Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
STORM Therapeutics to Present First-in-Class METTL1 Inhibitors at ESMO Congress
Details : METTL1 inhibits tumour growth and reduces tRNA methylation and stability of tRNAs. It displayed high selectivity over other RNA and protein methyltransferases.
Product Name : Undisclosed
Product Type : Small molecule
Upfront Cash : Not Applicable
February 22, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : STC-15
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. STC-15, also inhibits tumor growth through mechanisms like changes in interferon signaling and synergy with T cell checkpoint block...
Product Name : STC-15
Product Type : Small molecule
Upfront Cash : Not Applicable
January 25, 2023
Lead Product(s) : STC-15
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : An orally bioavailable, highly selective METTL3 inhibitor, STC-15 is the first molecule specifically targeting an RNA methyltransferase enzyme to enter clinical development.
Product Name : STC-15
Product Type : Small molecule
Upfront Cash : Not Applicable
November 23, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Discovery Platform
Sponsor : Innovate Biopharmaceuticals
Deal Size : Undisclosed
Deal Type : Funding
Details : The Innovate UK grant will allow STORM to develop a drug acting on a key coronavirus protein that is not targeted by current treatments. Generation of such a drug will provide a valuable option for treating Covid-19 and other coronavirus diseases.
Product Name : Undisclosed
Product Type : Small molecule
Upfront Cash : Undisclosed
May 03, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Discovery Platform
Sponsor : Innovate Biopharmaceuticals
Deal Size : Undisclosed
Deal Type : Funding
Details : The collaboration will focus initially on ADAR1, advancing early work by STORM applying its proprietary RNA epigenetic platform, as well as explore an additional undisclosed target.
Product Name : Undisclosed
Product Type : Small molecule
Upfront Cash : $17.0 million
October 14, 2021
Lead Product(s) : STM2457
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : STORM has identified novel, potent and selective first-in-class inhibitors of METTL3 that are orally bioavailable and show pronounced anti-tumour efficacy in animal models of AML, as well as solid tumours. This publication utilises STM2457, an earlier co...
Product Name : STM2457
Product Type : Small molecule
Upfront Cash : Not Applicable
April 26, 2021
Lead Product(s) : STM2457
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : STC-15
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
STORM Therapeutics Selects First-in-Class Clinical Candidate Targeting METTL3
Details : STC-15 is an orally bioavailable, small molecule METTL3 inhibitor targeting an entirely new mechanism of action (modulation of RNA epigenetics) to treat acute myeloid leukaemia (AML) and other solid and haematological cancers.
Product Name : STC-15
Product Type : Small molecule
Upfront Cash : Not Applicable
October 22, 2020
Lead Product(s) : STC-15
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable