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BioPharma Corp","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Pacritinib","moa":"JAK2\/FLT3","graph1":"Oncology","graph2":"Approved","graph3":"CTI BioPharma Corp","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"CTI BioPharma Corp \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"CTI BioPharma Corp \/ Not Applicable"},{"orgOrder":0,"company":"CTI BioPharma Corp","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Pacritinib","moa":"JAK2\/FLT3","graph1":"Oncology","graph2":"Approved","graph3":"CTI BioPharma 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Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Peptide","year":"2022","type":"Not Applicable","leadProduct":"Pegcetacoplan","moa":"Complement C3","graph1":"Nephrology","graph2":"Phase III","graph3":"Swedish Orphan Biovitrum AB","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Swedish Orphan Biovitrum AB \/ Sobi","highestDevelopmentStatusID":"10","companyTruncated":"Swedish Orphan Biovitrum AB \/ Sobi"},{"orgOrder":0,"company":"Swedish Orphan Biovitrum AB","sponsor":"Apellis Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Hematology","country":"","productType":"Peptide","year":"2022","type":"Not Applicable","leadProduct":"Pegcetacoplan","moa":"Complement C3","graph1":"Hematology","graph2":"Approved","graph3":"Swedish Orphan Biovitrum 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Find Clinical Drug Pipeline Developments & Deals by Swedish Orphan Biovitrum AB

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                          01

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : The agreement aims for the international development and distribution for the enFuse Injector, for the subcutaneous delivery of Aspaveli (pegcetacoplan), a targeted C3 therapy, for PNH.

                          Brand Name : Aspaveli

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          September 12, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved

                          Recipient : Enable Injections

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          02

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan injection) targets C3, being investigated for C3 glomerulopathy or primary immune complex membranoproliferative glomerulonephritis.

                          Brand Name : Syfovre

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          August 08, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Recipient : Apellis Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Altuvoct (efanesoctocog alfa) is a once-weekly and high-sustained factor VIII replacement therapy, approved for the treatment and prevention of bleeds and perioperative prophylaxis in haemophilia A.

                          Brand Name : Altuvoct

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 19, 2024

                          Lead Product(s) : Efanesoctocog Alfa

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Gamifant (emapalumab) is an anti-IFNγ monoclonal antibody that binds free and receptor-bound IFNγ, neutralizing its biological activity. Emapalumab is currently in Phase lll development for MAS.

                          Brand Name : Gamifant

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 24, 2024

                          Lead Product(s) : Emapalumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Aspaveli (pegcetacoplan) received an indication extension for PNH. It binds to complement protein C3 and is indicated for adults with paroxysmal nocturnal hemoglobinuria who have hemolytic anemia.

                          Brand Name : Aspaveli

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          May 08, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : BIVV001 (efanesoctocog alfa), a once-weekly Factor VIII therapy, is being evaluated for bleed prevention and perioperative prophylaxis in hemophilia A.

                          Brand Name : BIVV001

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 26, 2024

                          Lead Product(s) : Efanesoctocog Alfa

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : DOPTELET® (avatrombopag maleate), an oral thrombopoietin receptor agonist, which is indicated for the of thrombocytopenia and for the treatment of severe thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo an...

                          Brand Name : Doptelet

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 06, 2023

                          Lead Product(s) : Avatrombopag Maleate

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Sobi will transition the manufacturing and development rights of ImmTOR for SEL-212 to Sobi. SEL-212, a combination of Selecta’s ImmTOR immune tolerance platform and a therapeutic uricase enzyme (pegadricase), is in development for chronic refractory g...

                          Brand Name : SEL-212

                          Molecule Type : Large molecule

                          Upfront Cash : $75.0 million

                          October 31, 2023

                          Lead Product(s) : Pegadricase,ImmTOR

                          Therapeutic Area : Rheumatology

                          Highest Development Status : Phase III

                          Recipient : Selecta Biosciences

                          Deal Size : $705.0 million

                          Deal Type : Licensing Agreement

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                          09

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : The acquisition strengthens Sobi’s leading haematology franchise by adding Vonjo (pacritinib), a novel oral kinase inhibitor that inhibits JAK2, IRAK1 and ACRV1, while sparing JAK1, for the treatment of adults with myelofibrosis. Vonjo obtained acceler...

                          Brand Name : Vonjo

                          Molecule Type : Small molecule

                          Upfront Cash : $1,700.0 million

                          June 26, 2023

                          Lead Product(s) : Pacritinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : CTI BioPharma Corp

                          Deal Size : $1,700.0 million

                          Deal Type : Acquisition

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                          10

                          Pharma Manufacturing 2024
                          Not Confirmed
                          Pharma Manufacturing 2024
                          Not Confirmed

                          Details : Syfovre™ (pegcetacoplan injection) is the first and only approved therapy for geographic atrophy (GA). It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Brand Name : Syfovre

                          Molecule Type : Peptide

                          Upfront Cash : Not Applicable

                          May 25, 2023

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Recipient : Apellis Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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