Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Basilea Pharmaceutica
Deal Size : $2.3 million
Deal Type : Acquisition
Basilea Announces Acquisition of Preclinical Antibiotics Program from Spexis
Details : Through the acquisition, Basilea gains a preclinical program of antibiotics from a novel class, targeting Gram-negative bacteria, including multidrug-resistant strains.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
January 15, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Basilea Pharmaceutica
Deal Size : $2.3 million
Deal Type : Acquisition
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : SPRIM Global Investments
Deal Size : $2.5 million
Deal Type : Financing
Details : The financing will be used to fund the upcoming Phase 3 studies of ColiFin (colistimethate sodium), an inhaled antibiotic therapeutic for the management of chronic infections in cystic fibrosis patients.
Brand Name : ColiFin
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 15, 2023
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : SPRIM Global Investments
Deal Size : $2.5 million
Deal Type : Financing
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : SPRIM Global Investments
Deal Size : Undisclosed
Deal Type : Financing
Details : The net proceeds from the capital commitment will enable the initiation of the Phase 3 COPILOT study, the first part of the registrational clinical studies planned for ColiFin, an inhaled therapeutic for the management of chronic infections in cystic fib...
Brand Name : ColiFin
Molecule Type : Peptide
Upfront Cash : Undisclosed
April 18, 2023
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : SPRIM Global Investments
Deal Size : Undisclosed
Deal Type : Financing
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : SPRIM Global Investments
Deal Size : Undisclosed
Deal Type : Partnership
Details : This collaboration is expected to provide capitalization through significant clinical milestones in ColiFin®’s Phase 3 development. ColiFin® (colistimethate sodium) is being developed for the treatment of chronic lung infections in cystic fibrosis (C...
Brand Name : ColiFin
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 08, 2023
Lead Product(s) : Colistimethate Sodium
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : SPRIM Global Investments
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Murepavadin
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Inhaled Murepavadin is an antibiotic targeting pseudomonas aeruginosa in cystic fibrosis, non-CF bronchiectasis. It binds to LptD and inhibits lipopolysaccharide transport function of LptD and causes lipopolysaccharide alterations in the bacterium and ul...
Brand Name : Undisclosed
Molecule Type : Peptide
Upfront Cash : Not Applicable
January 09, 2023
Lead Product(s) : Murepavadin
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Balixafortide,Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Balixafortide (POL6326), is a potent, specific and highly selective macrocycle inhibitor of CXCR4 that plays a role in a number of tumor types as well as non-oncology indications.
Brand Name : POL6326
Molecule Type : Peptide
Upfront Cash : Not Applicable
December 13, 2022
Lead Product(s) : Balixafortide,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Balixafortide
Therapeutic Area : Nephrology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Spexis Announces Positive Renal Impairment Clinical Trial Results With Balixafortide
Details : In this trial, POL6326 (balixafortide) was shown to be safe and well tolerated in all subjects, with only transient and mild-to-moderate manageable hypersensitivity-like events known to occur during initial drug infusion with CXCR4 inhibitors.
Brand Name : POL6326
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 22, 2022
Lead Product(s) : Balixafortide
Therapeutic Area : Nephrology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Balixafortide,Docetaxel
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : University of Michigan
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The preclinical study of metastatic prostate cancer combining POL6326 (balixafortide) and docetaxel (5 mg/kg once weekly) assessed tumor burden and tumor-induced bone degradation. Overall, results showed superior synergistic efficacy compared to either d...
Brand Name : POL6326
Molecule Type : Peptide
Upfront Cash : Not Applicable
July 07, 2022
Lead Product(s) : Balixafortide,Docetaxel
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : University of Michigan
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : POL7306
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Discovery
Sponsor : CARB-X
Deal Size : $1.9 million
Deal Type : Funding
Details : The award will support the continuation of the "thanatin derivatives program" including POL7306, belonging to Spexis' novel Outer Membrane Protein Targeting Antibiotic class of antibiotics to potentially treat life-threatening infections.
Brand Name : POL7306
Molecule Type : Peptide
Upfront Cash : Undisclosed
March 03, 2022
Lead Product(s) : POL7306
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Discovery
Sponsor : CARB-X
Deal Size : $1.9 million
Deal Type : Funding
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