[{"orgOrder":0,"company":"TG Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Umbralisib","moa":"PI3-kinase p110-delta subunit","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"TG Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"TG Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"TG Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TG Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Umbralisib","moa":"PI3K delta\/CK1 epsilon","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"TG Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"TG Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"TG Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TG Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Umbralisib","moa":"PI3K delta","graph1":"Oncology","graph2":"Phase III","graph3":"TG Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"TG Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"TG Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TG Therapeutics","sponsor":"J.P. 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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Azercabtagene Zapreleucel (azer-cel) is an allogeneic CD19 CAR T cell therapy, which is being investigated for progressive forms of multiple sclerosis.

                          Brand Name : Azer-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 09, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Precision BioSciences

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Through agreement, Neuraxpharm will focus on the commercialization of Briumvi (ublituximab) in Europe, for the treatment of adults patients with relapsing forms of multiple sclerosis.

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : $152.5 million

                          February 26, 2024

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Neuraxpharm

                          Deal Size : $645.0 million

                          Deal Type : Agreement

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : TG Therapeutics received exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel (azer-cel), an allogeneic CD19 CAR T cell therapy for autoimmune diseases.

                          Brand Name : Azer-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $17.5 million

                          February 12, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Precision BioSciences

                          Deal Size : $305.5 million

                          Deal Type : Licensing Agreement

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : TG will receive exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel, an allogeneic CD19 CAR T cell therapy for autoimmune diseases and non-oncology indications.

                          Brand Name : Azer-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $7.5 million

                          January 09, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Precision BioSciences

                          Deal Size : $315.5 million

                          Deal Type : Licensing Agreement

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the agreement, TG Therapeutics will commercialise Briumvi (ublituximab), the first and only anti-CD20 monoclonal antibody approved in the United States and European Union for adult patients with relapsing forms of multiple sclerosis.

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : $140.0 million

                          August 01, 2023

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Neuraxpharm

                          Deal Size : $645.0 million

                          Deal Type : Licensing Agreement

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 01, 2023

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          March 31, 2023

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 14, 2023

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 26, 2023

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : BRIUMVI (ublituximab-xiiy), is the first and only anti-CD20 monoclonal antibody approved for patients with RMS that can be administered in a one-hour infusion following the starting dose.

                          Brand Name : Briumvi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          December 28, 2022

                          Lead Product(s) : Ublituximab-xiiy

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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