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Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Puma Biotechnology \/ Not Applicable"},{"orgOrder":0,"company":"Viatris","sponsor":"Biocon","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Acquisition","leadProduct":"Trastuzumab","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Viatris","amount2":3.3399999999999999,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":3.3399999999999999,"dosageForm":"Injectable\/Injection","sponsorNew":"Viatris \/ Biocon","highestDevelopmentStatusID":"12","companyTruncated":"Viatris \/ Biocon"},{"orgOrder":0,"company":"Seagen","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"BridgeBio Oncology Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"BridgeBio Oncology Therapeutics \/ Not Applicable"}]

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                          01

                          Antibody Engineering
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                          Antibody Engineering
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                          Details : BBO-10203 is a first-in-class orally bioavailable RAS:PI3Ka breaker that blocks the interaction between RAS and PI3Kα to inhibit PI3Kα-AKT signaling in tumors.

                          Brand Name : BBO-10203

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 30, 2024

                          Lead Product(s) : BBO-10203,Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
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                          Antibody Engineering
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                          Details : HLX11 (pertuzumab biosimilar) is the HER2 humanized monoclonal antibody, which is being investigated for the treatment of HER2-positive/ HR-negative locally advanced breast cancer.

                          Brand Name : HLX11

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 30, 2024

                          Lead Product(s) : Pertuzumab,Trastuzumab,Docetaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Hercessi (trastuzumab-biosimilar) is biosimilar to Herceptin, which is indicatedfor the treatment of HER2 overexpressing breast cancer & metastatic gastric or gastroesophageal junction adenocarcinoma.

                          Brand Name : Hercessi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 18, 2024

                          Lead Product(s) : Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 31, 2024

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Tuznue (trastuzumab-biosimilar) is a HER2/neu receptor antagonist, which is indicatedfor the treatment of HER2 overexpressing breast cancer & metastatic gastric adenocarcinoma.

                          Brand Name : Tuznue

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 31, 2024

                          Lead Product(s) : Trastuzumab,Docetaxel,Epirubicin Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Mamitra, biosimilar of trastuzumab, is an anti-HER2 antibody-drug conjugate (ADC) which is being developed for HER2-positive unresectable locally advanced or metastatic breast cancer (MBC).

                          Brand Name : Mamitra

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 31, 2024

                          Lead Product(s) : Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The proceeds from the financing will be used to advance the IAM1363, a highly selective, brain-penetrant small molecule inhibitor, being evaluated for the treatment of HER2-mutated neoplasms.

                          Brand Name : IAM1363

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 18, 2024

                          Lead Product(s) : IAM1363,Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Mubadala Capital

                          Deal Size : $150.0 million

                          Deal Type : Series B Financing

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Keytruda (pembrolizumab) is a USFDA approved anti PD-L1 monoclonal antibody. It is being evaluated in combination with trastuzumab for HER2-positive advanced gastroesophageal junction adenocarcinoma.

                          Brand Name : Keytruda

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 01, 2024

                          Lead Product(s) : Pembrolizumab,Trastuzumab,Cisplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Hercessi (trastuzumab-biosimilar) is a HER2/neu receptor antagonist, which is indicated for HER2 overexpressing breast cancer & metastatic gastric or gastroesophageal junction adenocarcinoma.

                          Brand Name : Hercessi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 29, 2024

                          Lead Product(s) : Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The partnership seeks to enhance the commercialization efforts of Ogivri (trastuzumab), an FDA-approved biosimilar utilized in patients diagnosed with breast cancer or metastatic stomach cancer.

                          Brand Name : Ogivri

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          February 10, 2024

                          Lead Product(s) : Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Sandoz B2B

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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