Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Synlogic Announces Decision to Discontinue Synpheny-3 Study and Provides Corporate Update
Details : SYNB1934 (labafenogene marselecobac) is an orally administered, non-systemically absorbed, PheP & mPAL stimulant. It is being developed for the treatment of phenylketonuria.
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
August 02, 2024
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SYNB1934 is an orally administered, non-systemically absorbed drug candidate being studied as potential biotherapeutic for the treatment of phenylketonuria (PKU), receives Fast Track Designation from FDA.
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
November 07, 2023
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Science 37 Holdings
Deal Size : Undisclosed
Deal Type : Partnership
Details : Science 37 will provide virtual clinical trial technology and services for Synpheny-3, Synlogic's ongoing pivotal, Phase III trial of investigational drug SYNB1934 (labafenogene marselecobac) as a potential treatment for phenylketonuria, a rare, genetic ...
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
November 07, 2023
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Science 37 Holdings
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Synlogic Receives Orphan Drug Designation from FDA for SYNB1934 for Treatment of Phenylketonuria
Details : SYNB1934 is an orally administered, non-systemically absorbed drug candidate being studied as potential biotherapeutic for the treatment of phenylketonuria (PKU), receives orphan drug designation from FDA.
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
September 05, 2023
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : SYNB2081
Therapeutic Area : Rheumatology
Study Phase : IND Enabling
Sponsor : Ginkgo Bioworks
Deal Size : Inapplicable
Deal Type : Inapplicable
Synlogic Announces Synthetic Biotic for Gout Developed in Partnership with Ginkgo Bioworks
Details : The new candidate, SYNB2081, is a Synthetic Biotic and is the second product to advance to clinical development through a research collaboration between Synlogic and Ginkgo, following investigational new drug candidate SYNB1353 for the potential treatmen...
Product Name : SYNB2081
Product Type : Probiotic
Upfront Cash : Inapplicable
November 08, 2022
Lead Product(s) : SYNB2081
Therapeutic Area : Rheumatology
Highest Development Status : IND Enabling
Sponsor : Ginkgo Bioworks
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : SYNB1353
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Synlogic Granted FDA Fast Track Designation for SYNB1353 for the Treatment of Homocystinuria (HCU)
Details : SYNB1353 is a novel orally-administered, non-systemically absorbed drug candidate designed to consume methionine in the gastrointestinal tract thereby lowering homocysteine levels in patients with homocystinuria (HCU).
Product Name : SYNB1353
Product Type : Probiotic
Upfront Cash : Inapplicable
August 23, 2022
Lead Product(s) : SYNB1353
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : SYNB1618
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Synlogic Outlines Upcoming Clinical Milestones
Details : The company announced Progression of a proof of concept Phase 2 clinical trial of SYNB1618 for the treatment of Phenylketonuria (PKU). A solid oral formulation of SYNB1618 has been shown to metabolize Phe in the GI tract in a healthy volunteer study.
Product Name : SYNB1618
Product Type : Antibody
Upfront Cash : Inapplicable
November 01, 2021
Lead Product(s) : SYNB1618
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Preclinical in vivo and in vitro studies demonstrated a greater than 2-fold improvement in the ability of SYNB1934 to consume and break down Phe compared to SYNB1618, based on production of Phe metabolites.
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
July 15, 2021
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data from preclinical in vivo and in vitro studies demonstrated a greater than 2-fold improvement in the ability of SYNB1934 to metabolize Phe compared to SYNB1618.
Product Name : SYNB1934
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
June 15, 2021
Lead Product(s) : Labafenogene Marselecobac
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : SYNB8802
Therapeutic Area : Gastroenterology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SYNB8802 is moving into human clinical studies where it will be assessed for safety and tolerability, strain kinetics, changes in plasma and urine biomarkers of strain activity, and the potential to reduce urinary oxalate.
Product Name : SYNB8802
Product Type : Probiotic
Upfront Cash : Inapplicable
October 22, 2020
Lead Product(s) : SYNB8802
Therapeutic Area : Gastroenterology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable