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Wainwright & Co.","pharmaFlowCategory":"D","amount":"$1.5 million","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics Announces Closing of $1.5 Million Registered Direct Offering of Common Stock Priced At-The-Market Under Nasdaq Rules","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"February 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Preclinical"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"BRAIN Biotech","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics and BRAIN Biotech Join Forces To Develop a CRISPR-derived Technology Platform For Cancer Treatment","therapeuticArea":"Oncology","highestDevelopmentStatus":"Discovery","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"February 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Discovery"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"TransCode Therapeutics Announces Orphan Drug Designation Status for TTX-MC138 for Treatment of Pancreatic Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"February 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Preclinical"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"National Institutes of Health","pharmaFlowCategory":"D","amount":"$0.8 million","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics Receives Notice of Award from National Institutes of Health (NIH) for Third Year of Grant to Support Clinical Evaluation of TTX-MC138","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Preclinical"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"White Lion Capital","pharmaFlowCategory":"D","amount":"$1.0 million","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics Announces Equity Investment from White Lion Capital to Help Fund Development of TTX-MC138 for Treatment of Glioblastomas","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Preclinical"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"TransCode Therapeutics Announces IRB Approval for FDA Cleared First-In-Human Clinical Trial","therapeuticArea":"Oncology","highestDevelopmentStatus":"IND Enabling","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2023","url1":"","url2":"","graph1":"Oncology","graph2":"IND Enabling"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"H.C. 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Wainwright & Co.","pharmaFlowCategory":"D","amount":"$7.25 million","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics Announces Closing of $7.25 Million Public Offering","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"H.C. Wainwright & Co.","pharmaFlowCategory":"D","amount":"$7.2 million","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics Announces Pricing of $7.25 Million Public Offering","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"TransCode Therapeutics Reports Positive Pre-Clinical Results in Metastatic Pancreatic Cancer with its Lead Candidate, TTX-MC138","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"December 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Preclinical"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"Debiopharm","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"TransCode Therapeutics and Debiopharm Announce Collaboration to Develop Targeted Nucleic Acid Therapeutics for Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"TransCode Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"TransCode Therapeutics Announces FDA Clearance To Initiate Phase 1\/2 Clinical Trial with TTX-MC138 in Patients with Advanced Solid Tumors","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"}]

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            TTX-MC138 is an antisense oligonucleotide that targets microRNA-10b, it consists of an iron oxide nanocarrier conjugated to a nucleic acid designed to inhibit microRNA-10b. It is being evaluated for advanced solid tumors.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I/ Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 15, 2024

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            The collaboration aims to support TransCode’s lead therapeutic candidate, TTX-MC138, which utilizes antisense technology in the treatment of metastatic cancer. Currently, it is undergoing assessment in an early-stage clinical trial.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Debiopharm

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration January 29, 2024

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            The net proceeds will be used for the clinical development of TTX-MC138 consisting of antagomirs against miRNA-10b conjugated to a unique delivery platform that focuses on the treatment of cancer.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

            Deal Size: $7.25 million Upfront Cash: Undisclosed

            Deal Type: Public Offering January 22, 2024

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            The net proceeds will be used for the clinical development of TTX-MC138 consisting of antagomirs against miRNA-10b conjugated to a unique delivery platform that focuses on the treatment of cancer.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

            Deal Size: $7.2 million Upfront Cash: Undisclosed

            Deal Type: Public Offering January 18, 2024

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            TTX-MC138 is an antisense oligonucleotide that targets microRNA-10b, it consists of an iron oxide nanocarrier conjugated to a nucleic acid designed to inhibit microRNA-10b. It is being evaluated for metastatic pancreatic cancer.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 12, 2023

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            Details:

            The company intends to use the net proceeds for one or more clinical trials with TTX-MC138, an antisense oligonucleotide targeting miR-10b and under investigation for the treatment of various metastatic cancers, including related investigational new drug enabling studies.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

            Deal Size: $1.2 million Upfront Cash: Undisclosed

            Deal Type: Public Offering December 04, 2023

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            The Company intends to use the net proceeds for one or more clinical trials with TTX-MC138, an antisense oligonucleotide that targets microRNA-10b, its lead therapeutic candidate, including related investigational new drug enabling studies.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: IND Enabling Product Type: Large molecule

            Partner/Sponsor/Collaborator: H.C. Wainwright & Co.

            Deal Size: $1.2 million Upfront Cash: Undisclosed

            Deal Type: Public Offering November 30, 2023

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            Details:

            The net proceeds of from this offering will be used for product development activities, including one or more clinical trials with TTX-MC138, including related IND-enabling studies, and for working capital and other general corporate purposes.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: ThinkEquity

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering October 26, 2023

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            Details:

            TTX-MC138 consists of an iron oxide nanocarrier conjugated to a nucleic acid designed to inhibit the oncogenic RNA, microRNA-10b. MiRNA-10b is described as the master regulator of cancer progression in a number of advanced solid tumors.

            Lead Product(s): TTX-MC138

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 26, 2023

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            Details:

            TTX-MC138 consists of an iron oxide nanocarrier conjugated to a nucleic acid specifically designed to inhibit the oncogenic RNA, microRNA-10b. MiRNA-10b has been described as the master regulator of cancer progression in a number of advanced solid tumors.

            Lead Product(s): TTX-MC138-NODAGA-Cu64

            Therapeutic Area: Oncology Product Name: TTX-MC138

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 24, 2023

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