Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Study Phase : Preclinical
Sponsor : Small Business Innovation Research
Deal Size : $2.0 million
Deal Type : Funding
Trethera Wins $2M NIH Grant for Pediatric Neurologic Disease Development
Details : The funding aims to support Trethera’s clinical stage and first-in-class drug, TRE-515 dCK inhibitor, which is being evaluated for the treatment of acute disseminated encephalomyelitis.
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 16, 2024
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Sponsor : Small Business Innovation Research
Deal Size : $2.0 million
Deal Type : Funding
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Study Phase : Preclinical
Sponsor : National Institute of Allergy and Infectious Diseases
Deal Size : $0.6 million
Deal Type : Funding
Details : The proceeds will be used for the preclinical development of Trethera’s first-in-class small molecule, TRE-515, an orally delivered, therapeutic engineered to inhibit dCK, for the treatment of acute disseminated encephalomyelitis, which holds the FDA O...
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 14, 2023
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Sponsor : National Institute of Allergy and Infectious Diseases
Deal Size : $0.6 million
Deal Type : Funding
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : National Institute of Allergy and Infectious Diseases
Deal Size : $0.6 million
Deal Type : Funding
Details : The grant will fund Investigational New Drug (IND) enabling activities using TRE-515, a first-in-class deoxycytidine kinase (dCK) inhibitor, to treat systemic lupus erythematosus (SLE), a chronic autoimmune disease with significant morbidity and mortalit...
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 27, 2023
Lead Product(s) : TRE-515
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : National Institute of Allergy and Infectious Diseases
Deal Size : $0.6 million
Deal Type : Funding
Lead Product(s) : TRE-515
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : National Cancer Institute
Deal Size : $2 million
Deal Type : Funding
Details : The grant will fund additional patient dosing studies to identify predictive biomarkers of activity and target engagement of TRE-515, a first-in-class deoxycytidine kinase inhibitor, in solid tumors.
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 30, 2023
Lead Product(s) : TRE-515
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : National Cancer Institute
Deal Size : $2 million
Deal Type : Funding
Details : TRE-515 is a potent and orally-bioavailable inhibitor of dCK that may have monotherapy activity against solid tumors where low expression of the de novo pathway or other metabolic changes occur creating greater sensitivity to nucleotide salvage pathway i...
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 15, 2023
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TRE-515 is an orally delivered first-in-class dCK inhibitor, the key enzyme in the nucleoside salvage pathway. TRE-515 is twice designated an Orphan Drug by the FDA in both optic neuritis and ADEM and is currently being studied in a Phase 1 oncology tria...
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 24, 2023
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : TRE-515
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : National Eye Institute
Deal Size : $1.6 million
Deal Type : Funding
Details : TRE-515 is a novel first-in-class drug, which has been shown to prevent demyelination, and even facilitate remyelination, in multiple demyelinating disease mouse models. Furthermore, the FDA has designated TRE-515 an Orphan Drug in the treatment of ON.
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 19, 2022
Lead Product(s) : TRE-515
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : National Eye Institute
Deal Size : $1.6 million
Deal Type : Funding
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TRE-515 is an orally delivered first-in-class therapeutic selectively inhibit symptoms in experimental autoimmune encephalomyelitis (EAE) mouse models of multiple sclerosis (MS).
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 04, 2022
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TRE-515 is a first-in-class drug targeting the enzyme deoxycytidine kinase (dCK) and currently in Phase 1 clinical trials. Trethera is currently enrolling a Phase 1 dose escalation trial to evaluate TRE-515 monotherapy in patients with various solid tumo...
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 20, 2022
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : UCLA
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TRE-515 is a first-in-class clinical stage drug that inhibits deoxycytidine kinase (dCK), the rate-limiting enzyme in the nucleoside salvage pathway, one of two biosynthetic pathways that generate DNA precursors.
Brand Name : TRE-515
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 07, 2022
Lead Product(s) : TRE-515
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : UCLA
Deal Size : Not Applicable
Deal Type : Not Applicable
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