[{"orgOrder":0,"company":"Pyxis Oncology","sponsor":"Decheng Capital","pharmaFlowCategory":"D","amount":"$123.0 million","upfrontCash":"Undisclosed","newsHeadline":"Apexigen Completes $123 Million Series C Financing To Advance Clinical Pipeline","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"Pyxis Oncology","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Apexigen's APX005M Granted Orphan Drug Designations for the Treatment of Esophageal and Gastroesophageal Junction Cancer and for the Treatment of Pancreatic Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"October 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Find Clinical Drug Pipeline Developments & Deals for Sotigalimab
Through the acquisition, Pyxis Oncology positions at forefront of Antibody-Drug Conjugate (ADC) development by adding PYX-107 (sotigalimab), a potential best-in-class Phase 2 CD40 agonist in clinical development for liposarcoma, melanoma, and other cancers.
Through the acquisition, Pyxis Oncology positions at forefront of Antibody-Drug Conjugate (ADC) development by adding APX 005 (sotigalimab), a potential best-in-class Phase 2 CD40 agonist in clinical development for liposarcoma, melanoma, and other cancers.
The gross proceeds will be used to finance and further support the company’s ongoing Phase 2 clinical study evaluating its CD40 antibody, APX005M (sotigalimab), in combination with doxorubicin in patients with liposarcoma.
Sotiga (sotigalimab) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses leading tumor-specific immune activation.
APX005M (sotigalimab) is a CD40 agonist that has been designed to reverse the systemic immune suppression that typically affects cancer patients, through the activation of several mechanisms of immune functionality.
The combination of intratumoral sotigalimab and systemic pembrolizumab was well-tolerated and demonstrated an improved clinical response rate relative to the standard of care, pembrolizumab monotherapy.
Sotiga (sotigalimab) in combination with neoadjuvant chemoradiation induced higher pathologic complete response rates, an important predictor of survival, in patients with both adenocarcinoma and squamous cell carcinoma.
Sotigalimab (sotiga), Apexigen’s agonist antibody targeting CD40, in combination with neoadjuvant chemoradiation for patients with resectable esophageal and gastroesophageal junction (GEJ) cancers.
APX005M (Sotigalimab) is a potent CD40 agonist that has been designed to reverse the systemic immune suppression that typically affects cancer patients, through the activation of several mechanisms of immune functionality.
Intratumoral CD40 agonist APX005M (sotigalimab) with pembrolizumab induces broad innate and adaptive immune activation in local and distant tumors in metastatic melanoma.