

                            Product Name : ENA-001

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 10, 2022

                            Lead Product(s) : ENA-001

                            Therapeutic Area : Sleep

                            Highest Development Status : Preclinical

                            Sponsor : Enalare Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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