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                          01

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                          Details : The Company is initiating nonclinical studies to elucidate the mechanism for the observed transaminitis, which was not predicted by extensive GLP toxicology studies of THB001 nor observed in the Company’s Phase 1a study.

                          Brand Name : THB001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 15, 2022

                          Lead Product(s) : THB001

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

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                          Details : THB001, is a highly selective, oral small-molecule inhibitor of KIT, a cell surface receptor that serves as the master regulator of mast cell function and survival.

                          Brand Name : THB001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 14, 2022

                          Lead Product(s) : THB001

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $10.9 million

                          Deal Type : Public Offering

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                          03

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                          Details : This financing will fund development of the company’s lead candidate, THB001, through the next phase of human studies for the initial indication of chronic urticaria.

                          Brand Name : THB001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 16, 2022

                          Lead Product(s) : THB001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Atlas Venture

                          Deal Size : $105.0 million

                          Deal Type : Series B Financing

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