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    [{"orgOrder":0,"company":"Summit Therapeutics","sponsor":"Biomedical Advanced Research and Development Authority","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"UNITED KINGDOM","productType":"Small molecule","year":"2020","type":"Funding","leadProduct":"Ridinilazole","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Summit Therapeutics","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.070000000000000007,"dosageForm":"Oral","sponsorNew":"Summit Therapeutics \/ Biomedical Advanced Research and Development Authority","highestDevelopmentStatusID":"10","companyTruncated":"Summit Therapeutics \/ Biomedical Advanced Research and Development Authority"},{"orgOrder":0,"company":"Summit Therapeutics","sponsor":"Eurofarma Laboratorios S.A","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious 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Therapeutics","amount2":0.23999999999999999,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Summit Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"14","companyTruncated":"Summit Therapeutics \/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals by Summit Therapeutics

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                            01

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Pemetrexed,Carboplatin

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $235.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Summit Therapeutics Raises $235 Million

                            Details : Summit intends to use the net proceeds to advance, in part, the clinical development of SMT112 (ivonescimab) for the treatment of EFGR-mutated non-small cell lung cancer.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 12, 2024

                            Lead Product(s) : Ivonescimab,Pemetrexed,Carboplatin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $235.0 million

                            Deal Type : Private Placement

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                            02

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : University of Texas MD Anderson

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Summit Therapeutics and MD Anderson Collaborate to Accelerate Ivonescimab Development

                            Details : The collaboration aims to advance the clinical development of the company-lead product that targets PD-1/VEGF, SMT112 (ivonescimab) for treating patients with PD-L1-positive solid tumors.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            July 25, 2024

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : University of Texas MD Anderson

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $200.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Summit Raises $200 Million; Also Expands License Territories for Ivonescimab

                            Details : Summit will to advance the clinical development of SMT112 (ivonescimab), a novel, potential first-in-class investigational bispecific antibody, in non-small cell lung cancer (NSCLC).

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            June 03, 2024

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $200.0 million

                            Deal Type : Financing

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                            04

                            Summit Therapeutics

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                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Pemetrexed,Carboplatin

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ivonescimab Approved in China for EGFRm NSCLC Based on HARMONi-A Trial

                            Details : Ivonescimab, known as AK112 in China and Australia, is a novel, first-in-class, approved bispecific antibody blocking PD-1 with VEGF for treating EGFR-mutated, advanced non-squamous NSCLC.

                            Brand Name : AK112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 31, 2024

                            Lead Product(s) : Ivonescimab,Pemetrexed,Carboplatin

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Summit Therapeutics

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                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Ivonescimab Shows Superiority Over Pembrolizumab in NSCLC First-Line Treatment

                            Details : Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody inhibiting PD-1 with VEGF is being investiated for PD-L1-positive NSCLC.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 30, 2024

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Akeso

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Akeso Announced Completion of Patient Enrollment in Phase 3 Trial of Ivonescimab (PD-1/VEGF) versus Pembrolizu...

                            Details : SMT112 (ivonescimab) is a potential first-in-class investigational PD-1/VEGF bi-specific antibody, which is investigated for the treatment of first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 29, 2023

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Akeso

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Summit Therapeutics

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                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Akeso

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Akeso Announced First Patient Dosed in Phase 3 Trial of Ivonescimab versus Tislelizumab for First-line Treatme...

                            Details : SMT112 (Ivonescimab) is a potential first-in-class investigational PD-1/VEGF bi-specific antibody, which is investigated for the treatment of first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 18, 2023

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Akeso

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Summit Therapeutics Announces First Patient Treated in Phase III HARMONi Clinical Trial Evaluating Ivonescimab...

                            Details : SMT112 (ivonescimab) is an investigational bispecific antibody which blocks PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. It is being investigated for EGFR mutated NSCLC.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 09, 2023

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Summit Therapeutics

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                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Summit Therapeutics Announces Initial Indications for Clinical Trials for Ivonescimab (SMT112)

                            Details : SMT112 (ivonescimab) is a novel, potential first-in-class, investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule.

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 03, 2023

                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

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                            Summit Therapeutics Closes Fully-Subscribed $500 Million Rights Offering

                            Details : The net proceeds will be used to support the development of SMT112. Ivonescimab is a first-in-class PD-1/VEGF bispecific antibody. Engineered with Tetrabody technology, ivonescimab blocks PD-1 binding to PD-L1 and PD-L2, and blocks VEGF binding to VEGF r...

                            Brand Name : SMT112

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 03, 2023

                            Lead Product(s) : Ivonescimab,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $500.0 million

                            Deal Type : Public Offering

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