Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Declines to Approve Vanda's Marketing Application for Tradipitant in Gastroparesis
Details : VLY-686 (tradipitant) is an NK1R Inhibitor small molecule drug candidate, which is currently being evaluated for the treatment of gastroparesis via oral capsule.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 19, 2024
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Vanda Pharmaceuticals Reports Positive Phase III Result for Tradipitant in Motion Sickness
Details : VLY-686 (tradipitant) is a neurokinin-1 receptor antagonist licensed from Eli Lilly. Tradipitant is currently in clinical development for gastroparesis and motion sickness.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 15, 2024
Lead Product(s) : Tradipitant
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Eli Lilly
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VLY-686 (tradipitant) is an NK1R Inhibitor small molecule drug candidate, which is currently being evaluated for the treatment of gastroparesis via oral capsule.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 05, 2023
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vanda Pharmaceuticals Reports Results from a Phase III study of Tradipitant in Motion Sickness
Details : VLY-686 (tradipitant) is a neurokinin-1 receptor antagonist licensed by Vanda from Eli Lilly and Company. Tradipitant is currently in clinical development for gastroparesis and motion sickness.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 25, 2023
Lead Product(s) : Tradipitant
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vanda Pharmaceuticals Announces Presentations at DDW 2022
Details : Tradipitant (VLY-686 or LY686017) is an experimental drug that is a neurokinin 1 antagonist. It works by blocking substance P, a small signaling molecule.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 19, 2022
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vanda Pharmaceuticals Reports Results from the Phase III Study of Tradipitant in Gastroparesis
Details : Tradipitant is a neurokinin-1 receptor antagonist licensed by Vanda from Eli Lilly and Company. Tradipitant is currently in clinical development for gastroparesis and motion sickness.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 04, 2022
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The study was designed to determine whether tradipitant plus standard of care is superior to placebo plus standard of care in treating hospitalized patients with COVID-19 pneumonia who required supplemental oxygen support.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 03, 2021
Lead Product(s) : Tradipitant
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vanda Pharmaceuticals Provides Update on Tradipitant Development Program
Details : Article describes Vanda's Phase II double-blind trial of 152 adults with gastroparesis in the U.S. Patients receiving tradipitant had a significant decrease in nausea score at week 4 compared with placebo, and a significant increase in of nausea-free day...
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 31, 2020
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Interim analysis of the ODYSSEY study showed that a 14 day tradipitant treatment accelerated clinical improvement by day 7 (HR=2.55, p=0.0375).
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 18, 2020
Lead Product(s) : Tradipitant
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The patient and treating physician requested expanded access to continue treatment beyond 12 weeks, as the treating physician had judged that tradipitant was the only treatment that effectively managed the patient's gastroparesis symptoms.
Brand Name : VLY-686
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 13, 2020
Lead Product(s) : Tradipitant
Therapeutic Area : Gastroenterology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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