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    [{"orgOrder":0,"company":"Syros Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Tamibarotene","moa":"RAR-alpha","graph1":"Oncology","graph2":"Phase II","graph3":"Syros Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Syros Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Syros Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Syros Pharmaceuticals","sponsor":"Oxford Finance","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Funding","leadProduct":"Azacitidine","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Syros Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Announces Topline Data from Tamibarotene Phase 3 Trial

                            Details : SY-1425 (tamibarotene) is a first-in-class selective RARα agonist, being evaluated in combination with azacitidine for higher-risk myelodysplastic syndrome with RARA gene overexpression.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 12, 2024

                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Rege Nephro

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                            Rege Nephro

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                            Lead Product(s) : Tamibarotene

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : DCI Partners

                            Deal Size : $16.7 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Rege Nephro Completes Series B Funding For Kidney Disease Therapy Trials

                            Details : The funds will be used to advance the clinical trials of RN-014 (tamibarotene), company's retinoic acid receptor (RAR) agonist treatment, in Phase 2 for Autosomal Dominant Polycystic Kidney Disease.

                            Brand Name : RN-014

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 07, 2024

                            Lead Product(s) : Tamibarotene

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : DCI Partners

                            Deal Size : $16.7 million

                            Deal Type : Series B Financing

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                            03

                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Provides Update on SELECT-AML-1 Phase 2 Clinical Trial

                            Details : Company will discontinue enrollment in clinical trial evaluating SY-1425 (tamibarotene) in combination with venetoclax and azacitidine in patients with AML and RARA gene overexpression.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 12, 2024

                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Rege Nephro

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                            Rege Nephro

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                            Lead Product(s) : Tamibarotene

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Rege Nephro Enrolls Patients For Phase II Tamibarotene ADPKD Trial

                            Details : RN-014 (tamibarotene), under development for ADPKD, is a retinoic acid receptor (RAR) agonist expected to potently inhibit cyst formation and improve renal function.

                            Brand Name : RN-014

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 28, 2024

                            Lead Product(s) : Tamibarotene

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Completes Enrollment Of 190 Patients for SELECT-MDS-1 Phase 3 Trial

                            Details : SY-1425 (tamibarotene) is a selective RARα agonist being evaluated with azacitidine for newly diagnosed HR-MDS patients with RARA gene overexpression.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 25, 2024

                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : TD Cowen

                            Deal Size : $45.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Syros Announces Pricing of $45.0 million Underwritten Offering of Common Stock and Pre-Funded Warrants

                            Details : The net proceeds will be used to fund the ongoing clinical development of SY-1425 (tamibarotene), a first-in-class selective retinoic acid receptor alpha (RARα) agonist, being developed for myelodysplastic syndromes.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 19, 2023

                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : TD Cowen

                            Deal Size : $45.0 million

                            Deal Type : Public Offering

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                            07

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Announces Encouraging Initial Data from Randomized SELECT-AML-1 Phase 2 Clinical Trial Evaluating Tamiba...

                            Details : SELECT-AML-1 is evaluating the safety and efficacy of SY-1425 (tamibarotene) in combination with venetoclax and azacitidine compared to venetoclax and azacitidine in patients patients with acute myeloid leukemia and RARA gene overexpression.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 06, 2023

                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Receives Fast Track Designation from the FDA for Tamibarotene for the Treatment of Higher-Risk Myelodysp...

                            Details : SY-1425 (tamibarotene), an oral first-inclass selective retinoic acid receptor alpha (RARα) agonist, is currently being evaluated in combination with azacitidine for the treatment of newly diagnosed HR-MDS patients with RARA gene overexpression.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 26, 2023

                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Syros Pharmaceuticals

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                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Pharmaceuticals Announces Publication in Blood Advances Demonstrating the Potential of Tamibarotene in P...

                            Details : The rates of myelosuppression were comparable to SY-1425 (azacitidine) monotherapy in this population suggesting no added hematologic toxicity from tamibarotene when used in combination with azacitidine. The majority of non-hematologic adverse events (AE...

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 12, 2022

                            Lead Product(s) : Tamibarotene,Azacitidine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Syros Pharmaceuticals

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                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Syros Presents Safety Lead-in Data from SELECT-AML-1 Trial Evaluating Tamibarotene in Combination with Venetoc...

                            Details : SY-1425, having tamibarotene in combination with venetoclax and azacitidine administered at approved doses showed no evidence of increased toxicity relative to the doublet combination of venetoclax and azacitidine.

                            Brand Name : SY-1425

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 10, 2022

                            Lead Product(s) : Tamibarotene,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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