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Bioscience","highestDevelopmentStatusID":"6","companyTruncated":"Trethera \/ Mabwell Bioscience"},{"orgOrder":0,"company":"Trethera","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"TRE-515","moa":"dCK","graph1":"Immunology","graph2":"Preclinical","graph3":"Trethera","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Trethera \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Trethera \/ Not Applicable"},{"orgOrder":0,"company":"Trethera","sponsor":"UCLA","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"TRE-515","moa":"dCK","graph1":"Neurology","graph2":"Phase I","graph3":"Trethera","amount2":0,"highestDevelopmentShortName":"Ph 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                          01

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The funding aims to support Trethera’s clinical stage and first-in-class drug, TRE-515 dCK inhibitor, which is being evaluated for the treatment of acute disseminated encephalomyelitis.

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 16, 2024

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : Small Business Innovation Research

                          Deal Size : $2.0 million

                          Deal Type : Funding

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                          02

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The proceeds will be used for the preclinical development of Trethera’s first-in-class small molecule, TRE-515, an orally delivered, therapeutic engineered to inhibit dCK, for the treatment of acute disseminated encephalomyelitis, which holds the FDA O...

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 14, 2023

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : National Institute of Allergy and Infectious Diseases

                          Deal Size : $0.6 million

                          Deal Type : Funding

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                          03

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The grant will fund Investigational New Drug (IND) enabling activities using TRE-515, a first-in-class deoxycytidine kinase (dCK) inhibitor, to treat systemic lupus erythematosus (SLE), a chronic autoimmune disease with significant morbidity and mortalit...

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 27, 2023

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : National Institute of Allergy and Infectious Diseases

                          Deal Size : $0.6 million

                          Deal Type : Funding

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                          04

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The grant will fund additional patient dosing studies to identify predictive biomarkers of activity and target engagement of TRE-515, a first-in-class deoxycytidine kinase inhibitor, in solid tumors.

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 30, 2023

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : National Cancer Institute

                          Deal Size : $2 million

                          Deal Type : Funding

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                          05

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is a potent and orally-bioavailable inhibitor of dCK that may have monotherapy activity against solid tumors where low expression of the de novo pathway or other metabolic changes occur creating greater sensitivity to nucleotide salvage pathway i...

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 15, 2023

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is an orally delivered first-in-class dCK inhibitor, the key enzyme in the nucleoside salvage pathway. TRE-515 is twice designated an Orphan Drug by the FDA in both optic neuritis and ADEM and is currently being studied in a Phase 1 oncology tria...

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 24, 2023

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is a novel first-in-class drug, which has been shown to prevent demyelination, and even facilitate remyelination, in multiple demyelinating disease mouse models. Furthermore, the FDA has designated TRE-515 an Orphan Drug in the treatment of ON.

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 19, 2022

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : National Eye Institute

                          Deal Size : $1.6 million

                          Deal Type : Funding

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                          08

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is an orally delivered first-in-class therapeutic selectively inhibit symptoms in experimental autoimmune encephalomyelitis (EAE) mouse models of multiple sclerosis (MS).

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 04, 2022

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is a first-in-class drug targeting the enzyme deoxycytidine kinase (dCK) and currently in Phase 1 clinical trials. Trethera is currently enrolling a Phase 1 dose escalation trial to evaluate TRE-515 monotherapy in patients with various solid tumo...

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 20, 2022

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TRE-515 is a first-in-class clinical stage drug that inhibits deoxycytidine kinase (dCK), the rate-limiting enzyme in the nucleoside salvage pathway, one of two biosynthetic pathways that generate DNA precursors.

                          Brand Name : TRE-515

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 07, 2022

                          Lead Product(s) : TRE-515

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : UCLA

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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