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Biotherapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"TILT Biotherapeutics \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"TILT Biotherapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TILT Biotherapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FINLAND","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"TILT-123","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"TILT Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"TILT Biotherapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"TILT Biotherapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TILT Biotherapeutics","sponsor":"Finland\u2019s Lifeline Ventures","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FINLAND","productType":"Large molecule","year":"2023","type":"Financing","leadProduct":"Avelumab","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"TILT Biotherapeutics","amount2":0.02,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"","sponsorNew":"TILT Biotherapeutics \/ Finland\u2019s Lifeline Ventures","highestDevelopmentStatusID":"6","companyTruncated":"TILT Biotherapeutics \/ Finland\u2019s Lifeline Ventures"},{"orgOrder":0,"company":"TILT Biotherapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FINLAND","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Avelumab","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"TILT Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by TILT Biotherapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The funding aims to support the clinical development of TILT-123 (igrelimogene litadenorepvec) in combination with pembrolizumab for treating platinum-resistant/refractory ovarian cancer patients.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          February 14, 2024

                          Lead Product(s) : Igrelimogene Litadenorepvec,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : U.S. Department of Defense

                          Deal Size : $2.0 million

                          Deal Type : Funding

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : TILT-123 (igrelimogene litadenorepvec) is a 5/3 chimeric serotype adenovirus armed with two human cytokines, which is being evaluated in combination with avelumab for squamous cell carcinoma of head and neck, and melanoma.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 15, 2023

                          Lead Product(s) : Igrelimogene Litadenorepvec,Avelumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The funding will be used to advance to Phase II the company’s combination trials of TILT-123 which use oncolytic immunotherapies synergistically with checkpoint inhibitors.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          February 07, 2023

                          Lead Product(s) : TILT-123,Avelumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Finland’s Lifeline Ventures

                          Deal Size : $23.8 million

                          Deal Type : Financing

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : TILT-123 is a human 5/3 chimeric adenovirus that has been engineered for targeting, safety and potency, is an oncolytic adenovirus coding for Tumor Necrosis Factor Alpha (TNF alpha) and Interleukin 2 (IL-2), designed to stimulate T cells to better fight ...

                          Brand Name : TILT-123

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 31, 2022

                          Lead Product(s) : TILT-123

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The trial’s objective is to evaluate the safety and efficacy of TILT-123 in combination with pembrolizumab and is designed to also deliver insights about the mechanism of action of TILT-123 in humans.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 14, 2021

                          Lead Product(s) : TILT-123,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : TILT Biotherapeutics has dosed its first patients and progressed to the second dose level in a monotherapy phase 1 clinical trial of TILT-123, a dual cytokine armed oncolytic adenovirus.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 05, 2021

                          Lead Product(s) : TILT-123

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The trial’s objective is to evaluate the safety and efficacy of TILT-123 in combination with pembrolizumab and is designed to also deliver insights about the mechanism of action of TILT-123 in humans.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 14, 2021

                          Lead Product(s) : TILT-123,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Recipient : Merck & Co

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Funds will be used to advance TILT's proprietary, best-in-class cytokine armed oncolytic adenovirus, TILT-123, into Phase 1 clinical trials in Europe and the United States, and to prepare for Phase 2 trials.

                          Brand Name : TILT-123

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 16, 2020

                          Lead Product(s) : TILT-123,Tumor infiltrating lymphocytes

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Lifeline Ventures

                          Deal Size : $6.9 million

                          Deal Type : Financing

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Under the agreement TILT has granted Biotheus rights for development and commercialization of TILT’s proprietary oncolytic virus TILT-123 in Greater China.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 27, 2020

                          Lead Product(s) : TILT-123

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Biotheus

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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