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    [{"orgOrder":0,"company":"SQZ Biotechnologies","sponsor":"Temasek","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Series D Financing","leadProduct":"Atezolizumab","moa":"CD8 T-Cell","graph1":"Oncology","graph2":"Phase I","graph3":"SQZ Biotechnologies","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.070000000000000007,"dosageForm":"","sponsorNew":"SQZ Biotechnologies \/ Temasek","highestDevelopmentStatusID":"6","companyTruncated":"SQZ Biotechnologies \/ Temasek"},{"orgOrder":0,"company":"SQZ Biotechnologies","sponsor":"BofA Securities","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Public Offering","leadProduct":"Atezolizumab","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"SQZ 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Applicable"},{"orgOrder":0,"company":"SQZ Biotechnologies","sponsor":"F. Hoffmann-La Roche","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Collaboration","leadProduct":"Pembrolizumab","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"SQZ Biotechnologies","amount2":1.3799999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":1.3799999999999999,"dosageForm":"Injectable\/Injection","sponsorNew":"SQZ Biotechnologies \/ F. Hoffmann-La Roche","highestDevelopmentStatusID":"7","companyTruncated":"SQZ Biotechnologies \/ F. Hoffmann-La Roche"}]

    Find Clinical Drug Pipeline Developments & Deals by SQZ Biotechnologies

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                            01

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $1,375.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Provides Update on Collaboration with Roche

                            Details : Under the collaboration, SQZ Biotechnologies will regain full clinical development and future commercialization rights for its programs including, SQZ-eAPC-HPV, based on antigen presenting cells (APCs) created by the SQZ platform and targeting HPV 16 pos...

                            Brand Name : SQZ-eAPC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : $125.0 million

                            July 25, 2023

                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $1,375.0 million

                            Deal Type : Collaboration

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                            02

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-AAC-HPV,Ipilimumab,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Announces Confirmed Complete Response in HPV16+ Solid Tumor Patient in the Lowest-Dose Coh...

                            Details : SQZ-AAC-HPV are derived from RBCs engineered with the Cell Squeeze® technology, designed to take advantage of the natural physiological process of aged RBC clearance by resident APCs in lymphoid organs which primes endogenous T cells to potentially driv...

                            Brand Name : SQZ-AAC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 22, 2023

                            Lead Product(s) : SQZ-AAC-HPV,Ipilimumab,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Receives FDA Fast Track Designation for its eAPC Therapeutic Candidate for Treatment of HP...

                            Details : The SQZ® eAPC platform is the company’s second-generation cell therapy platform which simultaneously delivers five different mRNAs—each encoding for a different protein which plays a part in stimulating key T cell activation signals.

                            Brand Name : SQZ-eAPC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            December 06, 2022

                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Announces Strategic Prioritization of SQZ® Enhanced Antigen Presenting Cells Program; Arm...

                            Details : SQZ-eAPC-HPV are derived from PBMCs, which are primarily composed of monocytes, T cells, B cells, and NK cells, and engineered with various mRNA encoding for multiple target antigens and immuno-stimulatory signals, including CD86 and membrane-bound IL-2 ...

                            Brand Name : SQZ-eAPC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 30, 2022

                            Lead Product(s) : SQZ-eAPC-HPV,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-AAC

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Publishes Preclinical Research Demonstrating SQZ® AAC Platform’s Potential as an Effect...

                            Details : Data, published in Frontiers in Immunology, demonstrated that Cell Squeeze® SQZ-AAC platform can be used to generate AACs by engineering RBCs with antigen and adjuvant that can drive antigen-specific activation of T cells both in mouse in vivo and human...

                            Brand Name : SQZ-AAC

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 03, 2022

                            Lead Product(s) : SQZ-AAC

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-PBMC-HPV,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies and Collaborators Publish Technology Review on SQZ® APCs and Effective CD8 T Cell Activat...

                            Details : SQZ-APC-HPV (SQZ-PBMC-HPV) is company’s APC autologous cell therapy clinical candidate and is derived from peripheral blood mononuclear cells, primarily composed of monocytes, T cells, B cells, and NK cells, and engineered tumor specic E6 and E7 peptid...

                            Brand Name : SQZ-APC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 12, 2022

                            Lead Product(s) : SQZ-PBMC-HPV,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-PBMC-HPV,Nivolumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Announces First Data Presentation on Non-Clinical Studies of Point-of-Care Manufacturing S...

                            Details : SQZ-PBMC-HPV is an autologous cell therapy candidate comprised of SQZ-engineered antigen presenting cells (APCs) designed to induce CD8 T cell responses against HPV16.

                            Brand Name : SQZ-PBMC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 05, 2022

                            Lead Product(s) : SQZ-PBMC-HPV,Nivolumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            SQZ Biotechnologies

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                            Lead Product(s) : SQZ-PBMC-HPV,Atezolizumab,Ipilimumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Receives FDA Fast Track Designation for its Lead Cell Therapy Candidate for the Treatment ...

                            Details : SQZ-PBMC-HPV is being evaluated in a Phase 1/2 clinical trial for the treatment of HPV16+ advanced or metastatic solid tumors. Patients must be positive for the human leukocyte antigen serotype HLA-A*02.

                            Brand Name : SQZ-PBMC-HPV

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 27, 2022

                            Lead Product(s) : SQZ-PBMC-HPV,Atezolizumab,Ipilimumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            SQZ Biotechnologies

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                            Lead Product(s) : RBC-derived Engineered Cell Therapy

                            Therapeutic Area : Endocrinology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Publishes Comprehensive Preclinical Research on SQZ® TAC Platform’s Ability to Induce M...

                            Details : The data published, demonstrated that TACs can induce multiple key mechanisms of antigen-specific tolerance in various model systems, including deletion of autoreactive T cells, energy, and expansion of regulatory T cells capable of bystander suppression...

                            Brand Name : SQZ TACs

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 04, 2022

                            Lead Product(s) : RBC-derived Engineered Cell Therapy

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            SQZ Biotechnologies

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                            Lead Product(s) : Allogeneic Cell Replacement Therapy

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : $2.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            SQZ Biotechnologies Announces $2 Million Grant From the National Institutes of Health to Develop a Novel, Scal...

                            Details : With the support of the NIH grant, and building upon our experience in multiplex engineering of immune cells, SQZ researchers will attempt to generate dopaminergic neurons directly from somatic cells.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 21, 2022

                            Lead Product(s) : Allogeneic Cell Replacement Therapy

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : $2.0 million

                            Deal Type : Funding

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