[{"orgOrder":0,"company":"Spectral Medical","sponsor":"Dialco Medical","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Peptide","year":"2022","type":"Not Applicable","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Spectral Medical \/ Dialco Medical","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Dialco Medical"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Paradigm Capital","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2023","type":"Private Placement","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Spectral Medical \/ Paradigm Capital","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Paradigm Capital"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Spectral Medical \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Not Applicable"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Baxter Healthcare Corporation","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2024","type":"Agreement","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Spectral Medical \/ Baxter Healthcare Corporation","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Baxter Healthcare Corporation"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Spectral Medical \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Not Applicable"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Paradigm Capital","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2024","type":"Financing","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0.01,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.01,"dosageForm":"","sponsorNew":"Spectral Medical \/ Paradigm Capital","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Paradigm Capital"},{"orgOrder":0,"company":"Spectral Medical","sponsor":"Paradigm Capital","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2024","type":"Financing","leadProduct":"Polymyxin B Sulfate","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Approved","graph3":"Spectral Medical","amount2":0.01,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.01,"dosageForm":"","sponsorNew":"Spectral Medical \/ Paradigm Capital","highestDevelopmentStatusID":"12","companyTruncated":"Spectral Medical \/ Paradigm Capital"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The net proceeds from the offering are expected to be primarily used by the company on its late-stage product Toraymyxin (Polymyxin B) for its PMX treatment for endotoxemic septic shock.

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 30, 2024

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Paradigm Capital

                          Deal Size : $8.5 million

                          Deal Type : Financing

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                          02

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The proceeds will primarily support Phase III trial for PMX treatment of endotoxemic septic shock, evaluating Toraymyxin (polymyxin B), a therapeutic hemoperfusion device that removes endotoxin.

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 09, 2024

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Paradigm Capital

                          Deal Size : $6.2 million

                          Deal Type : Financing

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                          03

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : Toraymyxin (Polymyxin B) is a small molecule drug candidate which is shown to inhibit bacterial respiration. It is being evaluated for the treatment of septic shock.

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 10, 2024

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : Baxter holds exclusive rights to commercialize Toraymyxin (polymyxin B), a therapeutic device removing endotoxins from the bloodstream, guided by Spectral’s Endotoxin Activity Assay.

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : $5.0 million

                          February 21, 2024

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Baxter Healthcare Corporation

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          05

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : PMX (Toraymyxin™ PMX-20R) is a polymyxin B extracorporeal direct hemoperfusion adsorption column which is highly effective in removing endotoxin which can cause sepsis, from the bloodstream.

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 14, 2023

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : The net proceeds are expected to be primarily used by the Company on its Phase III registration trial (Tigris) for its unique product for the treatment of patients with septic shock, Toraymyxin (polymyxin B), a therapeutic hemoperfusion device that remov...

                          Brand Name : Toraymyxin

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 10, 2023

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Paradigm Capital

                          Deal Size : $3.7 million

                          Deal Type : Private Placement

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                          07

                          BioFlorida Conference
                          Not Confirmed
                          BioFlorida Conference
                          Not Confirmed

                          Details : Toraymyxin PMX 20R, is a Polymyxin B extracorporeal direct hemoperfusion adsorption column which is highly effective in removing endotoxin in the bloodstream.

                          Brand Name : Toraymyxin PMX 20R

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          July 20, 2022

                          Lead Product(s) : Polymyxin B Sulfate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Dialco Medical

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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