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Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"AnHeart Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Series A Financing","leadProduct":"Taletrectinib","moa":"ROS1","graph1":"Oncology","graph2":"Phase II","graph3":"AnHeart Therapeutics","amount2":0.02,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"","sponsorNew":"AnHeart Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"AnHeart Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"AnHeart Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Taletrectinib","moa":"ROS1","graph1":"Oncology","graph2":"Phase II","graph3":"AnHeart Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics \/ Nuvation Bio"},{"orgOrder":0,"company":"Nuvation Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Taletrectinib","moa":"","graph1":null,"graph2":null,"graph3":"Nuvation Bio","amount2":0,"highestDevelopmentShortName":null,"therapeuticAreaShortName":null,"amount2New":0,"dosageForm":"","sponsorNew":"Nuvation Bio \/ Not Applicable","highestDevelopmentStatusID":null,"companyTruncated":"Nuvation Bio \/ Not Applicable"}]

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                          01

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : AB-106 (taletrectinib) is a next-generation ROS1 TKI, which is being evaluated for the treatment of adult patients with locally advanced or metastatic NSCLC.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 14, 2024

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : The acquisition adds AnHeart’s AB-106, a next-generation ROS1 inhibitor with Breakthrough Therapy Designations, currently completing two pivotal studies for ROS1-positive non-small cell lung cancer.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 10, 2024

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Nuvation Bio

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          03

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : The acquisition adds AnHeart’s AB-106, a next-generation ROS1 inhibitor with Breakthrough Therapy Designations, currently completing two pivotal studies for ROS1-positive non-small cell lung cancer.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 25, 2024

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Nuvation Bio

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          04

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : AB-106 (taletrectinib) is a next-generation ROS1 TKI evaluated for treating adults with advanced or metastatic ROS1-positive non-small cell lung cancer.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 04, 2024

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Innovent Biologics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : AB-106 (taletrectinib) is a next-generation ROS1 tyrosine kinase inhibitor (TKI), which is under phase 2 clinical development for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC).

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 18, 2023

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Innovent Biologics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : The collaboration aims for the development and regulatory approval of Foundation Medicine’s FoundationOne®CDx and FoundationOne®Liquid CDx, as companion diagnostics for AnHeart’s investigational next-generation ROS1 inhibitor, taletrectinib, in the...

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 14, 2023

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Foundation Medicine

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Under the terms of the agreement, Nippon Kayaku will be responsible for regulatory approvals and commercialization of AB-106 (taletrectinib) for ROS1-positive NSCLC in Japan, and will have rights to further develop taletrectinib for new indications in th...

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : $40.0 million

                          October 30, 2023

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Nippon Kayaku

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          08

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : AB-106 (taletrectinib) is an oral, potent, brain penetrant, selective, next-generation potential best-in-class ROS1 inhibitor being evaluated for the treatment of ROS1-positive NSCLC.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 21, 2023

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Under the terms of the collaboration, Guardant Health and AnHeart Therapeutics will develop Guardant360® CDx and Guardant360 TissueNext™ assays as companion diagnostics for AB-106 (taletrectinib) in Advanced or Metastatic ROS1-Positive NSCLC.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 02, 2023

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : AnHeart Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          10

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : AB-106 (taletrectinib) is a novel, potential best-in-class, next-generation ROS1 inhibitor designed to effectively target ROS1 fusions with potential to treat both TKI-naïve and pre-treated patients.

                          Brand Name : AB-106

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 12, 2022

                          Lead Product(s) : Taletrectinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : NewG Lab Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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