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    [{"orgOrder":0,"company":"Spero Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Tebipenem Pivoxil Hydrobromide","moa":"Cell wall","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Spero Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Film Coated Tablet","sponsorNew":"Spero Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Spero Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Spero Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Tebipenem Pivoxil Hydrobromide","moa":"Cell 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Therapeutics \/ Not Applicable"}]

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    Tebipenem Pivoxil Hydrobromide

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                            01

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Announces First Patient Visit in Phase 3 PIVOT-PO Trial of Tebipenem H Br

                            Details : SPR994 (tebipenem pivoxil hydrobromide) is an oral antibiotic in phase 3 trials for treating complicated urinary tract infections, including acute pyelonephritis.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 02, 2024

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Therapeutics Announces Special Protocol Assessment Agreement with FDA for Phase 3 PIVOT-PO Trial of Tebi...

                            Details : SPR994 is Spero’s novel late-stage development asset, an oral formulation tablet of tebipenem pivoxil hydrobromide, a carbapenem antibiotic of the β-lactam class.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 31, 2023

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : GSK

                            Deal Size : $591.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Spero Therapeutics Announces Closing of Exclusive License Agreement with GSK for Tebipenem HBr

                            Details : Under the terms of the agreement, Spero is responsible for the execution and costs of Phase 3 trial of tebipenem HBr (tebipenem pivoxil hydrobromide), an investigational drug, is being developed as the potentially first oral carbapenem antibiotic for the...

                            Brand Name : Tebipenem HBr

                            Molecule Type : Small molecule

                            Upfront Cash : $66.0 million

                            November 08, 2022

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : GSK

                            Deal Size : $591.0 million

                            Deal Type : Licensing Agreement

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                            04

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : GSK

                            Deal Size : $816.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            GSK and Spero Therapeutics Announce Exclusive Licence Agreement for Tebipenem HBr, a Late-Stage Antibiotic tha...

                            Details : Under the licence agreement, Spero will be responsible for the execution and costs of the remaining phase III trial of tebipenem HBr. GSK will be responsible for the execution and costs of additional clinical development, including regulatory submission ...

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : $66.0 million

                            September 22, 2022

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : GSK

                            Deal Size : $816.0 million

                            Deal Type : Licensing Agreement

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                            05

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Therapeutics Provides Tebipenem HBr Program Update Following Type A Meeting with the U.S. Food and Drug ...

                            Details : FDA feedback indicates positive results from a single additional Phase 3 clinical trial in patients with complicated urinary tract infection (cUTI), with supportive confirmatory evidence of efficacy could support approval of SPR994 (tebipenem HBr).

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 06, 2022

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Therapeutics Submits New Drug Application to U.S. FDA for Tebipenem HBr for the Treatment of Complicated...

                            Details : Spero’s lead product candidate, tebipenem HBr (tebipenem pivoxil hydrobromide; formerly SPR994), is being developed as the first oral carbapenem antibiotic for use in cUTI, including pyelonephritis.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 28, 2021

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Spero Therapeutics

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                            Not Confirmed

                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : HealthCare Royalty Partners

                            Deal Size : $125.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Spero Therapeutics Enters Into a Non-Dilutive Revenue Interest Financing Agreement With HealthCare Royalty Par...

                            Details : Spero intends to use the proceeds from the agreement for launch of tebipenem HBr, for a complicated urinary tract infection (cUTI) indication as well as to support the continued clinical development of SPR720 and SPR206.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 30, 2021

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : HealthCare Royalty Partners

                            Deal Size : $125.0 million

                            Deal Type : Financing

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                            08

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Therapeutics to Present Data at IDWeek 2021

                            Details : Presentations will showcase in vitro and in vivo studies of tebipenem HBr for treatment of adults with complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) and highlight additional research on the epidemiology and management of cUTI.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 16, 2021

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Spero Therapeutics

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                            Not Confirmed

                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Therapeutics Announces Topline Results from its Phase 3 ADAPT-PO Trial of Tebipenem HBr in Complicated U...

                            Details : Pivotal Phase 3 clinical trial of oral tebipenem HBr met primary endpoint, demonstrating statistical non-inferiority versus intravenous ertapenem in patients with complicated urinary tract infection and acute pyelonephritis.

                            Brand Name : SPR994

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 08, 2020

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Spero Therapeutics

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                            Spero Therapeutics

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                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Spero Completes Patient Enrollment in Pivotal Phase 3 Clinical Trial of Oral Tebipenem HBr vs Intravenous Erta...

                            Details : Phase 3 clinical trial, ADAPT-PO, is evaluating tebipenem HBr for the treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP).

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 05, 2020

                            Lead Product(s) : Tebipenem Pivoxil Hydrobromide

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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