Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Igrelimogene Litadenorepvec,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : U.S. Department of Defense
Deal Size : $2.0 million
Deal Type : Funding
TILT Awarded $2 Million Grant from U.S. Department of Defense for Ovarian Cancer Research
Details : The funding aims to support the clinical development of TILT-123 (igrelimogene litadenorepvec) in combination with pembrolizumab for treating platinum-resistant/refractory ovarian cancer patients.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Undisclosed
February 14, 2024
Lead Product(s) : Igrelimogene Litadenorepvec,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : U.S. Department of Defense
Deal Size : $2.0 million
Deal Type : Funding
Details : TILT-123 (igrelimogene litadenorepvec) is a 5/3 chimeric serotype adenovirus armed with two human cytokines, which is being evaluated in combination with avelumab for squamous cell carcinoma of head and neck, and melanoma.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 15, 2023
Details : The funding will be used to advance to Phase II the company’s combination trials of TILT-123 which use oncolytic immunotherapies synergistically with checkpoint inhibitors.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Undisclosed
February 07, 2023
Details : TILT-123 is a human 5/3 chimeric adenovirus that has been engineered for targeting, safety and potency, is an oncolytic adenovirus coding for Tumor Necrosis Factor Alpha (TNF alpha) and Interleukin 2 (IL-2), designed to stimulate T cells to better fight ...
Brand Name : TILT-123
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 31, 2022
Lead Product(s) : TILT-123,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
TILT Biotherapeutics Submits IND for Phase I Trial of Immunotherapeutic TILT-123 in Ovarian Cancer
Details : The trial’s objective is to evaluate the safety and efficacy of TILT-123 in combination with pembrolizumab and is designed to also deliver insights about the mechanism of action of TILT-123 in humans.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 14, 2021
Lead Product(s) : TILT-123,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TILT Biotherapeutics has dosed its first patients and progressed to the second dose level in a monotherapy phase 1 clinical trial of TILT-123, a dual cytokine armed oncolytic adenovirus.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 05, 2021
Lead Product(s) : TILT-123,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Recipient : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The trial’s objective is to evaluate the safety and efficacy of TILT-123 in combination with pembrolizumab and is designed to also deliver insights about the mechanism of action of TILT-123 in humans.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Undisclosed
April 14, 2021
Lead Product(s) : TILT-123,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Recipient : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
TILT Biotherapeutics Secures Over EUR 6 million to Advance Cancer Immunotherapies Into Clinic
Details : Funds will be used to advance TILT's proprietary, best-in-class cytokine armed oncolytic adenovirus, TILT-123, into Phase 1 clinical trials in Europe and the United States, and to prepare for Phase 2 trials.
Brand Name : TILT-123
Molecule Type : Large molecule
Upfront Cash : Undisclosed
June 16, 2020
Details : Under the agreement TILT has granted Biotheus rights for development and commercialization of TILT’s proprietary oncolytic virus TILT-123 in Greater China.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 27, 2020
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