Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cogent Completes Enrollment in Phase 3 PEAK Trial for Gastrointestinal Stromal Tumors
Details : CGT9486 (bezuclastinib), is a KIT mutant inhibitor, being investigated in combination with sunitinib for patients living with gastrointestinal stromal tumors.
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 03, 2024
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : J.P. Morgan
Deal Size : $225.0 million
Deal Type : Private Placement
Cogent Biosciences Announces Oversubscribed $225 Million Private Placement
Details : The net proceeds will be used for the clinical development of CGT9486 (bezuclastinib), which is a KIT mutant inhibitor for systemic mastocytosis and gastrointestinal stromal tumors.
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 14, 2024
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : J.P. Morgan
Deal Size : $225.0 million
Deal Type : Private Placement
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : J.P. Morgan
Deal Size : $150.0 million
Deal Type : Public Offering
Cogent Biosciences Announces Pricing of Upsized Public Offering of Shares of Common Stock
Details : Cogent intends to fund the development, regulatory and commercial preparation activities relating to CGT9486 (bezuclastinib), a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in ...
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 06, 2023
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : J.P. Morgan
Deal Size : $150.0 million
Deal Type : Public Offering
Lead Product(s) : Cabozantinib,Nivolumab,Sunitinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Cabometyx (cabozantinib) is a multiple receptor tyrosine kinases inhibitor. These receptors are involved in both normal cellular function and pathologic processes such as oncogenesis, metastasis, tumor angiogenesis, maintenance of the tumor microenvironm...
Brand Name : Cabometyx
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 13, 2023
Lead Product(s) : Cabozantinib,Nivolumab,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Jefferies
Deal Size : $172.6 million
Deal Type : Public Offering
Details : The net proceeds from the offering will be used for development, regulatory and commercial preparation activities relating to CGT9486 (bezuclastinib) and other product candidates, as well as for working capital and general corporate purposes.
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 16, 2022
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Jefferies
Deal Size : $172.6 million
Deal Type : Public Offering
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering
Details : Cogent intends to use the net proceeds from the offering for development, regulatory and commercial preparation activities relating to CGT9486 (bezuclastinib) and other product candidates, as well as for working capital and general corporate purposes.
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 14, 2022
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering
Lead Product(s) : Cabozantinib,Nivolumab,Sunitinib
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Updated outcomes from trial evaluating combination of Cabometyx (Cabozantinib) plus atezolizumab in an expanded patient population in NSCLC demonstrate encouraging clinical activity with manageable toxicity in people previously treated with an immune che...
Brand Name : Cabometyx
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 26, 2022
Lead Product(s) : Cabozantinib,Nivolumab,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Sunitinib
Therapeutic Area : Ophthalmology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : GB-102 is a microparticle formulation of a pan-VEGF inhibitor, sunitinib, for the treatment of wet age-related macular degeneration designed for a twice-per-year intravitreal injection. GB-102 has the potential to also benefit patients with diabetic reti...
Brand Name : GB-102
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 19, 2022
Lead Product(s) : Sunitinib
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The MERECA study showed that the combination of ilixadencel with the tyrosine kinase inhibitor sunitinib was safe and associated with a positive trend for improved tumor response rate and overall survival, compared with sunitinib monotherapy (control gro...
Brand Name : Intuvax
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 28, 2022
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Cogent Biosciences Announces Upcoming Presentations at AACR Annual Meeting 2022
Details : Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL).
Brand Name : CGT9486
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 08, 2022
Lead Product(s) : Bezuclastinib,Sunitinib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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