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    [{"orgOrder":0,"company":"Therapeutic Solutions","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2020","type":"Collaboration","leadProduct":"Pterostilbene","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Undisclosed","graph3":"Therapeutic Solutions","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Therapeutic Solutions \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"Therapeutic Solutions \/ Undisclosed"},{"orgOrder":0,"company":"Therapeutic Solutions","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Pterostilbene","moa":"NLRP3","graph1":"Oncology","graph2":"Preclinical","graph3":"Therapeutic 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Diseases","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Pterostilbene","moa":"NLRP3","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Therapeutic Solutions","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Therapeutic Solutions \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Therapeutic Solutions \/ Not Applicable"},{"orgOrder":0,"company":"Evgen Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Sulforaphane","moa":"SHP2 pathway","graph1":"Oncology","graph2":"Preclinical","graph3":"Evgen Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Evgen Pharma \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Evgen Pharma \/ Not Applicable"}]

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                            01

                            Evgen Pharma

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                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Publication Of Data On SFX-01 In Glioblastoma

                            Details : The in vitro data, in GBM cells and patient-derived glioma-initiating cells, show anti-tumour activity of the Company's lead asset SFX-01. In both models, SFX-01 reduced tumour growth substantially and demonstrated statistically significant improved surv...

                            Brand Name : SFX-01

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 10, 2021

                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Therapeutic Solutions

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                            Therapeutic Solutions

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                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Therapeutic Solutions International Discovers and Files Patent on Novel Cellular Therapy Combination for Augme...

                            Details : JadiCells, as well as QuadraMune®, a commercially available nutraceutical developed by the Company have been shown to reduce lung scarring in other experiments.

                            Brand Name : QuadraMune

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 22, 2021

                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Evgen Pharma

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                            Lead Product(s) : Sulforaphane,Alpha-Cyclodextrin

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $15.3 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Evgen Pharma Announces Placing and Open Offer to raise up to £11 million

                            Details : The net proceeds of the Fundraising are intended to be used to complete the formulation and scale up manufacturing of SFX-01 and other R&D nd general corporate purposes.

                            Brand Name : SFX-01

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            February 02, 2021

                            Lead Product(s) : Sulforaphane,Alpha-Cyclodextrin

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $15.3 million

                            Deal Type : Public Offering

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                            04

                            Evgen Pharma

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                            Evgen Pharma

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                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Evgen Pharma Announces Positive Pre-Clinical Data in Glioma for Lead Asset SFX-01

                            Details : The data generated for SFX-01 in standard pre-clinical models and orthotopic models (where glioma cells are implanted in brain tissue representing a more disease-relevant model) show tumour shrinkage and significantly extended survival times.

                            Brand Name : SFX-01

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 21, 2021

                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Evgen Pharma

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                            Evgen Pharma

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                            Lead Product(s) : Sulforaphane,Alpha-Cyclodextrin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : University of Dundee

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Evgen Pharma Provides Patient Recruitment Update in STAR-COVID 19 Trial

                            Details : A total of 56 patients had been recruited and randomised to the STAR trial ("SFX-01 treatment for Acute Respiratory Infections").SFX-01 upregulates the Nrf2 pathway which is part of the natural human defence against inflammatory and oxidative stress.

                            Brand Name : SFX-01

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 19, 2021

                            Lead Product(s) : Sulforaphane,Alpha-Cyclodextrin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : University of Dundee

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Therapeutic Solutions

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                            Therapeutic Solutions

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                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            QuadraMune™ Synergizes with Metformin to Stimulate Anti-Viral Defenses in Pilot Clinical Trial

                            Details : Using a standard test for natural killer cell activity, the K562 lysis assay, 12 healthy volunteers taking one week of placebo had an average activity of 2.3 (±0.6), whereas those taking one week of QuadraMune™ had an average activity of 5.2 (±1.2), ...

                            Brand Name : QuadraMune

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 24, 2020

                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Evgen Pharma

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                            Evgen Pharma

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                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Evgen Pharma Recruits First Patient in STAR Trial

                            Details : This Phase II/III trial will investigate whether the Company's lead asset, SFX-01, can reduce the severity, or prevent the onset of, acute respiratory distress syndrome in patients with community-acquired pneumonia who have been or are being tested for s...

                            Brand Name : SFX-01

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 23, 2020

                            Lead Product(s) : Sulforaphane

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Therapeutic Solutions

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                            Therapeutic Solutions

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                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Therapeutic Solutions International Reports Synergistic Suppression of Suicide-Associated Neuroinflammatory Pa...

                            Details : QuadraMune™ is a nutraceutical developed by the Company which is currently in a clinical trial for prevention of COVID-19[1]. Minocycline is an antibiotic that is approved by the FDA.

                            Brand Name : QuadraMune

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 28, 2020

                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Therapeutic Solutions

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                            Therapeutic Solutions

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                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Therapeutic Solutions International Reports Reduction of Inflammation Associated Memory Impairment by QuadraMu...

                            Details : Pterostilbene is one of four ingredients which comprise QuadraMune™, a nutraceutical being developed by the Company which is currently in a clinical trial for prevention of COVID-19.

                            Brand Name : QuadraMune

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 28, 2020

                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Therapeutic Solutions

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                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Therapeutic Solutions International Reports QuadraMune Reduces Myeloid Suppressor Cells in 4T1 Mouse Model of ...

                            Details : In a series of animal studies using the triple-negative breast cancer 4T1 mouse model, the Company showed that administration of QuadraMune™ reduced lung metastasis on its own and increased efficacy of a “cancer vaccine.

                            Brand Name : QuadraMune

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 11, 2020

                            Lead Product(s) : Pterostilbene,Green Tea Extract,Sulforaphane

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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